A5010350925- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cardiac Ischemia and Reperfusion
- COVID-19 Clinical Research Studies
- Heart Rate Variability and Autonomic Control
- Long-Term Effects of COVID-19
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Mechanical Circulatory Support Devices
- Trauma and Emergency Care Studies
- COVID-19 diagnosis using AI
- Occupational and environmental lung diseases
- Neonatal and Maternal Infections
- Cardiac Imaging and Diagnostics
- Traumatic Brain Injury Research
- Machine Learning in Healthcare
- Respiratory Support and Mechanisms
- COVID-19 and Mental Health
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
Beijing Chao-Yang Hospital
2012-2024
Capital Medical University
2012-2024
Beijing Chaoyang Emergency Medical Center
2016-2021
Yang Hospital
2019-2020
Virginia Commonwealth University
2017
Weil Institute of Critical Care Medicine
2014-2015
Foundation for the Advancement in Research in Medicine
2014-2015
ObjectiveTo describe the characteristics and outcomes of patients with severe COVID-19 in-hospital cardiac arrest (IHCA) in Wuhan, China.MethodsThe pneumonia after IHCA over a 40-day period were retrospectively evaluated. Between January 15 February 25, 2020, data for all cardiopulmonary resuscitation (CPR) attempts that occurred tertiary teaching hospital China collected according to Utstein style. The primary outcome was restoration spontaneous circulation (ROSC), secondary 30-day...
Abstract Background This study aimed to develop and validate an interpretable machine-learning model that utilizes clinical features inflammatory biomarkers predict the risk of in-hospital mortality in critically ill patients suffering from sepsis. Methods We enrolled all diagnosed with sepsis Medical Information Mart for Intensive Care IV (MIMIC-IV, v.2.0), eICU Collaborative Research (eICU-CRD 2.0), Amsterdam University Centers databases (AmsterdamUMCdb 1.0.2). LASSO regression was...
Increasing evidence has shown that mild hypothermia is neuroprotective for comatose patients resuscitated from cardiac arrest, but the mechanism of this protection not fully understood. The aim study was to determine whether prolonged whole-body inhibits mitochondrial membrane permeability (MMP) in cerebral cortex after return spontaneous circulation (ROSC). Thirty-seven inbred Chinese Wuzhishan minipigs were successfully 8 minutes untreated ventricular fibrillation (VF) and underwent...
Abstract This study aimed to identify clinical features for prognosing mortality risk using machine-learning methods in patients with coronavirus disease 2019 (COVID-19). A retrospective of the inpatients COVID-19 admitted from 15 January March 2020 Wuhan is reported. The data symptoms, comorbidity, demographic, vital sign, CT scans results and laboratory test on admission were collected. Machine-learning (Random Forest XGboost) used rank risk. Multivariate logistic regression models applied...
Mild hypothermia is the only effective treatment confirmed clinically to improve neurological outcomes for comatose patients with cardiac arrest. However, underlying mechanism not fully elucidated. In this study, our aim was determine effect of mild on mitochondrial oxidative stress in cerebral cortex. We intravascularly induced (33°C), maintained temperature 12 h, and actively rewarmed inbred Chinese Wuzhishan minipigs successfully resuscitated after 8 min untreated ventricular...
Clinical manifestation and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) were unclear in Wuhan, China.We retrospectively analyzed clinical characteristics nonpregnant COVID-19 aged from 20 to 40, admitted between January 15 March 15, 2020 at Union Hospital, symptoms compared the historic data previously reported for H1N1.Among 64 patients, 34 (53.13%) pregnant, higher proportion exposure history (29.41% vs 6.67%) more pulmonary infiltration on computed...
Complement activation has been implicated in ischemia/reperfusion injury. This study aimed to determine whether mild hypothermia (HT) inhibits systemic and cerebral complement after resuscitation from cardiac arrest. Sixteen minipigs resuscitated 8 minutes of untreated ventricular fibrillation were randomized into two groups: HT group (n=8), treated with (33°C) for 12 hours; normothermia similarly as except cooling. Blood samples collected at baseline 0.5, 6, 12, 24 hours return spontaneous...
This study aimed to explore the characteristics of abnormal regional resting-state functional magnetic resonance imaging (rs-fMRI) activity in comatose patients early period after cardiac arrest (CA), and investigate their relationships with neurological outcomes. We also explored correlations between jugular venous oxygen saturation (SjvO2) rs-fMRI resuscitated patients. examined relationship amplitude N20-baseline within intracranial conduction pathway somatosensory evoked potentials...
