A5100357949- Immunotherapy and Immune Responses
- Microtubule and mitosis dynamics
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Cancer and Skin Lesions
- DNA Repair Mechanisms
- Renal cell carcinoma treatment
- Medical Research and Treatments
- Immune cells in cancer
- Breast Lesions and Carcinomas
- Musculoskeletal pain and rehabilitation
- Breast Cancer Treatment Studies
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Thermal Regulation in Medicine
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Cardiac Arrest and Resuscitation
- Hydropower, Displacement, Environmental Impact
- Vascular Tumors and Angiosarcomas
Anhui Medical University
2023-2024
Zhengzhou University
2024
The Affiliated Hospital to Changchun University of Chinese Medicine
2022-2023
Tohoku University
2023
Weifang Medical University
2023
Jinan University
2023
Xiangnan University
2023
First Hospital of China Medical University
2018-2022
China Medical University
2017-2022
St. Jude Children's Research Hospital
2022
Background. A body-weight-based dose of tacrolimus often results in marked individual diversity blood drug concentration. Tacrolimus is a substrate for cytochrome P450 (CYP) 3A5 and p-glycoprotein encoded by CYP3A5 MDR1 (ABCB1), respectively, having multiple single nucleotide polymorphisms. In this study, we genotyped A6986G, G2677(A/T), C3435T polymorphisms investigated the association between these pharmacokinetics renal transplant recipients. Methods. Thirty consecutive recipients were...
Expression of PD-L1 has been estimated to predict the therapeutic potential inhibition in solid tumors. Recent studies have demonstrated that plays a critical role regulatory T-cell (Treg) development and functional maintenance. Although increases FOXP3(+)Treg infiltration expression revealed several malignancies, their correlation human breast tumors is as yet unclear.Whole-tissue sections from 501 patients with cancer were examined for FOXP3 by immunohistochemistry. Correlation between...
Tamoxifen is widely used to treat hormone-dependent breast cancer, but its therapeutic benefit limited by the development of drug resistance. Here, we investigated role estrogen G-protein coupled receptor 30 (GPR30) on resistance in cancer.Primary tumors (PTs) cancer and corresponding metastases (MTs) were evaluate expression GPR30 epidermal growth factor (EGFR) immunohistochemically. Tamoxifen-resistant (TAM-R) subclones derived from parent MCF-7 cells investigate tamoxifen resistance,...
Aims: Tumor associated macrophages (TAMs) play a critical role in the initiation and progression of breast cancer. However, their prognostic significance molecular subtype basal-like cancer (BLBC) is poorly understood. The aim this study was to investigate extent patterns TAMs BLBC associations with clinicopathological features patient survival. Methods Results: We evaluated 200 cases by immunohistochemistry using M2 macrophage marker CD163 pan-macrophage CD68 tumor nest stroma, assessed...
Purpose: Polo-like kinase 4(PLK4) is an important evolutionarily regulator involved in centrosome duplication.We here investigated the expression of PLK4 mRNA and breast cancer, evaluated its predictive value for response to taxane-based neoadjuvant chemotherapy.Method: The was measured cancer tissues corresponding normal from 30 patients by quantitative real-time polymerase chain reaction (PCR).The association with clinicopathological parameters prognostic significance 154 cases invasive...
Abstract CCND1 mRNA is alternatively spliced to produce 2 transcripts, and the splicing pattern may be modulated by a frequent A 870 G single‐nucleotide polymorphism within conserved splice donor site of exon 4. Several studies have suggested significant association between genotype onset or progression various cancers. To investigate correlation with genetic susceptibility PCa its disease status, we examined in 214 cases PCa, 234 BPH 254 male controls. The allele was more frequently...
Mild hypothermia improves survival and neurological recovery after cardiac arrest (CA) cardiopulmonary resuscitation (CPR). However, the mechanism underlying this phenomenon is not fully elucidated. The aim of study was to determine whether mild alleviates early blood-brain barrier (BBB) disruption. We investigated effects on neurologic outcome, rate, brain water content, BBB permeability changes in tight junctions (TJs) adherens (AJs) CA CPR. Pigs were subjected 8 min untreated ventricular...
