A5004470429- MicroRNA in disease regulation
- Topic Modeling
- Circular RNAs in diseases
- Software Engineering Research
- Natural Language Processing Techniques
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Intracranial Aneurysms: Treatment and Complications
- Inflammasome and immune disorders
- Animal Nutrition and Physiology
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Traumatic Brain Injury and Neurovascular Disturbances
- Tryptophan and brain disorders
- Lipid metabolism and disorders
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Genetic and phenotypic traits in livestock
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Fujian Medical University
2015-2024
First Affiliated Hospital of Fujian Medical University
2015-2024
University of Leicester
2024
CCCC Wuhan Harbour Engineering Design and Research (China)
2024
Yangzhou University
2018-2022
University of British Columbia
2022
Kootenay Association for Science & Technology
2021
Korea Advanced Institute of Science and Technology
2021
Plant-derived extracellular vesicles (PDEVs) have great potential for clinical applications. Ultracentrifugation, considered the gold standard method preparation of PDEVs, is efficacious but time-consuming and highly instrument-dependent. Thus, a rapid handy needed to facilitate basic researches applications PDEVs. In this study, we combined electrophoretic technique with 300 kDa cut-off dialysis bag (named ELD) isolation which was time-saving no special equipment. Using ELD, lemon derived...
5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, chemoresistance tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored role NLRP3 inflammasome in resistance oral squamous cell carcinoma (OSCC). The mRNA and protein expression levels NLRP3, Caspase1 IL-1β resected OSCC specimens or lines were measured respectively by quantitative real time-PCR (qRT-PCR) western blot. Ki-67 paraffin-embedded tissues was determined...
Inflammasomes are reported to be abnormally expressed and activated in several malignancies play important roles tumor development. The present study was designed investigate the expression function of NLR family pyrin domain containing protein 3 (NLRP3) inflammasome oral squamous cell carcinoma (OSCC). NLRP3 OSCC lines normal human immortalized epithelial cells (HIOEC) determined by real-time PCR western blot. Immunohistochemistry used examine IL-1β paraffin-embedded tissues. proliferation...
Plant-derived extracellular vesicles (PDEVs) have been exploited for cancer treatment with several benefits. Bitter melon is cultivated as a vegetable and folk medicine anticancer anti-inflammatory activities. 5-Fluorouracil (5-FU) widely used treatment. However, 5-FU-mediated NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammation activation induced the resistance of oral squamous cell carcinoma (OSCC) cells to 5-FU. In this study, we explored potential bitter melon-derived...
Circular RNA (circRNA) is a type of noncoding involved in variety biological processes, especially post-transcriptional regulation. The granulosa cells follicles play determining role ovarian development. However, the function circRNA chicken unclear. To better understand molecular mechanism underlying follicular development and cell function, we performed strategy second-generation sequencing linear depletion for from small yellow (SYF, 5–8 mm), smallest hierarchal (F6, 9–12 largest (F1, ~...
Considerable evidence has linked periodontitis (PD) to hypertension (HTN), but the nature behind this connection is unclear. Dysbiosis of oral microbiota leading PD known aggravate different systematic diseases, alteration in HTN and their impacts on blood pressure (BP) remains be discovered.To characterize alterations gut roles HTN.We performed a cross-sectional (95 participants 39 controls) 6-month follow-up study (52 26 analyze HTN. Saliva, subgingival plaques, feces were collected for...
Abstract Background Metformin, which is widely used as an antidiabetic agent, has recently been reported to reduce cancer risk and improve prognosis in certain malignancies. However, the specific mechanisms underlying effect of metformin on development progression several cancers including oral squamous cell carcinoma (OSCC) remain unclear. In present study, we investigated effects OSCC cells vitro vivo . Methods treated with or without were counted using a hemocytometer. The clonogenic...
Abstract Background Toll-like receptor 4 (TLR4) is expressed on immune cells as a sensor that recognizes lipopolysaccharide (LPS), microbial conserved component. It has recently been determined the expression of TLR4 also found in various types tumor cells. Cisplatin widely used chemotherapeutic agent for oral squamous cell carcinoma (OSCC) treatment. However, mechanisms responsible cisplatin resistance are not well understood. Results The present study was designed to elucidate role human...
