A5049849301- Microbial Natural Products and Biosynthesis
- ATP Synthase and ATPases Research
- Steroid Chemistry and Biochemistry
- Skin Protection and Aging
- GDF15 and Related Biomarkers
- Asthma and respiratory diseases
- Indoor Air Quality and Microbial Exposure
- Esophageal Cancer Research and Treatment
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
China-US (Henan) Hormel Cancer Institute
2021-2024
Esophageal squamous cell carcinoma (ESCC) is the predominant form of esophageal cancer and characterized by an unfavorable prognosis. To elucidate distinct molecular alterations in ESCC investigate therapeutic targets, we performed a comprehensive analysis transcriptomics, proteomics, phosphoproteomics data derived from 60 paired treatment-naive adjacent nontumor tissue samples. Additionally, conducted correlation to describe regulatory relationship between transcriptomic proteomic...
Abstract Background Although molecular targets such as HER2, TP53 and PIK3CA have been widely studied in esophageal cancer, few of them were successfully applied for clinical treatment. Therefore, it is urgent to discover novel actionable inhibitors. Eukaryotic translational elongation factor 2 (eEF2) reported be highly expressed various cancers. However, its contribution the maintenance progression cancer has not fully clarified. Methods In present study, we utilized tissue array evaluate...