A5103109324- Hepatitis B Virus Studies
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Berberine and alkaloids research
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Quinazolinone synthesis and applications
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Cancer-related Molecular Pathways
- Drug Solubulity and Delivery Systems
- Wastewater Treatment and Nitrogen Removal
- PI3K/AKT/mTOR signaling in cancer
University Medical Center Groningen
2019-2025
University of Groningen
2019-2025
First Affiliated Hospital of Xiamen University
2025
Guangxi University
2025
Hunan Cancer Hospital
2022-2024
Central South University
2022-2024
China Medical University
2024
Second Xiangya Hospital of Central South University
2024
Third Xiangya Hospital
2023
Eastern Hepatobiliary Surgery Hospital
2017-2022
M2-like tumor-associated macrophages promote tumor progression by establishing an immunosuppressive microenvironment. The phenotype and activity of are related to their mitochondrial metabolism. Thus, we studied if drugs targeting metabolic pathways can repolarize from M2 into M1-like or prevent M0-to-M2 polarization. selected clinically approved in clinical trials target M2-specific pathways: fatty acid oxidation (Perhexiline Trimetazidine), glutaminolysis (CB-839), PPAR activation (HX531),...
Abstract BRD7 functions as a crucial tumor suppressor in numerous malignancies including nasopharyngeal carcinoma (NPC). However, its function and exact mechanisms involved progression are not well understood. Here, we found that the B7BS was potential enhancer region of BIRC2, negatively regulated transcriptional activity expression BIRC2 by targeting activation enhancer. Moreover, promoted cell proliferation, migration, invasion xenograft growth metastasis vivo, thus functioning an...
Mitophagy is a selective autophagy targeting damaged and potential cytotoxic mitochondria, which can effectively prevent excessive production from mitochondria alleviate the inflammatory response. However, role of mitophagy in sepsis remains poorly explored. Here, we studied its immune heterogeneity. By performing mitophagy-related typing on 348 samples, three clusters (A, B, C) were obtained. Cluster A had highest degree accompanied by lowest disease severity, while cluster C with severity....
To explore the apoptotic effects and underlying mechanisms of nitidine chloride (NC) in epithelial ovarian cancer.The MTT cell proliferation assay was used to detect inhibitory different concentrations NC (0, 0.3125, 0.625, 1.25, 2.5, 5 10 μg/ml) SKOV3 carcinoma cells. The number cells observed by Hoechst staining measured flow cytometry. Quantitative PCR measure expression Fas, Fas-associated death domain-containing protein (FADD), caspase-8 caspase-3. RNA interference (RNAi) determine...
Several different mechanisms are implicated in the resistance of lung cancer cells to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), and only few have been functionally investigated. Here, using genetically knocked out EGFR TKI-resistant cells, we show that loss wild-type attenuates cell proliferation, migration 3D-spheroid formation, whereas mutant or TKIs reinforces those processes. Consistently, disruption leads suppression HER2/HER3, while ablation increases...
Purpose: Cinobufotalin injection has obvious curative effects on liver cancer patients with less toxicity and fewer side than other therapeutic approaches.However, the core ingredients mechanism underlying these anti-liver have not been fully clarified due to its complex composition.Methods: Multidimensional network analysis was used screen ingredients, key targets pathways of cinobufotalin cancer, in vitro vivo experiments were performed confirm findings.Results: By construction ingredient...
Abstract Background Hepatitis B virus (HBV) infection is one of the main leading causes hepatocellular carcinoma (HCC) worldwide. However, it remains uncertain how reverse-transcriptase (rt) gene contributes to HCC progression. Methods We enrolled a total 307 patients with chronic hepatitis (CHB) and 237 HBV-related from 13 medical centers. Sequence features comprised multidimensional attributes rt nucleic acid rt/s amino sequences. Machine-learning models were used establish predictive...
Current knowledge on apolipoprotein A1 (APOA1) in hepatocellular carcinoma (HCC) is fragmented and even contradictory. Multi-dimensional analyses are required to comprehensively elucidate its value underlying mechanism.We collected 49 RNA-seq datasets, 40 cell line types data 70 scRNA pan-cancer datasets public available, including 17 HCC (1754 tumor samples), enrolled 73 pairs of tissue 516 blood samples independently from our clinics. APOA1 impacting the microenvironment (TME) was analyzed...
Abstract BRD7 was identified as a tumor suppressor in nasopharyngeal carcinoma (NPC). Circular RNAs (CircRNAs) are involved the occurrence and development of NPC oncogenes or suppressors. However, function mechanism circular RNA forms derived from not well understood. In this study, we first that circBRD7 novel circRNA inhibited cell proliferation, migration, invasion cells, xenograft growth metastasis vivo. Mechanistically, promoted transcriptional activation expression by enhancing...
The aim of the present study was to investigate cytotoxic effects and underlying molecular mechanisms nitidine chloride (NC) in hepatocellular carcinoma cells via quantitative proteomics. MTT assays were used detect inhibitory NC Bel-7402 liver cancer cells, number apoptotic measured by flow cytometry. Quantitative proteomics technology based on iTRAQ discover differential expressed proteins after treatment, bioinformatic techniques further screen potential targets NC. Molecular docking...
NOP2/Sun RNA methyltransferase 2 (NSUN2), an important of m5C, has been poorly studied in cancers, and the relationship between NSUN2 immunity remains largely unclear. Therefore, purpose this study was to explore expression prognostic value role cancers.
In order to investigate if deletion patterns of the preS region can predict liver disease advancement, hepatitis B virus (HBV) genome in 45 chronic (CHB) and 94 HBV-related hepatocellular carcinoma (HCC) patients was sequenced by next-generation sequencing (NGS) percentages nucleotide were analysed. Hierarchical clustering heatmaps based on revealed different between CHB HCC patients. Intergenotype comparison also indicated divergence deletions HBV genotype C. No significant difference found...
Background This study aimed to explore the molecular mechanism of coexistence hepatitis B surface antigen (HBsAg) and antibody (HBsAb) serological pattern via intensive characterization HBV s gene in both chronic (CHB) hepatocellular carcinoma (HCC) patients. Method A total 73 HBsAg+/HBsAb+ patients (CHB = 36, HCC 37) 96 HBsAg+/HBsAb− 47, 49) were enrolled from 13 medical centers China. The sequence features elaborated based on combination next-generation sequencing (NGS) multidimensional...
The aim of this study was to explore the relationship between hepatitis B virus (HBV) core antigen (HBc) mutations and post-operative prognosis HBV-related hepatocellular carcinoma (HCC). In total, 98 patients suffering from HCC treated with surgery were enrolled, a 48 month follow-up. preCore/Core region HBV genome tumour tissue (TT) paired adjacent non-tumour (ANTT) these sequenced, phylogenetic tree reconstructed. correlations viral features evolutionary divergence amino acid sequences 67...