A5067954504- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Monoclonal and Polyclonal Antibodies Research
- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Drug Solubulity and Delivery Systems
- Glycosylation and Glycoproteins Research
- Electrospun Nanofibers in Biomedical Applications
- Dendrimers and Hyperbranched Polymers
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Nanoparticles: synthesis and applications
- MicroRNA in disease regulation
- Barrier Structure and Function Studies
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- Inhalation and Respiratory Drug Delivery
Nova Southeastern University
2022-2025
Tabriz University of Medical Sciences
2015-2024
University of Pennsylvania
2011-2022
Cancer Research Center
2012-2022
University of Tabriz
2009-2017
Zabol University of Medical Sciences
2013
National Engineering Research Center for Nanotechnology
2011-2012
Cardiff University
2003-2008
Iron-oxide nanoparticles (IONs) with biocompatible coatings are the only nanostructural materials which have been approved by FDA for clinical use. Common such as hydrocarbons, polymers, and silica profound influences on critical characteristics of IONs. Recently, amino acids were introduced a novel coating. In present study, effects IONs synthesis evaluated. Magnetite L-arginine L-lysine synthesised coprecipitation reaction in aqueous solvent their compared naked magnetite nanoparticles....
To investigate the anti-inflammatory impacts of piroxicam nanosuspension, in current investigation, piroxicam:Eudragit RS100 nanoformulations were used to control inflammatory symptoms rabbits with endotoxin-induced uveitis (EIU). The nanoparticles was formulated using solvent evaporation/extraction technique. morphological and physicochemical characteristics studied particle size analysis, X-ray crystallography, differential scanning calorimetry (DSC), Fourier transform infrared...
Rivastigmine hydrogen tartrate (RHT), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for treatment Alzheimer's disease. However, bioavailability RHT from conventional pharmaceutical forms is low because presence blood brain barrier. The main aim present study was to prepare positively charged Eudragit RL 100 nanoparticles model scaffold providing sustained release profile RHT. formulations were evaluated in terms particle size, zeta...
A growing interest in apoptosis, programmed cell death, the last years is observed and leads to better understanding of molecular mechanisms during cell-cell signaling, cell-environment interaction screening drugs. This turn results emerging new assays development more accurate kits for fast early detection apoptosis. However, their sensitivity reliability have often been scrutinized. Here we introduce a rapid improved method DNA ladder apoptosis assay evaluating mammalian cells.NIH-3T3 line...
Purpose: Doxorubicin is administrated as a single agent in first-line therapy of breast cancer to induce apoptosis tumor cells. Bax, Bcl-xL, Caspase-8 and 9 proteins are involved induction apoptosis. The present study describes Bcl-xL gene expression protein levels MCF-7 cells incubated with doxorubicin at different doses an incubation times. Methods: cytotoxic effects were studied using MTT assay. treated three concentrations (0.1, 0.5, 1 μM) for 24, 48 72 hours then Bax genes elucidated by...
A gold electrode decorated with nanoparticles, CdSe quantum dots and anti-CA-125 antibody (MPA|AuNP@SiO<sub>2</sub>|QD|mAb immunosensor) sensitively specifically detects the CA-125 oncomarker.
Non-small cell lung cancer (NSCLC) patients with sensitizing mutations in the exons 18-21 of epithelial growth factor receptor (EGFR) gene show increased kinase activity EGFR. Hence, tyrosine inhibitors (TKIs) such as erlotinib (ETB) have commonly been used second line therapeutic option for treatment metastatic NSCLC. While ETB is available an oral dosage form, local delivery this TKI to diseased cells may ameliorate its impacts. In current study, we report on development ETB-loaded solid...
Aim: The overexpression of miRNA-21 correlates with the cisplatin (CIS) resistance in ovarian cancers. Methods: AS1411 antinucleolin aptamer-decorated PEGylated poly(lactic-co-glycolic acid) nanoparticles containing CIS (Ap–CIS–NPs) and anti-miR-21 (Ap-anti-miR-21-NPs) were prepared, physicochemically investigated their cancer-targeting ability was confirmed. CIS-resistant A2780 cells (A2780 R) infected using Ap-anti-miR-21-NPs to decrease drug sensitize CIS. Afterward, miR-21-inhibited...
The goal of this study was to establish paclitaxel resistant MCF-7 cells, as in vitro model, identify the molecular mechanisms leading acquired chemoresistance breast cancer cells. Resistant cells were developed by stepwise increasing exposure paclitaxel. Gene expression levels Bax and Bcl-2 along with protein caspase-8 caspase-9 evaluated two cell lines (MCF-7/Pac64 MCF-7/Pac5 nM). Morphological modifications resistance examined light microscopy fluorescence activated sorting (FACS). As an...