A5100386521- Natural Antidiabetic Agents Studies
- Chemical synthesis and alkaloids
- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Ethnobotanical and Medicinal Plants Studies
- Viral gastroenteritis research and epidemiology
- RNA Research and Splicing
- Microtubule and mitosis dynamics
- Bioactive Compounds and Antitumor Agents
- Cancer-related Molecular Pathways
- Migraine and Headache Studies
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Alkaloids: synthesis and pharmacology
- Traditional and Medicinal Uses of Annonaceae
- Genomics, phytochemicals, and oxidative stress
- Influenza Virus Research Studies
- Hemodynamic Monitoring and Therapy
- Tracheal and airway disorders
- Ubiquitin and proteasome pathways
Pukyong National University
2024
Zhengzhou University
2017-2024
Bayer (Germany)
2013-2024
Weatherford College
2024
Jinan Central Hospital
2024
Shandong First Medical University
2024
Xuzhou No.1 People's Hospital
2024
Xuzhou Medical College
2024
China-US (Henan) Hormel Cancer Institute
2017-2023
Institute of Hydrobiology
2023
Abstract Overexpression or activation of AKT is very well known to control cell growth, survival, and gene expression in solid tumors. Oridonin, an inflammatory medical diterpenoid compound isolated from Rabdosia rubescens, has exhibited various pharmacologic physiologic properties, including antitumor, antibacterial, anti-inflammatory effects. In this study, we demonstrated that oridonin inhibitor suppresses proliferation esophageal squamous carcinoma (ESCC) vitro vivo. The role ESCC was...
Esophageal cancer, a leading cause of cancer death worldwide, is associated with abnormal activation the AKT signaling pathway. Xanthohumol, prenylated flavonoid tested in clinical trials, reported to exert anti-diabetes, anti-inflammation and anticancer activities. However, mechanisms underlying its chemopreventive or chemotherapeutic effects remain elusive. In present study, we found that xanthohumol directly targeted AKT1/2 esophageal squamous cell carcinoma (ESCC). Xanthohumol...
Esophageal squamous cell carcinoma (ESCC) is an aggressive and lethal cancer with a low 5 year survival rate. Identification of new therapeutic targets its inhibitors remain essential for ESCC prevention treatment.TYK2 protein levels were checked by immunohistochemistry. The function TYK2 in proliferation was investigated MTT [(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] anchorage-independent growth. Computer docking, pull-down assay, surface plasmon resonance, kinase assay...
Abstract Osteosarcoma is the primary human malignant tumor affecting bone. This cancer most frequently arises in children and adolescents, with a second peak those over age of 50. Currently, surgery followed by radiotherapy chemotherapy are main treatments, but long‐term positive effects very poor. Aurora B kinase serine/threonine that key regulator cell cycle mitosis. Tissue array analysis revealed overexpressed osteosarcoma compared normal bone tissue. We developed compound, HOI‐07 (i.e.,...
Abstract Rationale A high risk of post‐operative recurrence contributes to the poor prognosis and low survival rate oesophageal squamous cell carcinoma (ESCC) patients. Increasing experimental evidence suggests that integrin adhesion receptors, in particular αv (ITGAV), are important for cancer survival, proliferation migration. Therefore, targeting ITGAV may be a rational approach preventing ESCC recurrence. Materials methods Protein levels were determined human tumour tissues using...
Stereumins H (1), I (2), and J (3), three sesquiterpenes possessing a novel stereumane-type backbone, were isolated from an extract of culture broth the Basidiomycete Stereum sp. CCTCC AF 207024. The complete structural assignments including absolute configurations are reported by using X-ray studies density functional theory at B3LYP/aug-cc-pVDZ//B3LYP/6-31G(d) level.
Abstract Purpurogallin is a natural compound that extracted from nutgalls and oak bark it possesses antioxidant, anticancer, anti‐inflammatory properties. However, the anticancer capacity of purpurogallin its molecular target have not been investigated in esophageal squamous cell carcinoma (ESCC). Herein, we report suppresses ESCC growth by directly targeting mitogen‐activated protein kinase 1/2 (MEK1/2) signaling pathway. We found inhibits anchorage‐dependent ‐independent growth. The...
Primary headache is a disorder with high incidence and low diagnostic accuracy; the of migraine tension-type ranks first among primary headaches. Artificial intelligence (AI) decision support systems have shown great potential in medical field. Therefore, we attempt to use machine learning build clinical decision-making system for headaches.The demographic data characteristics 173 patients were collected by questionnaires. Decision tree, random forest, gradient boosting algorithm vector...
To investigate the possible roles of E-selectin and its ligand, Sialyl Lewis X, in lymph node metastasis invasive micropapillary carcinoma breast, 100 cases 97 ductal were analyzed immunohistochemically for expression along with CD34, to measure microvessel density carcinoma. We found that number E-selectin—positive vessels was greater than carcinoma, it significantly correlated histological grade, positive nodes, The X higher which also associated metastasis. In predominantly stroma-facing...
Rapid detection of avian influenza virus (AIV) infection is critical for control (AI) and reducing the risk pandemic human influenza. A double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) was developed this purpose. The method employed a monoclonal (MAb) as capture rabbit polyclonal IgG labeled with horseradish peroxidase detector antibody, both antibodies were against type-specific nucleoprotein (NP). DAS-ELISA could detect minimally 2.5 ng viral protein in preparations...
Abstract To explore the function of ornithine decarboxylase in esophageal squamous cell carcinoma progression and test effectiveness anti-ornithine therapy for carcinoma. In this study, we examined expression pattern lines tissues using immunohistochemistry Western blot analysis. Then investigated ESCC cells by shRNA an irreversible inhibitor decarboxylase, difluoromethylornithine. gather more supporting pre-clinical data, a human patient-derived xenograft mouse model (C.B-17 severe combined...
Esophageal Squamous Cell Carcinoma (ESCC) is the predominant type of Cancer (EC), accounting for nearly 88% EC incidents worldwide.Importantly, it also a life-threatening cancer patients diagnosed in advanced stages, with only 20% 5-year survival rate due to limited number actionable targets and therapeutic options.Increasing evidence has shown that inter-tumor intra-tumor heterogeneity are widely distributed across ESCC tumor tissues.In our work, multi-omics data from cell lines, tissue,...
Abstract Two new sesquiterpenes, stereumin F ( 1 ) and G 2 ), together with two known compounds (3 β ,5 α ,22 E ,24 R )‐5,8‐epidioxyergosta‐6,22‐dien‐3‐ol 3 4‐(2‐hydroxyethyl)phenol 4 were isolated from the AcOEt extract of culture broth MeOH mycelium fungal strain Stereum sp. CCTCC AF 207024. Their structures established on basis spectral analyses.
Intake of soy isoflavones is inversely associated with the risk esophageal cancer. Numerous experimental results have supported anticancer activity isoflavones. This study aimed to determine anti-esophageal cancer 6,7,4'-trihydroxyisoflavone (6,7,4'-THIF), a major metabolite daidzein, which readily metabolized in human body. Notably, 6,7,4'-THIF inhibited proliferation and increased apoptosis cells. On basis virtual screening analysis, Pin1 was identified as target protein 6,7,4'-THIF....