A5100642001- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vestibular and auditory disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Hearing, Cochlea, Tinnitus, Genetics
- MicroRNA in disease regulation
- Pancreatitis Pathology and Treatment
- Cardiac Valve Diseases and Treatments
- Extracellular vesicles in disease
- Tryptophan and brain disorders
- Infective Endocarditis Diagnosis and Management
- Neuroscience of respiration and sleep
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cerebral Venous Sinus Thrombosis
- MRI in cancer diagnosis
- Circadian rhythm and melatonin
- Inflammatory Biomarkers in Disease Prognosis
- Visual perception and processing mechanisms
- Neural and Behavioral Psychology Studies
- Color perception and design
- Sirtuins and Resveratrol in Medicine
Beijing Shijitan Hospital
2025
Capital Medical University
2025
Zhongshan Hospital
2010-2024
Fudan University
2010-2024
Shanghai Institute of Hematology
2018-2024
Sun Yat-sen University
2011-2024
The First Affiliated Hospital, Sun Yat-sen University
2011-2024
Huazhong University of Science and Technology
2024
Union Hospital
2024
National Clinical Research Center for Digestive Diseases
2024
MicroRNAs are potentially very useful biomarkers in the diagnosis of cancer. We sought to identify specific microRNAs peripheral blood mononuclear cells (PBMCs) whose levels might facilitate pancreatic investigated PBMC microRNA expression three independent cohorts [healthy, benign pancreatic/peripancreatic diseases (BPD), and cancer], comprising a total 352 participants. First, we used sequencing technology differentially expressed cancer, BPD, healthy controls (n = 20 each group). Then...
Pancreatic cancer is amongst the most lethal malignancies with increasing incidence and mortality worldwide. Distant metastases, especially intrahepatic leading cause of death for pancreatic cancer. Circulating tumor cells (CTCs) are neoplastic released from primary into circulation, play critical roles in metastases various types cancers. Though clinical studies showed that detection CTCs peripheral circulation was associated worse prognosis patients breast hepatocellular carcinoma, blood...
This study is sought to evaluate the feasibility and safety of using 125I seed strands for intraluminal brachytherapy (ILBT) in treatment malignant obstructive jaundice (MOJ), its clinical effect on stent patency. A total 34 patients found have MOJ were randomly assigned an ILBT group or a control before biliary insertion. For group, implanted into segment bile duct after only was inserted. Alimentary hematologic complications examined group. The patency two groups compared. In number seeds...
Chemokine (C-X-C motif) ligand 6 (CXCL6), a member of the CXC chemokine family, reportedly mediates several processes such as inflammation, immunoreaction, cell growth, and metastasis through interaction with receptors CXCR1 CXCR2 in humans; further, can promote repair regeneration organs or tissues after ischemia–reperfusion injury (IRI). In this study, we found that HIF-1α, CXCL6, expression levels were elevated human brain microvascular endothelial cells (HBMECs) IRI, whereas silent...
The disruption of mitochondrial redox homeostasis in endothelial cells (ECs) can cause chronic inflammation, a substantial contributor to the development atherosclerosis. Chronic sympathetic hyperactivity enhance oxidative stress induce dysfunction. We determined if renal denervation (RDN), strategy reducing tone, protect ECs by ameliorating reactive oxygen species (ROS)-induced inflammation reduce ApoE deficient (ApoE−/-) mice were conducted RDN or sham operation before 20-week high-fat...
Abstract Base editing tools with diversified scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) display constrained efficient at positions 4-8. Here, functional ABE variants reduced identified using domain insertion profiling inside SpCas9 different combinations of TadA variants. Engineered in this study narrowed, expanded or shifted across protospacer 2-16. And when...
Abstract OBJECTIVES A bicuspid aortic valve (BAV) is characterized by variable phenotypic manifestations, as well longitudinal evolution of dysfunction and ascending aorta dilatation. The present study investigated the impact severe stenosis (AS) on flow patterns wall shear stress (WSS) distribution in BAV patients with right–left (RL) right-non-coronary (RN) cusp fusion types, aimed to reveal whether could further alter intrinsic haemodynamic aberrations generated abnormal patterns. METHODS...
To validate the prognostic value of lactic dehydrogenase to albumin ratio (LAR) in patients with unresectable pancreatic cancer treated by intervention chemotherapy.There were 139 retrospectively analyzed this study. The survival was depicted Kaplan-Meier curves and calculated log-rank test. We used Cox proportional hazards regression model univariate multivariate analyses, integrated all independent risk factors establish nomogram.Patient higher LAR group had poorer overall (OS). Tumor,...
Abstract Chemokines and inflammatory response of endothelial cells is crucial in the development progression disease. Lipopolysaccharide (LPS) a well‐known factor to trigger induce damage cells. The present study used lipopolysaccharide (LPS)‐treated human vascular (HUVECs) investigate function chemokine CXC ligand 4 (CXCL4) its receptor 3 (CXCR3) inflammatory‐induced injury. LPS exposure (50, 100, 200 ng/ml) HUVECs induced dose‐ time‐dependent increase CXCL4 CXCR3 expression at both mRNA...
Percutaneous thermal ablation combined with transarterial chemoembolization (TACE) becomes a treatment option for unresectable hepatocellular carcinoma (HCC). This study aims to investigate the safety and feasibility of percutaneous simultaneous TACE patients HCC ≤ 5 cm.From June 2010 February 2017, total 280 cm who underwent were included in our study. Their clinical data collected analyzed.Major complications occurred five cases (1.8%). The complete necrosis rate was 91.9%. median overall...
Background Stent occlusion by tumor ingrowth or overgrowth is the main cause of jaundice recurrence after metal stent insertion in patients with malignant obstructive (MOJ). The application intraluminal brachytherapy (ILBT) MOJ results local control tumors, which prolong patency. Purpose To evaluate safety ILBT pig bile ducts using ribbons iodine-125 ( 125 I) seeds. Material and Methods Sixteen healthy pigs were randomly assigned to four groups each. A I seed ribbon was implanted into common...
Background: A modified European Neuroendocrine Tumor Society (mENETS) staging system has been confirmed to be more suitable for pancreatic neuroendocrine tumors (pNETs) when compared the American Joint Committee on Cancer (AJCC) or (ENETS) systems in last few years.However, importance of N stage recently published with several significant updates.Methods: SEER registry (n = 2,209) was used evaluate application AJCC 7th system, ENETS mENETS and reformed (rENETS) this study.Results: For...
To compare the efficacies of portal vein stenting and transcatheter arterial chemoembolization (TACE) combined therapy performed with or without endovascular implantation iodine-125 (125I) seeds strand in patients hepatocellular carcinoma (HCC) main tumor thrombus (MPVTT).One-hundred-and-six HCC complicated by MPVTT who were treated stents TACE, either (Group A, n=56) B, n=50) 125I strand, between July 2005 April 2011, retrospectively analyzed. Overall survival, stent patency,...
Au@PEI-Gd-AAG NP nanoprobes hold enormous promise for highly efficient tumor diagnosis and dual-mode CT/<italic>T</italic><sub>1</sub> positive MR imaging.