A5100410556- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Renal cell carcinoma treatment
- Medical Imaging Techniques and Applications
- Vascular Procedures and Complications
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Neuroblastoma Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Microbial Natural Products and Biosynthesis
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Chronic Kidney Disease and Diabetes
- Estrogen and related hormone effects
- Cancer Mechanisms and Therapy
Wenzhou Medical University
2025
Hangzhou Medical College
2025
Jinzhou Medical University
2025
Zhejiang Provincial People's Hospital
2025
Fudan University
2016-2024
Zhongshan Hospital
2016-2024
Tongji University
2023-2024
Wuhan Institute of Virology
2024
Chinese Academy of Sciences
2019-2024
Yichang Central People's Hospital
2024
Abstract Esophageal squamous precancerous lesions (ESPL) are the precursors of esophageal cell carcinoma (ESCC) including low-grade and high-grade intraepithelial neoplasia. Due to absence molecular indicators, which ESPL will eventually develop into ESCC thus should be treated is not well defined. Indicators, for predicting risks at stages, an urgent need. We perform spatial whole-transcriptome atlas analysis, can eliminate other tissue interference by sequencing specific regions. In this...
Current clinical evaluation may tend to lack precision in detecting depression Parkinson's disease (DPD). Radiomics features have gradually shown potential as auxiliary diagnostic tools identifying and distinguishing different subtypes of (PD), a radiomic approach that combines unsupervised machine learning has the identify DPD. Analyze imaging data 272 (PD) patients from PPMI dataset, along with 45 PD NACC dataset. Extract T1-weighted MRI images employ principal component analysis (PCA) for...
ACTN1 belongs to the α-actinin family and is considered a tumor-promoting gene in various tumor types; however, biological function fundamental molecular mechanisms of ovarian cancer remain unclear. The HPA Cancer Genome Atlas (TCGA) databases were used compare expression normal OC tissues. Kaplan-Meier Plotter database was analyze relationship between prognosis cancer. TIMER2.0 correlation macrophages. CCK-8, colony formation, Transwell assays as well flow cytometry determine properties...
Abstract Background To evaluate the prognostic value of pre-treatment aspartate transaminase (AST)/alanine (ALT) ratio in hepatocellular carcinoma (HCC) patients receiving radiofrequency ablation (RFA)/microwave (MWA) combined with simultaneous TACE. Methods The data for 117 were retrospectively analyzed this study. endpoint prognosis was overall survival (OS). Youden index used to choose optimal cut-off AST/ALT OS prediction. Univariate and multivariate analyses identify independent risk...
The Nipah virus (NiV), a highly deadly bat-borne paramyxovirus, poses substantial threat due to recurrent outbreaks in specific regions, causing severe respiratory and neurological diseases with high morbidity. Two distinct strains, NiV-Malaysia (NiV-M) NiV-Bangladesh (NiV-B), contribute different geographical areas. Currently, there are no commercially licensed vaccines or drugs available for prevention treatment. In response this urgent need protection against NiV related henipaviruses...
Identification of fluid biomarkers for progressive supranuclear palsy (PSP) is critical to enhance therapeutic development. We implemented unbiased DNA aptamer (SOMAmer) proteomics identify novel CSF PSP biomarkers.
Abstract Background Hepatitis B virus (HBV) infection is one of the main leading causes hepatocellular carcinoma (HCC) worldwide. However, it remains uncertain how reverse-transcriptase (rt) gene contributes to HCC progression. Methods We enrolled a total 307 patients with chronic hepatitis (CHB) and 237 HBV-related from 13 medical centers. Sequence features comprised multidimensional attributes rt nucleic acid rt/s amino sequences. Machine-learning models were used establish predictive...
Bacillus cereus, a Gram-positive bacterium, is food contaminant that threatens the health of thousands people around world. Because continuous emergence drug-resistant strains, development new classes bactericides from natural products high priority. In this study, two novel cassane diterpenoids (pulchins A and B) three known ones (3-5) were elucidated medicinal plant Caesaplinia pulcherrima (L.) Sw. Pulchin A, with rare "6/6/6/3" carbon skeleton, showed significant antibacterial activity...
Percutaneous thermal ablation combined with transarterial chemoembolization (TACE) becomes a treatment option for unresectable hepatocellular carcinoma (HCC). This study aims to investigate the safety and feasibility of percutaneous simultaneous TACE patients HCC ≤ 5 cm.From June 2010 February 2017, total 280 cm who underwent were included in our study. Their clinical data collected analyzed.Major complications occurred five cases (1.8%). The complete necrosis rate was 91.9%. median overall...
The quality of oocytes determines their development competence, which will be rapidly lost if the are not fertilized at proper time after ovulation. SIRT1, one sirtuin family members, has been proven to protect during postovulatory oocyte aging. However, evidence effect SIRT1 on activity organelles including mitochondria, endoplasmic reticulum (ER), Golgi apparatus, and lysosomes in aging is lacking. In this study, we investigated distribution function aged discovered abnormalities....
ABSTRACT Lassa virus (LASV) is the causative agent of human fever which in severe cases manifests as hemorrhagic leading to thousands deaths annually. However, no approved vaccines or antiviral drugs are currently available. Recently, we screened approximately 2,500 compounds using a recombinant vesicular stomatitis (VSV) expressing LASV glycoprotein GP (VSV-LASVGP) and identified P-glycoprotein inhibitor potential entry inhibitor. Here, show that another candidate, hexestrol (HES), an...
SARS-CoV-2 evolves gradually to cause COVID-19 epidemic. One of driving forces evolution might be activation apolipoprotein B mRNA editing catalytic subunit-like protein 3 (APOBEC3) by inflammatory factors. Here, we aimed elucidate the effect APOBEC3-related viral mutations on infectivity and immune evasion SARS-CoV-2. The C>U ranked as second most common mutation types in genome. expression APOBEC3A (A3A), APOBEC3B (A3B), APOBEC3G (A3G) peripheral blood cells increased with disease...
Aim To compare the effectiveness and safety of transjugular intrahepatic portosystemic shunt (TIPS) with endoscopic therapy plus non-selective β-blockers (NSBBs) for secondary prevention gasroesophageal variceal bleeding (GEVB) in cirrhotic patients high-risk factors treatment failure. Methods material: A total 122 history high including hepatic vein pressure gradient (HVPG) ≥ 20 mmHg, portal thrombosis (PVT), gastrorenal (GRS), or extraluminal para-gastric veins (ep-GVs) detected by...