A5100440506- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced SAR Imaging Techniques
- Mechanical Circulatory Support Devices
- Thermal Regulation in Medicine
- Cardiac Ischemia and Reperfusion
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Trauma and Emergency Care Studies
- Immune Response and Inflammation
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Emergency and Acute Care Studies
- Anesthesia and Neurotoxicity Research
- EEG and Brain-Computer Interfaces
- Gallbladder and Bile Duct Disorders
- Cardiac electrophysiology and arrhythmias
- Acute Myocardial Infarction Research
- Hemodynamic Monitoring and Therapy
- Neonatal and Maternal Infections
- Radiation Therapy and Dosimetry
- Heart Failure Treatment and Management
- Radioactivity and Radon Measurements
Capital Medical University
2015-2024
Ningxia Medical University
2024
Beihang University
2007-2024
Beijing Friendship Hospital
2018-2024
Health Canada
2016-2024
Suzhou University of Science and Technology
2024
Northeast Forestry University
2024
Shenyang University of Technology
2013-2024
Hubei Engineering University
2018-2024
Chifeng University
2019-2023
Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of cancer stem cells. However, our knowledge expression and activity ALDH1 in common epithelial cancers their corresponding normal tissues is still largely absent. Therefore, we characterized 24 types a large collection tumor specimens (six types, n = 792) by immunohistochemical staining. Using ALDEFUOR assay, was also examined 16 primary 43 established cell lines. In addition, an ovarian transgenic mouse...
Abstract: Conventional chemotherapy of ovarian cancer often fails because initiation drug resistance and/or side effects and trace untouched remaining cancerous cells. This highlights an urgent need for advanced targeted therapies effective remediation the disease using a cytotoxic agent with immunomodulatory effects, such as shikonin (SHK). Based on preliminary experiments, we found SHK to be profoundly toxic in epithelial cells (OVCAR-5 ID8 cells) well normal IOSE-398 cells, endothelial...
Increasing evidence has shown that mild hypothermia is neuroprotective for comatose patients resuscitated from cardiac arrest, but the mechanism of this protection not fully understood. The aim study was to determine whether prolonged whole-body inhibits mitochondrial membrane permeability (MMP) in cerebral cortex after return spontaneous circulation (ROSC). Thirty-seven inbred Chinese Wuzhishan minipigs were successfully 8 minutes untreated ventricular fibrillation (VF) and underwent...
The Partner Agencies of the International Space Station (ISS) maintain separate career exposure limits and shared Flight Rules that control ionising radiation exposures crewmembers can experience due to ambient environments throughout their space missions. In low Earth orbit as well further out in space, energetic ions referred galactic cosmic (GCR) easily penetrate spacecraft contents consequently are always present at dose rates. Protons electrons trapped Earth's geomagnetic field...
Recent experimental and clinical studies have indicated that the β-adrenergic effect of epinephrine significantly increases severity post resuscitation myocardial dysfunction. The aim study was to investigate whether short-acting β₁-selective adrenergic blocking agent, esmolol, would attenuate dysfunction in a porcine model cardiac arrest.After 8 min untreated ventricular fibrillation 2 basic life support, 24 pigs were randomized three groups (n = per group), which received central venous...
Mild hypothermia improves survival and neurological recovery after cardiac arrest (CA) cardiopulmonary resuscitation (CPR). However, the mechanism underlying this phenomenon is not fully elucidated. The aim of study was to determine whether mild alleviates early blood-brain barrier (BBB) disruption. We investigated effects on neurologic outcome, rate, brain water content, BBB permeability changes in tight junctions (TJs) adherens (AJs) CA CPR. Pigs were subjected 8 min untreated ventricular...
Objectives: Postresuscitation care bundle treatment after return of spontaneous circulation in patients experiencing in-hospital cardiac arrest can improve patients’ survival and quality life. The aim the study was to evaluate efficacy safety combined therapy Shenfu injection postresuscitation these patients. Design: Prospective, randomized, controlled clinical study. Setting: Fifty hospitals China. Patients: Adult had experienced between 2012 2015. Interventions: Based on standardized...
Biological dosimetry enables individual dose reconstruction in the case of unclear or inconsistent radiation exposure situations, especially when a direct measurement ionizing is not no longer possible. To be prepared for large-scale radiological incidents, networking between well-trained laboratories has been identified as useful approach provision fast and trustworthy assessments needed such circumstances. this end, various biodosimetry worldwide have joined forces set up regional and/or...
BACKGROUND:The aim of this study is to investigate the diagnostic and prognostic value neutrophil CD64 (nCD64) as a novel biomarker in sepsis patients. METHODS:One hundred fifty-one adult patients diagnosed with 20 age-matched healthy controls were enrolled study.Patients further subdivided into group septic shock group.nCD64 expression, serum procalcitonin (PCT) level, C-reactive protein (CRP) white blood cell (WBC) count obtained for each patient, Sequential Organ Failure Assessment (SOFA)...
Abstract While regulatory T cells (Tregs) constitutively express programmed cell death‐1 ( PD ‐1), the role of ‐1 expression in Tregs patients with sepsis remains unclear. Thus, we determined from peripheral blood severe and septic shock. Seventy‐eight 40 shock, as well 21 healthy subjects, were enrolled this study. The percentage + Tregs, absolute Treg counts, compared between these three groups. counts also survivors non‐survivors sepsis. increased to controls. Conversely, significantly...
Objective The purpose of this study was to assess the trends in outcomes out-of-hospital cardiac arrest (OHCA) Beijing over 5 years. Design Cross-sectional study. Methods Adult patients with OHCA all aetiologies who were treated by emergency medical service (EMS) between January 2013 and December 2017 analysed. Data collected using Utstein Style. Cases followed up for 1 year. Descriptive statistics used characterise sample logistic regression performed. Results Overall, 5016 underwent...
Preclinical and clinical studies have demonstrated the anticancer activity of PD-0332991, a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, in treatment various types cancer retinoblastoma protein (RB)-dependent manner. However, it remains unclear whether CDK4, CDK6 or both are required for RB phosphorylation colorectal carcinoma thus PD-0332991 can be used to target this CDK-RB axis therapy. The aim study was determine phosphorylated proteins were overexpressed tissues as compared...
Obesity is associated with an increased risk of diabetes mellitus, hypertension, and coronary artery disease; however, the relation between body mass index (BMI) all-cause mortality controversial. We prospectively examined relationship BMI in 123,384 Chinese men women who participated Kailuan health examination study from 2006 to 2007 2008 2009. Cases included 6218 deaths (5770 448 women) that occurred during a mean follow-up period 7.39 years. Relative was adjusted for factors such as age,...
HFZIF-8/GA is prepared via a simple stirring method for loading GA. After HA modification, HFZIF-8/GA@HA used the targeted delivery of Fe ions and GA, thereby achieving in situ synthesis an Fe-GA complex thermal catalytic therapy.