A5011776066- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glycosylation and Glycoproteins Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Catalysis and Hydrodesulfurization Studies
- IgG4-Related and Inflammatory Diseases
- Lignin and Wood Chemistry
- Wound Healing and Treatments
- vaccines and immunoinformatics approaches
- Text and Document Classification Technologies
- Psoriasis: Treatment and Pathogenesis
- Platelet Disorders and Treatments
- Lysosomal Storage Disorders Research
Shanghai University of Traditional Chinese Medicine
2021-2025
University Hospital Heidelberg
2025
Heidelberg University
2025
University Medical Centre Mannheim
2025
Yueyang Hospital
2021-2024
Southwest Jiaotong University
2022-2024
Nanjing Medical University
2022
Jiangsu Province Hospital
2022
Eastern Hepatobiliary Surgery Hospital
2020-2021
Second Military Medical University
2020-2021
Abstract Background GALAD is an algorithm model estimating the presence of hepatocellular carcinoma (HCC). However, participants enrolled in differ from those Chinese subjects whose HCCs are mainly hepatitis B virus infection related. Therefore, cross‐sectional as well longitudinal multicenter study was designed to assess clinical performances population. Methods A case‐control 602 patients with HCC (34.10% within Barcelona Clinic Liver Cancer 0‐A stage) and 923 without five medical centres...
Alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (ANHCC) patients account for more than 30% of the whole entity HCC and are easily misdiagnosed. This three-phase study was designed to find validate new ANHCC N-glycan markers which identified from The Cancer Genome Atlas (TCGA) database noninvasive detection. Differentially expressed genes (DEGs) biosynthesis degradation related were screened TCGA database. Serum structure abundances analyzed using fingerprint (NGFP) technology....
Abstract Background Hepatitis B virus (HBV) infection is one of the main leading causes hepatocellular carcinoma (HCC) worldwide. However, it remains uncertain how reverse-transcriptase (rt) gene contributes to HCC progression. Methods We enrolled a total 307 patients with chronic hepatitis (CHB) and 237 HBV-related from 13 medical centers. Sequence features comprised multidimensional attributes rt nucleic acid rt/s amino sequences. Machine-learning models were used establish predictive...
Current knowledge on apolipoprotein A1 (APOA1) in hepatocellular carcinoma (HCC) is fragmented and even contradictory. Multi-dimensional analyses are required to comprehensively elucidate its value underlying mechanism.We collected 49 RNA-seq datasets, 40 cell line types data 70 scRNA pan-cancer datasets public available, including 17 HCC (1754 tumor samples), enrolled 73 pairs of tissue 516 blood samples independently from our clinics. APOA1 impacting the microenvironment (TME) was analyzed...
Abstract Predictive prognostic markers for immunotherapy are crucial and desperately required clinical precise medicine. This retrospective study aimed to assess the efficacy of anti-PD-1 (programmed cell death protein 1) treatment find therapeutic biomarkers in advanced biliary tract cancer (BTC). A total 60 patients BTC who received at least one dose therapy between June 2016 October 2019 were recruited followed up till April 2020. Systemic immune-inflammation index (SII)...
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two main types of primary liver cancer, reliable discrimination is important for optimal treatment. Aberrant glycosylation was detected in HCC ICC. Both cross-sectional follow-up studies were performed to establish a differential diagnosis model using N-glycans. A total 420 participants enrolled, with 310 patients training cohort 110 validation cohort. The used assess the prognosis As results, diagnostic efficacy...
Background HPV-16 infection and viral-host integration are the most important risk factors for cervical cancer (CC). The aim of this study is to develop a new molecular strategy integrated both viral host genome variations identifying monitoring CC.
Abstract Background Glycosylation is an important post‐translational modification of protein. The change in glycosylation involved the occurrence and development various diseases, this study verified that N ‐glycan markers might be a diagnostic marker psoriasis. Methods A total 76 psoriasis patients were recruited. We used Psoriasis Area Severity Index (PASI) scores to evaluate state psoriasis, 41 whom divided into three subgroups: mild, moderate, severe. At same time, healthy subjects...