The aim of this study was to evaluate the effect mild hypothermia on coagulation-fibrinolysis system and physiological anticoagulants after cardiopulmonary resuscitation (CPR). A total 20 male Wuzhishan miniature pigs underwent 8 min untreated ventricular fibrillation CPR. Of these, 16 were successfully resuscitated randomized into group (MH, n = 8) or control normothermia (CN, 8). Mild (33°C) induced intravascularly, temperature maintained for 12 h before actively rewarmed. CN received...
This study aimed to investigate the possible relationship between two biomarkers presepsin and procalcitonin (PCT) monocyte immune function, explore their combination in mortality prediction early stage of sepsis. A total 198 patients with bacterial infection diagnosed sepsis 40 healthy control subjects were included. Blood samples collected on admission within 24 h. Plasma concentrations PCT measured. Expression surface CD14, programmed cell death receptor ligand-1 (PD-L1) human leucocyte...
Studies have demonstrated that vagus nerve stimulation (VNS) reduces ischemia/reperfusion injury. In this study, we investigated the protective effects of VNS in a rat model cardiopulmonary resuscitation (CPR). We further whether beneficial were dependent on alpha 7 nicotinic acetylcholine receptor (α7nAChR). Forty animals randomized into four groups and all underwent CPR (n = 10 each): alone (control); during CPR; α7nAChR antagonist methyllycaconitine citrate (MLA) with VNS; agonist 3-(2,...
ABSTRACT Introduction: Long-term use of antibiotics for septic patients leads to bacterial resistance, increased mortality, and hospital stay. In this study, we investigated an emerging biomarker presepsin-guided strategy, which can be used evaluate the shortening antibiotic treatment in with sepsis without risking a worse outcome. Methods: multicenter prospective cohort trial, were assigned presepsin or control groups. group, ceased based on predefined cut-off ranges concentrations. The...
In sepsis, the relationship between lymphocyte counts and patient outcomes is complex. Lymphocytopenia lymphocytosis significantly influence survival, illustrating dual functionality of lymphocytes in responding to infections. This study investigates this complex interaction, focusing on how variations correlate with all-cause hospital mortality among sepsis patients. retrospective cohort analyzed data from two extensive critical care databases: Medical Information Mart for Intensive Care IV...
Objective This investigation evaluated the real-time point-of-care testing (RT-POCT) of neutrophil gelatinase-associated lipocalin (NGAL) for detecting acute kidney injury (AKI) and prognosis critically ill patients. Methods A total 249 patients in emergency department (ED), who were diagnosed with decompensated heart failure, sepsis or diabetic ketoacidosis enrolled this study. All followed up 28 days to death mortalities recorded. Serum creatinine (sCr) NGAL measured. Results 40.6%...
Background: Hypothermia attenuates microglial activation and exerts a potential neuroprotective effect against cerebral ischemic-reperfusion (I/R) injury. However, the underlying mechanism remains to be elucidated. In this in vitro study, model of oxygen-glucose deprivation, followed by recovery (OGD/R), was used investigate whether hypothermia anti-inflammatory anti-apoptosis properties via enhanced ubiquitination down-regulation voltage-dependent anion channel 3 (VDAC3) expression....
Rapid changes in glucocorticoid (GC) levels and adrenal insufficiency are related to the development of post-cardiac arrest (CA) syndrome. However, GC receptor (GR) expression have not been studied. Hence, this study aimed investigate association early GR prognosis immune response patients who experienced CA.
Background. In view of the global efforts to develop effective treatments for current worldwide coronavirus 2019 (COVID-19) pandemic, Qingfei Paidu decoction (QPD), a novel traditional Chinese medicine (TCM) prescription, was formulated as an optimized combination constituents classic prescriptions used treat numerous febrile and respiratory-related diseases. This prescription has been patients with COVID-19 pneumonia in Wuhan, China. Hypothesis/Purpose. We hypothesized that QPD would have...
Correction to: Journal of Cerebral Blood Flow & Metabolism (2013) 33, 928–934; doi: 10.1038/jcbfm.2013.33 ; published online 13 March 2013 A fund grant number was incorrectly omitted from the Acknowledgements. The following sentence should be read with Funding Statement: ‘This work supported by Liaoning Province Nature Science Foundation (Grant No. 2013023020).’
This study aimed to compare the changes in sublingual and conjunctival microcirculation occurring with cerebral cortex during mild hypothermia a rat model of cardiac arrest.Twenty-four rats were randomized into (M) or normothermia (C) groups. Ventricular fibrillation was electrically induced left untreated for 8 minutes, followed by minutes cardiopulmonary resuscitation. The core temperature group M reduced 33 ± 0.5°C at 13 after restoration spontaneous circulation maintained hours. In C, 37...