A5100641576- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Advanced Cellulose Research Studies
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Digital Marketing and Social Media
- Surface Modification and Superhydrophobicity
- Immune cells in cancer
- Social Capital and Networks
- Genomics, phytochemicals, and oxidative stress
- Pharmaceutical studies and practices
- Climate change impacts on agriculture
- Adenosine and Purinergic Signaling
- Protease and Inhibitor Mechanisms
- Connexins and lens biology
- Dermatologic Treatments and Research
- Hydrology and Drought Analysis
- Innovation and Socioeconomic Development
- Antimicrobial Peptides and Activities
- 14-3-3 protein interactions
- Marine Bivalve and Aquaculture Studies
- Plant Pathogenic Bacteria Studies
Capital Medical University
2022-2024
Soochow University
2024
Shandong Transportation Research Institute
2024
Shandong University
2024
Hubei Provincial Hospital of Traditional Chinese Medicine
2024
Insilico Medicine (United States)
2024
Insilicos (United States)
2024
University of Arizona
2021-2024
Shenzhen Institutes of Advanced Technology
2024
Beijing Friendship Hospital
2023-2024
Drought evolution is a complex dynamic process, showing continuous characteristics in space-time. Currently, the researches on drought dynamics from multiple dimensions are limited and should be improved further. Therefore, three-dimensional identification method was adopted to investigate spatiotemporal patterns of classified events (namely two-month events, within-year cross-year events) northwest China during1961–2018. Furthermore, more spatial variables event, such as start end location,...
Hypoxia-inducible factor prolyl hydroxylase (PHD) inhibitors have been approved for treating renal anemia yet failed clinical testing inflammatory bowel disease because of a lack efficacy. Here we used multimodel multimodal generative artificial intelligence platform to design an orally gut-restricted selective PHD1 and PHD2 inhibitor that exhibits favorable safety pharmacokinetic profiles in preclinical studies. ISM012-042 restores intestinal barrier function alleviates gut inflammation...
Implant therapy is a well-established clinical treatment, and porous implants are reported to be advantageous, which needs confirmed in vivo. In this study, we designed fabricated titanium with the same shape but different porosities (20 %, 30 40 50 respectively), produce elastic moduli based on results of finite element analysis (FEA). These devices were implanted into mandibular alveolar bone miniature swine, their survival rates, osseointegration, marginal loss evaluated one, three, six...
This article delves into the role of social media in field marketing and its development trends. By analyzing definition, development, characteristics media, it highlights profound impact on activities. The examines three key factors: users, content, trends, offers targeted recommendations, such as precise user interaction, optimized content production, adapting to emerging Finally, emphasizes that businesses should remain flexible innovative adapt rapidly changing environment, order achieve...
Identification of all phosphorylation forms known proteins is a major goal the Chromosome-Centric Human Proteome Project (C-HPP). Recent studies have found that certain phosphoproteins can be encapsulated in exosomes and function as key regulators tumor microenvironment, but no deep coverage phosphoproteome human has been reported to date, which makes exosome potential source for new phosphosite discovery. In this study, we performed highly optimized MS analyses on exosomal cellular isolated...
It is well established that Nrf2 plays a crucial role in anti-oxidant and anti-inflammatory functions. However, its antiviral capabilities remain less explored. Despite this, several activators have demonstrated anti-SARS-CoV-2 properties, though the mechanisms behind these effects are not fully understood. In this study, using two mouse models of SARS-CoV-2 infection, we observed absence significantly increased viral load altered inflammatory responses. Additionally, evaluated five...
Preeclampsia (PE) is a placenta disease, featured by hypertension, proteinuria, and other multiorgan dysfunctions, its etiology unclear. We others have shown that intensive endoplasmic reticulum (ER) stress unfolded protein response (UPR) occur in the PE placenta. In this study, we isolated detergent-insoluble proteins (DIPs) from human tissues, which were enriched with aggregates, to characterize UPR PE. With data-independent acquisition (DIA) mass spectrometry, identified 2066 DIPs across...
We used mechanism-informed phenotypic screening to identify and optimize compounds that phenocopy the genetic depletion of mitotic aurora kinase B (AURKB) kinase. After assaying nine aryl fused seven-membered lactam compounds, we identified a hit compound 6a was subsequently optimized five lead with low nanomolar activity, represented by 6v (19 nM). With excellent drug-like properties, these reproduced loss function in phenotypes AURKB exhibited potent cytotoxic activities various cancer...