MicroRNAs (miRNAs) have been implicated as important regulators of carcinogenesis and tumor development. Recently, microRNA‐22 (miR‐22) has reported to be a cancer‐related miRNA in several types tumors. In this study, we aimed investigate the role miR‐22 oral squamous cell carcinoma (OSCC). We found that expression was significantly decreased OSCC tissues compared with adjacent noncancerous tissues. Furthermore, lentivirus‐mediated overexpression markedly reduced viability, migration...
Dermal γδT cells play critical roles in skin homeostasis and inflammation. However, the underlying molecular mechanisms by which these are activated have not been fully understood. Here, we show that mechanistic or mammalian target of rapamycin (mTOR) STAT3 pathways dermal response to innate stimuli such as interleukin-1β (IL-1β) IL-23. Although both mTOR complex 1 (mTORC1) mTORC2 essential for cell proliferation, deficiency leads decreased γδT17 cells. It appears mitochondria-mediated...
Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification material unequal segregation, associated with poor cancer patients' prognosis. The ability immune evasion typical feature for progression, however the intrinsic factors that determine remain poorly understood. Here we show presence ecDNA markers evasion, obtaining could be one mechanisms employed by cells escape...
Maintaining the functional integrity of mitochondria is crucial for cell function, signal transduction and overall activities. Mitochondrial dysfunctions may alter energy metabolism in many cases are associated with neurological diseases. Recent studies have reported that mutations dehydrogenase E1 transketolase domain‐containing 1 ( DHTKD1 ), a mitochondrial protein encoding gene, could cause abnormalities. However, function remains unknown. Here, we report strong correlation expression...
A recent study by Ahmed and Devanbu reported that using a corpus of code written in multilingual datasets to fine-tune Pre-trained Language Models (PLMs) achieves higher performance as opposed just one programming language. However, no analysis was made with respect fine-tuning monolingual PLMs. Furthermore, some languages are inherently different language usually cannot be interchanged the others, i.e., Ruby Java possess very structure. To better understand how PLMs affect languages, we...
Copy number alterations (CNAs) are a predominant source of genetic in human cancer and play an important role progression. However comprehensive understanding the mutational processes signatures CNA is still lacking. Here we developed mechanism-agnostic method to categorize based on various fragment properties, which reflect consequences mutagenic can be extracted from different types data, including whole genome sequencing (WGS) single nucleotide polymorphism (SNP) array. The 14 have been...
Regulatory T cells (Tregs) play an immunosuppressive role in tumor microenvironment (TME) various of cancer types. However, how different Treg subsets influence and effect on head neck squamous cell carcinoma (HNSCC) remain unclear. Here, using single-cell RNA sequencing (scRNA-seq), we identified IL1R2+Treg subset which promoted the progression HNSCC. Via tissue microassay (TMA) enzyme-linked immunosorbent assay (ELISA), verified clinical diagnostic value soluble IL1R2 (sIL1R2). In...
Eclipta prostrata L. is a traditional Chinese herbal medicine that has been used in the treatment of liver diseases. However, its biological mechanisms remain elusive. The current study aimed to investigate hepatoprotective effect wedelolactone, major coumarin ingredient L., on immune-mediated injury. Using well-established animal model Concanavalin A (ConA)-induced hepatitis (CIH), we found pretreatment mice with wedelolactone markedly reduced both serum levels transaminases and severity...
Many recent models in software engineering introduced deep neural based on the Transformer architecture or use transformer-based Pre-trained Language Models (PLM) trained code. Although these achieve state of arts results many downstream tasks such as code summarization and bug detection, they are PLM, which mainly studied Natural Processing (NLP) field. The current studies rely reasoning practices from NLP for code, despite differences between natural languages programming languages. There...
Small ubiquitin-like modifier (SUMO) modification is an important post-translational protein that can be reversed by SUMO-specific proteases (SENPs); however, the physiological function of SENPs remains largely unexplored, and little known about regulation themselves. As one crucial members SUMO system, SENP3 essential for rRNA processing cell proliferation. In present study, we analysed expression in human oral squamous carcinoma (OSCC) investigated correlation between its...