A5019342088- Long-Term Effects of COVID-19
- Neurobiology of Language and Bilingualism
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
- Reading and Literacy Development
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Research and Treatments
- Respiratory Support and Mechanisms
- Inflammasome and immune disorders
- Liver physiology and pathology
- Educational Technology and Pedagogy
- Medical Imaging and Pathology Studies
- Esophageal Cancer Research and Treatment
- Drug Transport and Resistance Mechanisms
- Skin Protection and Aging
- TGF-β signaling in diseases
- Chromatin Remodeling and Cancer
- Berberine and alkaloids research
- Ginseng Biological Effects and Applications
- Multisensory perception and integration
- Lung Cancer Research Studies
- Text Readability and Simplification
- Occupational and environmental lung diseases
- RNA modifications and cancer
Hubei University
2024
Zhengzhou University
2018-2023
China-US (Henan) Hormel Cancer Institute
2019-2023
Henan Cancer Hospital
2020-2023
Northeast Normal University
2020-2021
First Affiliated Hospital of Guangzhou Medical University
2021
State Key Laboratory of Respiratory Disease
2021
Guangzhou Medical University
2021
University of South China
2019
University of Minnesota
2019
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with few treatment options. The poor success in developing anti-IPF strategies has impelled researchers to reconsider the importance of choice animal model and assessment methodologies. Currently, it still not settled whether bleomycin-induced mouse finally returns resolution. Methods This study aimed follow dynamic fibrotic features bleomycin-treated lungs over extended durations through combination latest technologies...
Although COVID-19 has become a major challenge to global health, there are currently no efficacious agents for effective treatment. Cytokine storm syndrome (CSS) can lead acute respiratory distress (ARDS), which contributes most mortalities. Research points interleukin 6 (IL-6) as crucial signature of the cytokine storm, and clinical use IL-6 inhibitor tocilizumab shows potential treatment patient. In this study, we challenged wild-type adenovirus-5/human angiotensin-converting enzyme...
Abstract Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal cell carcinoma (ESCC) including low-grade and high-grade intraepithelial neoplasia. Due to absence molecular indicators, which ESPL will eventually develop into ESCC thus should be treated is not well defined. Indicators, for predicting risks at stages, an urgent need. We perform spatial whole-transcriptome atlas analysis, can eliminate other tissue interference by sequencing specific regions. In this...
Our preclinical data showed that the leukotriene A4 hydrolase (LTA4H) pathway plays a role in colorectal cancer (CRC). High expression of LTA4H and B4 receptor type 1 (BLT1) were also associated with CRC survival probability. Clinical samples evaluated to determine whether could serve as therapeutic target (LTB4) be used biomarker for evaluating efficacy bestatin CRC.Patients Stage I-III did or not receive prior surgery. Evaluable pairwise patient blood collected evaluate LTB4 concentration....
The overall 5-year survival rate of lung cancer is about 15% even with therapeutic drugs like tyrosine kinase inhibitors. Ideal models are urgently needed for exploring mechanisms and finding new drugs. Patient-derived xenografts (PDX) primary cells both used to screen regimens cancer. However, PDX from the same patient difficult establish. Their consistency original tumor tissue not well studied. 31 tissues were procured establish cell lines. Tumor growth measurements, histological...
Abstract Ramulus Cinnamomi (RC)–Radix Glycyrrhizae (RG) is a classic herb pair, which commonly used as fixed form to treat cardiovascular disease in the clinic. Our work aimed compare pharmacokinetic difference of cinnamic acid, liquiritin, isoliquiritigenin and glycyrrhetinic acid rats after oral administration RC–RG pair extracts [Guizhigancao Decoction (GGD) Lingguizhugan (LGZGD)] single RC or RG extract. A HPLC‐MS method was developed validated study comparative pharmacokinetics. The...
Andrographolide (Andro), a diterpenoid extracted from Andrographis paniculata, has been shown to attenuate pulmonary fibrosis in rodents; however, the potential mechanisms remain largely unclear. This study investigated whether and how Andro alleviates bleomycin (BLM)-induced NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation epithelial-mesenchymal transition (EMT) lung epithelial cells.The vivo effects of were evaluated rat model BLM-induced fibrosis. The...
Abstract Social hierarchical information impacts language comprehension. Nevertheless, the specific process underlying integration of linguistic and extralinguistic sources social has not been identified. For example, Chinese verb 赡养, /shan4yang3/, ‘support: provide for needs comfort one’s elders’, only allows its Agent to have a lower status than Patient. Using eye-tracking, we examined precise time course these semantic selectional restrictions verbs during natural reading. A 2 (Verb Type:...
Abstract COVID-19 has become a major challenge to global health, and until now, no efficient antiviral agents have been developed. The SARS-CoV-2 infection is characterized by pulmonary systemic inflammation in severe patients, acute respiratory distress syndrome (ARDS) caused failure contributes most mortalities. There an urgent need for developing effective drugs vaccines against ARDS. However, researchers cannot perform related researches due lacking P3 or P4 facility. We developed...
Abstract LS‐177 is a novel small‐molecule kinase inhibitor employed to interrupt the c‐Met signaling pathway. A rapid and sensitive ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method was developed validated for determination of in rat plasma tissues. The biosamples were extracted by liquid–liquid extraction with methyl tert ‐butyl ether separated on C 18 column (50 × 4.6 mm, 2.6 µm) using gradient elution mobile phase consisting acetonitrile–0.1% formic acid...
Cancer is the leading cause of death all over world. Among chemotherapy drugs, taxanes play an important role in cancer treatment. 6258-70 a new semi-synthetic taxane which has broad spectrum antitumor activity. A fast and reliable high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed for quantification rat plasma tissues this paper. After extraction by liquid-liquid with methyl tert-butyl ether, samples were separated on Kinetex C18 column (50...
LS177 is a novel inhibitor of mesenchymal epithelial transition (MET) that was used as an anticancer agent. The present study to evaluate the absolute bioavailability in rats. A rapid and sensitive ultra‐high performance liquid chromatography‐mass spectrometry (UHPLC‐MS/MS) method has been developed validated for determination rat plasma. internal standard (IS, LS410) were extracted from plasma samples by protein precipitation (PPT) intravenous group liquid‐liquid extraction (LLE) procedure...
Object tracking is a difficult task in computer vision, which usually affected by color, surrounding illumination, variation of the object's appearance and other factors. In previous years, many algorithms can only set up fixed models to track object. Recently, more have been proposed deal with object illumination change. However, these are easily influenced background for short time. A novel incremental principal component algorithm classifier detection solve drifting long-term problems....