A5086341646- Berberine and alkaloids research
- Quinazolinone synthesis and applications
- Cancer Mechanisms and Therapy
- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Curcumin's Biomedical Applications
- Essential Oils and Antimicrobial Activity
- Acupuncture Treatment Research Studies
- Pesticide Residue Analysis and Safety
- Cancer, Hypoxia, and Metabolism
- Sleep and related disorders
- Metabolomics and Mass Spectrometry Studies
- Alkaloids: synthesis and pharmacology
- Bone Metabolism and Diseases
- Computational Drug Discovery Methods
- Phytochemical compounds biological activities
- Iron and Steelmaking Processes
- Plant chemical constituents analysis
- Cardiac Fibrosis and Remodeling
- Mental Health Research Topics
- Congenital heart defects research
- Ziziphus Jujuba Studies and Applications
- Toxic Organic Pollutants Impact
- Forensic Toxicology and Drug Analysis
- Adipokines, Inflammation, and Metabolic Diseases
Karolinska Institutet
2024
Guangxi Medical University
2011-2023
Jianghan University
2019
Peking University
2012
Centers for Disease Control and Prevention
2007
National Center for Environmental Health
2007
A method was developed for the quantitative analysis of 30 drugs abuse and their metabolites in urine, including opiates, barbiturates, amphetamines, cocaine, cannabinoids, phencyclidine, methadone, benzodiazepines. This uses solid-phase extraction (SPE) on an Oasis HLB column followed by liquid chromatography-tandem mass spectrometry. Analytes were quantified multiple reaction monitoring with deuterated analogues as internal standards, using atmospheric pressure ionization-electrospray...
Context Camellia nitidissima Chi (Theaceae) is an evergreen shrub, the leaves of which are used in many medicinal applications.Objective To characterize chemical composition a 10% aqueous ethanol extract C. (CNE), and to explore protective effect against acute liver injury (ALI) rats.Materials methods Male Sprague-Dawley rats were divided into six groups (n = 10): control negative (0.5% CMC-Na, 5 mL/kg/d), thiopronin (20 mg/kg/d) CNE (40, 80 160 mg/kg/d). All treated for seven consecutive...
To explore the apoptotic effects and underlying mechanisms of nitidine chloride (NC) in epithelial ovarian cancer.The MTT cell proliferation assay was used to detect inhibitory different concentrations NC (0, 0.3125, 0.625, 1.25, 2.5, 5 10 μg/ml) SKOV3 carcinoma cells. The number cells observed by Hoechst staining measured flow cytometry. Quantitative PCR measure expression Fas, Fas-associated death domain-containing protein (FADD), caspase-8 caspase-3. RNA interference (RNAi) determine...
Curcuma aromatica is used as a traditional Chinese medicine, and it mainly distributed in Guangxi, China. In this study, 10 batches of C. were collected from different origins Guangxi. The fingerprints established by HPLC technique to investigate the quality stability aromatica. spectrum-effect relationship between hypolipidemic effect was assessed similarity analysis, gray relational analysis multiple linear regression analysis. From results, values each batch reference fingerprint >0.880,...
A classic traditional Chinese medicine Curcuma aromatica Salisb. (Zingiberaceae) has been reported to have favourable effects on the cardiovascular system.To research cardio-protective effect of different C. hydroalcoholic extracts isoproterenol (ISO)-induced acute myocardial ischemia (AMI) in rats. The total phenols were detected simultaneously.The rhizomes dry powder refluxed with 30%, 50%, 70% and 90% solvents obtain extracts. Rats pretreated four (150 mg/kg/day, i.g.) for 9 days then...
The aim of the present study was to investigate cytotoxic effects and underlying molecular mechanisms nitidine chloride (NC) in hepatocellular carcinoma cells via quantitative proteomics. MTT assays were used detect inhibitory NC Bel-7402 liver cancer cells, number apoptotic measured by flow cytometry. Quantitative proteomics technology based on iTRAQ discover differential expressed proteins after treatment, bioinformatic techniques further screen potential targets NC. Molecular docking...
To evaluate the role of polysaccharide from Phellinus igniarius (PPI) in improvement oxidative stress, hepatic granuloma and fibrosis Schistosoma japonicum-iniected mice.The mouse model schistosomiasis was established by S. japonicum cercariae infection via abdomen. Balb/c mice were randomly assigned into 5 groups, including healthy control group (Group A), B), PPI treatment C), praziquantel D) PPI-praziquantel combination E), 10 each group. Each groups B, C, D E infected with (30 ± 2)...
Diabetic wound is one of the most severe complications diabetes mellitus (DM). Despite associated risks healing impairment in diabetes, treatment strategies remain limited. Yeliangen (YLG) a Chinese formulation mainly composed rhizome Coptis chinensis, root Isatis tinctoria, and leaf indigotica. We investigated effects YLG type 2 diabetic (T2DM) rats, which were induced by intraperitoneal administration streptozotocin after high-fat diet for four weeks. 3 × cm2 full-thickness excisional...
Zanthoxylum nitidum (Roxb.) DC was used in many Chinese prescriptions. In this study, based on the infrared fingerprints of Z. collected from different regions, two mathematical models were successfully established to evaluate anticancer effects roots extracts BEL-7404 and HepG-2 hepatocellular carcinoma cells. Arguments obtained by backward-elimination method adopted as an evaluation tool establish spectrum-effect correlation between pharmacological data. Two tumor cells inhibited...