A5100414087- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Acute Ischemic Stroke Management
- Flavonoids in Medical Research
- Pharmacological Effects of Natural Compounds
- Microbial Metabolism and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemicals and Antioxidant Activities
- Brain Tumor Detection and Classification
- Natural product bioactivities and synthesis
- Saffron Plant Research Studies
- Tannin, Tannase and Anticancer Activities
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
- Sleep and Wakefulness Research
- Plant-based Medicinal Research
- Morinda citrifolia extract uses
- Atherosclerosis and Cardiovascular Diseases
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Plant Gene Expression Analysis
- Computational Drug Discovery Methods
- Medicinal Plants and Bioactive Compounds
- Plant biochemistry and biosynthesis
Jiangsu University
2024
Affiliated Hospital of Jiangsu University
2024
Xuzhou Cancer Hospital
2024
Sun Yat-sen University
2024
Fudan University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Tianjin Medical University General Hospital
2023
Tianjin Medical University
2023
Objective: The technology, network pharmacology and molecular docking technology of the ultra performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) were used to explore potential mechanism Platycodon grandiflorum (PG) in treatment lung cancer (LC). Methods: UPLC-Q-TOF-MS/MS was analyze ingredients PG LC targets obtained from Traditional Chinese Medicine Systems Pharmacology database, Analysis Platform (TCMSP), GeneCards other databases....
Citrus fruit contains rich nutrients which is edible and of officinal value. flavanones are widely used in the treatment cardiovascular other diseases, they a foundational material Chinese medicine. The chalcone-flavanone isomerase (CHI) plays key role flavanone synthesis. Therefore, we comprehensively analyzed CHI genes species. Here, thirty were identified for first time six species, divided into FAP groups. Evolutionary analysis showed that gene members highly conserved an ancient family....
Acute cerebral infarction profoundly affects patients' neurological function and quality of life. This study explores the impact Solitaire AB stent thrombectomy, combined with tirofiban butylphthalide, on inflammatory factors in patients acute infarction.
Through the method of network pharmacology, active components and targets Shenqi Wan (SQW) were excavated, relationship with novel Coronavirus pneumonia (COVID-19) was discussed, possible mechanism SQW in treatment COVID-19 revealed from aspects multicomponents, multitargets, multipathways.Firstly, screened traditional Chinese medicine systems pharmacology database analysis platform 2020 edition Pharmacopeia, related obtained. Then disease to GeneCards Online Mendelian Inheritance Man. Venny...
Major Depression Disorder (MDD) is a common mental disease that has become one of the world's major medical diseases. Currently, Fructus Aurantii (FA) been widely used to treat depression. However, active substance ingredients and potential mechanisms shell antidepression have not yet clarified.First, we ultraperformance liquid chromatography-quadrupole/time-of-flight tandem mass (UPLC-QTOF-MS/MS) technology identify chemical composition FA. Then, it predicted for ingredients, pharmaceutical...
Abstract Most patients that resuscitate successfully from cardiac arrest (CA) suffer poor neurological prognosis. DL‐3‐n‐butylphthalide (NBP) is known to have neuroprotective effects via multiple mechanisms. This study aimed investigate whether NBP can decrease impairment after CA. We studied the protective role of in hippocampus a rat model induced by asphyxia. Thirty‐nine rats were divided randomly into sham, control, and groups. Rats control groups underwent cardiopulmonary resuscitation...
Background and objective The injury of the cholinergic white matter pathway underlies cognition decline in patients with silent cerebrovascular disease (SCD) hyperintensities (WMH) vascular origin. However, evaluation is complex poor consistency. We established an intelligent algorithm to evaluate WMH pathway. Methods Patients SCD origin were enrolled. Cholinergic Pathways Hyperintensities Scale (CHIPS) was used measure impairment. a deep learning model based on convolutional neural networks...
Abstract To explore the potential target and mechanism of action Coix seed in treatment pneumonia by means network pharmacology molecular docking. construct protein interaction “component-target” diagram, GO KEGG enrichment analysis were performed, then docking was used for verification. In coix seed, 7 effective components 144 corresponding targets obtained screening with OB ≥ 30% DL 0.18% as thresholds. A total 5014 related obtained, 90 common obtained.151 nodes 251 edges read visual...
This study was designed to investigate the flavor and taste change rules of Sophora Flavescentis Radix processed using ancient classical method documented in Master Lei's Discourse on Medicinal Processing(Lei Gong Pao Zhi Lun). The pieces corresponding test samples each processing stage were first prepared based for recorded Then flavors tastes undergoing soaking rice-washed water, washing with clean steaming different time compared electronic nose tongue. results showed that preparation...
To investigate the potential molecular mechanism of combination Platycodonis Radix and Lilii Bulbus with homology medicine food in treatment pneumonia by means network pharmacology vitro verification experiment. Under condition bioavailability(OB)≥30% drug-like(DL)≥0.18, active components were screened TCMSP database; prediction targets searched from TCMSP, DrugBank other databases, obtained through GeneCards OMIM database. The common intersection drug disease targets. PPI was constructed...
The morbidity and mortality associated with vascular cognitive impairment (VCI) generally increase steeply, health systems will face increasing demand for services. present study aims to screen key genes give new insight into the mechanisms treatment of VCI based on bioinformatic approaches combined biological experiments in rats. gene expression data patients contained GSE122063 set were downloaded from Gene Expression Omnibus. We performed a weighted co-expression network analysis identify...
To examine whether probable REM sleep behavior disorder (pRBD) was associated with increased risk of developing stroke in a community-based cohort.
Objective To evaluate the efficacy of cognitive intervention in general function, memory ability and daily life patients with vascular dementia by systematic review. Methods The randomized controlled clinical trials (RCTs) comparing versus measurement were collected through databases, such as PubMed, Embase, JBI Library, Cochrane CINAHL, APA PsyCNET, CNKI Wanfang Data, from January 2000 to December 2017. The reviewers extracted data assessed quality. And then, RevMan 5.3 software was...
Objective To study the characteristics of cognitive function changes in patients with cerebellar infarction, and to clarify association between infarction function. Methods A total 106 admitted our hospital from June 2017 December 2018, 55 healthy subjects recruited at same time were chosen. National Institute Health Stroke Scale (NIHSS) was used evaluate neurological deficits, modified International Cooperative Ataxia Rating (ICARS) balance function. The differences two groups...
Abstract Background: This study aims to explore the predictive value of concomitant disease scoring for prognosis patients with acute cerebral infarction (ACI). Methods: A total 399 ACI, who met inclusion criteria, were enrolled into present study. The score was assessed within 24 hours after admission, and risk degree death analyzed. Then, goodness fit test validity analysis carried out, best survival/death cut-off determined, its ACI assessed. Results: area under receiver operating...