A5100353065- Smart Agriculture and AI
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds in Plants
- Innovation and Knowledge Management
- Tea Polyphenols and Effects
- Gut microbiota and health
- Remote Sensing in Agriculture
- Remote Sensing and LiDAR Applications
- Spectroscopy and Chemometric Analyses
- Proteins in Food Systems
- Polysaccharides and Plant Cell Walls
- International Business and FDI
- Advanced Algorithms and Applications
- Biochemical Analysis and Sensing Techniques
- Pharmacological Effects of Natural Compounds
- Advanced Measurement and Detection Methods
- Leaf Properties and Growth Measurement
- Remote Sensing and Land Use
- Obesity, Physical Activity, Diet
- Polysaccharides Composition and Applications
- Reproductive Biology and Fertility
- Cancer Mechanisms and Therapy
- Bioactive natural compounds
- Meat and Animal Product Quality
- Microbial Metabolites in Food Biotechnology
Nankai University
2019-2025
Xinjiang Agricultural University
2024-2025
Kunming Institute of Botany
2022-2025
Chinese Academy of Sciences
2022-2025
Anhui Agricultural University
2023-2025
China Agricultural University
2014-2024
Rutgers, The State University of New Jersey
2017-2024
Hebei University
2024
Ministry of Agriculture and Rural Affairs
2023-2024
Guangdong Academy of Agricultural Sciences
2022-2024
Abstract Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. We identify TRAF2- and NCK-interacting kinase (TNIK) as anti-fibrotic target using predictive artificial intelligence (AI) approach. Using AI-driven methodology, we generated INS018_055, small-molecule TNIK inhibitor, which exhibits desirable drug-like properties activity...
Summary Caseinolytic peptidase P mediates degradation of unfolded mitochondrial proteins and activates protein response (mt UPR ) to maintain homeostasis. Clpp −/− female mice generate a lower number mature oocytes two‐cell embryos, no blastocysts. have smaller mitochondria, with aspect ratio (length/width), decreased expression genes that promote fusion. A 4‐fold increase in atretic follicles at 3 months, reduced primordial 6–12 months are observed ovaries. This is associated upregulation...
Aged citrus peels (<italic>chenpi</italic>) have been used as a dietary supplement for gastrointestinal health maintenance in China.
Cyclin-dependent kinases 12 and 13 (CDK12/13) safeguard genomic integrity by preferentially regulating gene expression in the DNA damage response (DDR). The CDK12/13-mediated upregulation of DDR genes pathways significantly contributes to both tumorigenesis development resistance antitumor therapies. Thus, functional inhibition CDK12/13 offers an attractive strategy combat carcinogenesis, particularly for refractory treatment-resistant cancers. Here, we report discovery compound 12b as a...
Abstract Past research focusing on large firms has argued that information technology (IT) capability enhances firm performance. However, these studies have seldom explored why develop IT capability, and also left a void the understanding of role in Small‐ medium‐sized enterprises (SMEs). This study attempts to fill by examining effect relevant environmental firm‐level factors export performance Chinese US born‐global firms, special breed export‐focused SMEs. Results indicate such as...
The increasing economic importance and the number of born global firms make it worthwhile to study what leads their success in international market. To better understand this business phenomenon, we conducted in‐depth interviews with managers, coupled public database Web site searches. Research propositions were developed based on an extensive qualitative method. relationship between organizational culture, information technology capability, performance is proposed context firms, viewing...
The therapeutic effect of corilagin (1) was evaluated in an acute colitis model induced by dextran sulfate sodium (DSS) mice, and the mechanism action investigated this study. Animals were challenged with 2% DSS drinking water for 5 consecutive days then intraperitoneally treated 1 (7.5, 15, 30 mg/kg) daily 7 days. It found that significantly decreased disease activity index, inhibited shortening colon length, reduced tissue damage, suppressed myeloperoxidase activity. Moreover, greatly...
Scope (−)‐Epigallocatechin 3‐ O ‐(3‐ ‐methyl) gallate (EGCG3″Me) has been shown to have a modulatory effect on human intestinal microbiota, and the relationship between flora obesity attracted more attention recently. Here, potential link EGCG3″Me gut microbiota composition, as well underlying mechanisms of anti‐obesity activity are investigated. Methods results was prepared from oolong tea by column chromatography, influence analyzed using human‐flora‐associated high fat diet (HFD)‐induced...
The bidirectional interaction of gut microbiota and nobiletin is an important pathway for its anti-obesity activity.
Hypoxia-inducible factor prolyl hydroxylase (PHD) inhibitors have been approved for treating renal anemia yet failed clinical testing inflammatory bowel disease because of a lack efficacy. Here we used multimodel multimodal generative artificial intelligence platform to design an orally gut-restricted selective PHD1 and PHD2 inhibitor that exhibits favorable safety pharmacokinetic profiles in preclinical studies. ISM012-042 restores intestinal barrier function alleviates gut inflammation...
Background: Water consumption as a vital component of the human diet is under-researched in dietary surveys and nutrition studies. Aim: To assess total water fluid intakes examine demographic, anthropometric, factors associated with Australian population. Methods: Dietary intake data from 2011 to 2012 National Nutrition Physical Activity Survey were used. Usual water, food nutrient estimated two days recalls. Total includes plain drinking moisture all beverage sources; fluids include other...
Esophageal cancer, a leading cause of cancer death worldwide, is associated with abnormal activation the AKT signaling pathway. Xanthohumol, prenylated flavonoid tested in clinical trials, reported to exert anti-diabetes, anti-inflammation and anticancer activities. However, mechanisms underlying its chemopreventive or chemotherapeutic effects remain elusive. In present study, we found that xanthohumol directly targeted AKT1/2 esophageal squamous cell carcinoma (ESCC). Xanthohumol...