BACKGROUND:Cancer immunotherapy is the use of immune system to treat cancer. After years research, there have been a significant number publications in this field. We analyzed literature and performed hotspot analysis identify important areas future scientific research. MATERIAL AND METHODS:Articles (2945) related cancer published past 3 were selected as research sample. BICOMB software was then used retrieve high-frequency words construct text/co-word matrix. Next, gCLUTO analyze matrix by...
Apoptosis plays a critical role in the diabetic cardiomyopathy, and endoplasmic reticulum stress (ERS) is one of intrinsic apoptosis pathways. Previous studies have shown that becomes swollen dilated myocardium, ERS involved heart failure kidney. This study aimed to demonstrate whether induced myocardium streptozotocin (STZ)-induced rats. We established type 1 rat model, used echocardiographic evaluation, hematoxylin–eosin staining, terminal deoxynucleotidyl transferase-mediated DNA nick-end...
Background Atherosclerosis is a chronic inflammatory disease mediated by immune cells. Th22 cells are CD4+ T that secret IL-22 but not IL-17 or IFN-γ and implicated in the pathogenesis of disease. The roles pathophysiologic procedures acute coronary syndrome (ACS) remain unclear. purpose this study to investigate profile Th22, Th17 Th17/Th1 ACS patients, including unstable angina (UA) myocardial infarction (AMI) patients. Design Methods In study, 26 AMI 16 UA stable (SA) patients healthy...
Abstract Little is known about the incidence, clinical characteristics and prognostic factors in HIV associated lymphoma as these are less common than HIV‐negative China. Currently, there no standard guidelines for treatment of patients. Therefore, we performed a study to analyse outcomes newly diagnosed HIV‐associated aggressive B‐cell non‐Hodgkin's (NHL) patients Chongqing University Cancer Hospital (CUCH). Totally 86 NHL CUCH, southwest China, from July 2008 August 2021, were analysed. In...
The significance of PLK1 (polo-like kinase 1) has become increasingly essential as both a biomarker and target for cancer treatment. Here, we aimed to determine the downstream genes their effects on carcinogenesis progression bladder cancer. Specific siRNA was utilized silence gene expression. cell proliferation, invasion migration cells by MTT assay, BrdU assay transwell assay. differential expression were identified using Affymetrix HTA2.0 Array. KEGG, GO STRING analysis used analyze...
Abstract Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA frequently expressed esophageal correlated with poor prognosis. Consequently, MAGE-A11 potential target. In this study, we evaluated expression found it was downregulated several tumor cell lines, which restricted the effect of...
Hematopoietic stem and progenitor cells (HSPCs) could be differentiated into mature myeloid lymphoid cells, maintaining the requirements of immune cells. Atherosclerosis ulcerative colitis (UC) drive HSPC homeostasis destruction, which triggers expansive proliferation Ly6Chi monocyte production, contributing to aggravated inflammation. Vitisin A belongs anthocyanin derivatives with excellent stability bioactivity in vitro. However, there is no report about anti-inflammation via reprogramming...
Based on a large Online Survey of Micro-and-small Enterprises (OSOME) conducted in March 2021 micro-and-small enterprises and self-employed businesses (MSEs) operating the Alipay platform, this paper examines operational status, challenges, responses, confidence MSEs after exposure to COVID-19 pandemic for over year China. The status has significantly improved despite cash flow constraints. Rising costs weak demand were two key challenges. In response shock, higher percentage newly...
To explore the efficacy and safety of medical thoracoscopic bulla volume reduction for treatment chronic obstructive pulmonary disease (COPD) combined with giant emphysematous bullae (GEB).
Chromosomal aneuploidy has been associated with aging. However, whether and how chromosomal instability (CIN), a condition frequently seen in cancer cells which chromosome missegregation occurs at high rate, is aging not fully understood. Here we found that primary fibroblasts isolated from aged mice exhibit an increased level of micronucleation compared young mice, concomitant rate aneuploid cells, suggesting the emergence CIN. Reactive oxygen species were was accompanied mitochondrial...
Cancer stem cells (CSCs) give rise to a diverse variety of differentiated cells, which comprise the bulk tumor microenvironment (TME). However, exact multi-directional differentiation potential CSCs has not been fully clarified. This study was designed explore whether differentiate into cellular components TME promote growth lung carcinoma.The present CD133+, CD2+, and CD133+CD2+ in both clinical adenocarcinoma tissue non-small cell carcinoma (NSCLC) lines were monitored using polymerase...