Dendritic cells (DCs) can mediate inflammation-related bone resorption that is crucial in the development of periodontitis. Butyrate a critical by-product microbes with antibacterial and anti-inflammatory properties. Here, we found butyrate inhibited activation lipopolysaccharide (LPS)-induced DCs generation inflammatory cytokines by DCs. Moreover, regulated glycolysis LPS-induced via G-protein-coupled receptor/hypoxia-inducible factor-1α pathway. In addition, maturation CD11c+MHC-II+ vivo,...
Purpose This study aims to explore the social networks and network interactions of bed-and-breakfast (B&B) entrepreneurs in rural China. In addition, it evaluates how such relate resilience. Design/methodology/approach In-depth interviews were performed two locations: Ningbo Dujiangyan, Purposive sampling was combined with snowball select interviewees. The 154 involved 29 B&B owners relevant actors. All codes data analyzed using discourse analysis framework. Findings owners’...
Abstract Synovitis is a key contributor to the inflammatory environment in osteoarthritis (OA) joints. Currently, biological therapy of OA not satisfactory multiple single-target trials on anti-TNF agents, or IL-1 antagonists. Systems understanding phosphorylation state synovium warranted direct further therapeutic strategies. Therefore, this study, we compared human synovial phosphoproteome with acute joint fracture subjects. We found that had significantly more phosphoproteins, and 82...
T-cell dysfunction has been shown to play an important role in the pathogenesis of Sjögren’s syndrome (SS). In recent studies, increased expression BMP6 reported be related SS. However, roles that plays immune homeostasis development SS as well downstream signals activated by remain unclear. this study, we investigated effects and molecular mechanisms on naive CD4 + T cells, showing could upregulate interferon (IFN)–γ secretion from cells through a ceramide/nuclear factor–κB pathway, with no...
Keloid is a benign tumor characterized by persistent inflammation, increased fibroblast proliferation, and abnormal deposition of collagen in the wound. The etiology keloid unclear. Here, we explored phospho-signaling changes human fibroblasts via phosphoproteome mass spectrometry analysis. We found that comparative phosphoproteomics could statistically distinguish from control fibroblasts. Differentially expressed phosphoproteins predict activation known keloid-relevant upstream regulators...
Abstract Increased fructose consumption has been elucidated to contribute metabolic diseases. Bone is a dynamic organ that undergoes constant remodeling. However, the effects of on bone health are still in dispute. Here, we identified deteriorated mineral density while promoting abundance marrow adipose tissue. Fructose remarkably promoted mesenchymal stem cells’ (BMMSCs) adipogenic commitment at expense osteogenic commitment. boosted glycolysis BMMSCs and inhibited phosphorylation adenosine...
The rapid evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly due to its high mutation rate and viral replication, has led new variants resistant the available vaccines monoclonal antibodies. In contrast, oral clinical drugs targeting protease RNA polymerase remain effective against Omicron [1]. Main (Mpro) plays a crucial role in maturation replication strains, making it an attractive target for developing antiviral drugs. Nirmatrelvir (NTV) is first-in-class...
<title>Abstract</title> Pervious concrete (PC), commonly used in urban pavement is known for its high permeability, which contributes to mitigating the heat island. However, low strength and durability of PC limit use. The objective this study improve mechanical properties by adding cellulose nanofibrils (CNFs). results showed that CNFs significantly enhanced compressive strength, flexural salt frost resistance, with optimal performance at 0.15% CNF. At concentration, strengths increased...
<title>Abstract</title> Metabolic pathways are crucial for regulating immune responses, yet the specific mechanisms influencing innate immunity in fish during viral infections remain poorly understood. This study aims to bridge this gap by elucidating role of hexosamine biosynthesis pathway (HBP)–associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling enhancing antiviral zebrafish. We discovered that infection with spring viremia carp virus (SVCV) significantly activates HBP, leading...
Pinctada fucata, the pearl oyster, is a bivalve primarily cultivated for production of saltwater pearls. In this study, genome-wide association study (GWAS) growth-related traits and principal components analysis (PCA) in P. fucata were performed. Genomic parameters 6 60 individuals estimated by using 4,937,162 single-nucleotide polymorphisms (SNPs). A total 45 SNPs associated with growth thus identified. Furthermore, 165 candidate genes identified, including collagen alpha-3 (VI),...
To determine the effect of serine/threonine protein kinase (STPK) gene on leaf lettuce bolting, we utilized virus-induced silencing (VIGS) using TRV vector to silence target gene. The 'GB30ʹ cultivar was test material, and methods included cloning, bioinformatics analysis, quantitative real-time PCR (qRT-PCR) VIGS. LsSTPK, cloned from via reverse transcription-polymerase chain reaction (RT-PCR). qRT-PCR analysis showed that expression LsSTPK in stem significantly greater than roots leaves,...