Background This study aimed to explore the molecular mechanism of coexistence hepatitis B surface antigen (HBsAg) and antibody (HBsAb) serological pattern via intensive characterization HBV s gene in both chronic (CHB) hepatocellular carcinoma (HCC) patients. Method A total 73 HBsAg+/HBsAb+ patients (CHB = 36, HCC 37) 96 HBsAg+/HBsAb− 47, 49) were enrolled from 13 medical centers China. The sequence features elaborated based on combination next-generation sequencing (NGS) multidimensional...
Abstract Background Primary hepatocellular carcinoma (HCC) is one of the most prevalent world‐wide malignancies. Half newly developed HCC occurs in China. Optimizing strategies for high‐risk surveillance and early diagnosis are pivotal improving 5‐year survival. Constructing scientific non‐invasive detection technologies feasible medical healthcare institutions among key routes elevating efficacies identification follow‐up. Results Based on Chinese international guidelines, expert consensus...
Selective catalytic reduction (SCR) systems are important technical means of mitigating NOx emissions for diesel engines. The major challenge this technique is to improve the low-temperature activity catalyst during engine cold start and thermal stability on repeated exposure high-temperature exhaust. A two-stage SCR system with a Cu-SSZ-13 was analyzed sample experiments NH3 oxidation experiments. effects copper content, doping metals, structural arrangement, NO2/NOx ratio, NH3/NOx ratio...
Wilson disease (WD) is a rare autosomal recessive genetic disorder associated with various mutations in the ATP7B gene and leads to significant disability or death if untreated. Early diagnosis proper therapy usually predict good prognosis, especially pre-symptomatic WD. Genetic testing provides an accurate effective diagnostic method for early of WD.We recruited 18 clinically diagnosed WD patients from 16 unrelated families two independent individuals. The next-generation sequencing was...
Abstract Objective Biliary tract cancer (BTC) is a rare malignancy and lack of effective diagnostic prognostic marker. Here, we aimed to investigate the clinical implication TP53 mutation detection in BTC using droplet digital PCR (ddPCR). Methods gene (loci p.R175H, p.R248Q, p.R248W, p.R273H) frequencies 45 pairs tumor tissues (TTs) adjacent normal (ANTTs) were analyzed, respectively, ddPCR. Meanwhile, same detections conducted plasma cell‐free DNA (cfNDA) 156 subjects including BTC,...
The glycosylation alterations of serum and IgG are involved in a variety autoimmune inflammatory diseases have shown great potential biomarker field. diagnosis immune thrombocytopenia (ITP) is exclusive. Our study aimed to discover the glyco-biomarkers for auxiliary ITP.The samples were obtained from 61 ITP patients 35 healthy controls, purified 34 out controls. DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) was used analyze N-glycan profiling.6 12 peaks,...
Purpose: Early detection of hepatocellular carcinoma (HCC) through surveillance could reduce this cancer-associated mortality. We aimed to develop and validate algorithms using panel serum biomarkers identify HCC in a real-world multi-center study China. Patients Methods: A total 10,359 eligible subjects, including HCCs benign liver diseases (BLDs), were recruited from six Chinese medical centers. The three nomograms built logistic regression their sensitivities specificities carefully...
Stenosis severity may escalate over the course of coronary artery disease (CAD), increasing risk death for patient. Conventionally, assessment stenosis degree relies on invasive angiography (ICA), an examination unsuitable patients in poor physical condition or those with contrast allergies and one that imposes a psychological burden patients. Although abnormal serum N-glycan profiles have exhibited robust associations various cardiovascular diseases, including CAD, their potential...
Changes in the expression of genes related to glycosyltransferases may lead alterations N-glycan structure abundance, potentially acting as markers for diagnosis and prognosis biliary tract cancer (BTC).