A5040491475- CAR-T cell therapy research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Neonatal Respiratory Health Research
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Whipple's Disease and Interleukins
- Cancer Cells and Metastasis
- Advancements in Semiconductor Devices and Circuit Design
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Research and Treatments
- T-cell and Retrovirus Studies
- Inhalation and Respiratory Drug Delivery
- PARP inhibition in cancer therapy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Structural Anomalies and Repair
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Extracellular vesicles in disease
State Key Laboratory of Respiratory Disease
2016-2025
Guangzhou Institutes of Biomedicine and Health
2015-2025
Chinese Academy of Sciences
2015-2025
First Affiliated Hospital of Guangzhou Medical University
2021-2023
Guangzhou Medical University
2021-2023
National Clinical Research
2022
Affiliated Hospital of Zunyi Medical College
2014
The lack of a general clinic-relevant model for human cancer is major impediment to the acceleration novel therapeutic approaches clinical use. We propose establish and characterize primary hepatocellular carcinoma (HCC) xenografts that can be used evaluate cytotoxicity adoptive chimeric antigen receptor (CAR) T cells accelerate translation CAR in HCC. Primary HCCs were xenografts. morphology, immunological markers, gene expression characteristics detected compared those corresponding...
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In recent years, immunotherapies, such as those involving chimeric antigen receptor (CAR) T cells, have become increasingly promising approaches to non-small-cell lung cancer (NSCLC) treatment. this study, we explored the antitumor potential of prostate stem cell (PSCA)-redirected CAR and mucin 1 (MUC1)-redirected cells in tumor models NSCLC. First, generated patient-derived xenograft (PDX) mouse human NSCLC that maintained antigenic profiles primary tumors. Next, demonstrated expression...
Anti-CD19 chimeric antigen receptor (CAR) T cells have shown promise in the treatment of B cell acute lymphocytic leukemia (B-ALL). However, its efficacy B-ALL patients with extramedullary involvement is limited due to poor responses and neurotoxicity. Here, we utilized a third generation CAR vector, which contains Toll/interleukin-1 (ITR) domain Toll-like 2 (TLR2), generate 1928zT2 targeting CD19, evaluated relapse or refractory involvement. were generated by 19-28z-TLR2 lentiviral vector...
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with few treatment options. The poor success in developing anti-IPF strategies has impelled researchers to reconsider the importance of choice animal model and assessment methodologies. Currently, it still not settled whether bleomycin-induced mouse finally returns resolution. Methods This study aimed follow dynamic fibrotic features bleomycin-treated lungs over extended durations through combination latest technologies...
Multiple iterations of chimeric antigen receptors (CARs) have been developed, mainly focusing on intracellular signaling modules. However, the effect non-signaling extracellular modules expansion and therapeutic efficacy CARs remains largely undefined. We generated two versions CAR vectors, with or without a hinge domain, targeting CD19, mesothelin, PSCA, MUC1, HER2, respectively. Then, we systematically compared domains growth kinetics, cytokine production, cytotoxicity T cells in vitro...
The mouse is an organism that widely used as a mammalian model for studying human physiology or disease, and the development of immunodeficient mice has provided valuable tool basic applied disease research. Following large-scale knockout programs genome-editing tools, it become increasingly efficient to generate genetically modified strains with immunodeficiency. However, due lack standardized system evaluating immuno-capacity prevents tumor progression in mice, objective choice appropriate...
The Exocrine Differentiation and Proliferation Factor (EXDPF) gene could promote exocrine while inhibit endocrine functions. Although it is well known that ovary an organ, the functions of EXDPF in ovarian cancer development still unknown. This study demonstrated significantly higher expressed tumors compared to normal tissue controls. DNA amplification was exhibited lots human including 7.19% tumors. Also, high expression positively correlated with poor overall survival (OS) patients. be...
Immunodeficient mice engrafted with either normal or cancerous human cells are widely used in basic and translational research. In particular, NOD/SCID/IL2rg-/- can support the growth of various types cancer cells. However, hairs these interfere observation imaging tissues. Therefore, novel hairless strains exhibiting comparable immunodeficiency would be beneficial. Recently, CRISPR/Cas9 system has been for efficient multiplexed genome editing. present study, we generated a strain nude...
Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease with limited therapeutic options and high lethality, related to alveolar type II epithelial (ATII) cell dysregulation, the abnormal repair of cells activation fibroblasts promote development fibrosis. Fatty acid binding protein 1 (FABP1) was significantly downregulated in state by proteomics screening our previous date, ATII dysregulation can be mediated FABP1 via regulating fatty metabolism intracellular transport. The aim...
Kruppel-like factor 4 (KLF4) is a zinc finger transcription that can regulate diverse cellular physiological functions such as cell growth, death, differentiation, and migration. Recent studies have suggested KLF4 act either suppressor or oncogene for different types of cancers, ranging from solid tumors to leukemia, by regulating target genes involved in tumor proliferation, survival, metastasis, invasiveness, the constitution microenvironment. In most cancer types, has shown ability...
Abstract Chimeric antigen receptor (CAR) T cells have been successfully used to treat B cell malignancies, but faces many obstacles in solid tumors. A major challenge is the immune-suppressive effects induced by PD-L1 expression tumors and CD80/86 that ligate with CTLA-4 are expressed myeloid-derived immune suppressive cells. Dual blockade of PD-1 monoclonal antibodies has achieved promising anti-tumor clinics. Here, we designed two switch constructs. One contains truncated extracellular...