Rivastigmine hydrogen tartrate (RHT), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for treatment Alzheimer's disease. However, bioavailability RHT from conventional pharmaceutical forms is low because presence blood brain barrier. The main aim present study was to prepare positively charged Eudragit RL 100 nanoparticles model scaffold providing sustained release profile RHT. formulations were evaluated in terms particle size, zeta...

Oxytetracycline is an antibiotic for the treatment of infections caused by Gram-positive and Gram-negative microorganisms. Among novel formulations applied damaged skin, hydrogels have shown to be superior as they can provide a moist environment wound. The purpose this study was prepare evaluate oxytetracycline consisted polyvinyl alcohol (PVA) chitosan polymers. A design based on 4 factors 3 levels used preparation evaluation formed freeze-thaw (F-T) cycle using PVA matrix-based wound...

The aim of this study was to evaluate microencapsulated controlled release preparations tolmetin sodium using ethylcellulose as a retardant material. Microspheres were prepared by water-in-oil-in-oil (W/O(1)/O(2)) double-emulsion solvent diffusion method, different ratios sodium. Span 80 used the droplet stabilizer and n-hexane added harden microspheres. microspheres characterized for their micromeritic properties, drug content, loading efficiency, production yield, particle size. Fourier...

Purpose: Rivastigmine hydrogen tartrate (RHT) is commonly used for the treatment of mild to moderate Alzheimer's disease (AD). The aim this work was formulate in-situ pluronic F-127 (PF-127) hydrogels containing Eudragit RL-100 (EU-RL) nanoparticles (NPs) in order improve therapeutic efficacy RHT through nasal route. Methods: NPs were prepared using different polymer drug ratios and evaluated their physicochemical characteristics, cellular uptake vitro cytotoxicity against lung...

Background Bortezomib (BTZ) as an anticancer drug has been used through the injection pathway.Research design and methods Two types of Cyclodextrin nanosponges (CDNSs) were synthesized studied by DLS, TEM, FTIR, DSC instruments for BTZ delivery. Both carriers analyzed loading efficiencies in-vitro release. Cell studies intestinal permeability selected CDNS determined using MTT SPIP method, respectively.Results CDNSs, encapsulated in their nano-porous structure, but better was shown 1:4. FTIR...

The dawn of the state-of-the-art methods drug/gene delivery, nano-based delivery systems for pharmaceutically active agents into target sites in body have been developed. Among these, a concerted effort has directed towards development biodegradable/biocompatible nanomaterials with high potential benefits passive/active targeting and reduced undesirable side effects. Since polysaccharides offer large number available reactive groups, specific could be obtained by surface coating...

The aim of this study was to investigate the capability polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles in improving anti-inflammatory effects dexamethasone (DEX). A film hydration method used for preparation DEX-loaded PCL-PEG-PCL micelles. In vitro cytotoxicity obtained investigated on L929 cells. Cellular uptake studied by using flow cytometry and fluorescence microscopy. Anterior uveitis induced a group rabbits intravitreal injection endotoxin from Salmonella...

Selegiline hydrochloride (SL) is chosen as an adjunct for the control of clinical signs Parkinsonian patients. The aim present work to develop and optimize thermosensitive gels using Pluronic (F-127) enhancing transport SL into brain through nasal route. were prepared a cold method Box-Behnken experimental design methodology. Drug (SL), gelling agent (F-127), emulsifier (Propylene glycol, PG) selected independent variables, while gelation temperature, gel strength, pH, content, erosion...

The aim of the present research was to investigate feasibility developing polylactide–polycaprolactone–polyethylene glycol–polycaprolactone–polylactide (PLA–PCL–PEG–PCL–PLA) based micelles improve ocular permeability dexamethasone (DEX). PLA–PCL–PEG–PCL–PLA copolymers were synthesized by a ring-opening polymerization method. DEX loaded into developed copolymers. DEX-loaded characterized using transmission electron microscopy (TEM) and dynamic light scattering (DLS) methods. Cytotoxicity...

Microencapsulation is a useful method to prolong drug release from dosage forms and reduce its adverse effect (1) among various available methods. The microencapsulation of hydrophilic active ingredients requires the use polar dispersing phase such as mineral oil. Acetone/paraffin systems are conventionally used.The current study aimed investigate two different techniques comparatively, water in oil (w/o/o) (o/o), for theophylline (TH) loaded ethylcellulose (EC), cellulose acetate butyrate...

Targeted drug delivery to colon would ensure direct treatment at the disease site, decrease in dose administration and reduction side effects improved utilization.The purpose of this research was gastric piroxicam by formulating microspheres alginate algino-pectinate beads drug.Ionotropic gelation used entrap into mucoadhesive as a potential carrier for oral piroxicam. Microparticles with different polymers ratio were prepared characterized encapsulation efficiency, particle size, DSC...

Background: Sumatriptan succinate is a 5-HT1 receptor agonist which used in the treatment of migraine. It shows low bioavailability (15%) due to high hepatic first pass metabolism. The present work intended formulate mucoadhesive sublingual films sumatriptan combined with metoclopramide and sumatriptan alone objective of improving therapeutic efficacy, patient compliance, and bioavailability. Methods: were formulated by solvent casting technique using mucoadhesive polymer...

Background: Alzheimer's disease (AD) is an age-related and irreversible neurological disorder. The low efficacy of current therapeutic strategies related to both poor drug potency the presence various obstacles in delivery routes, such as blood-brain barrier (BBB) that limits uptake most drugs by brain. Rivastigmine hydrogen tartrate (RHT) used mild moderate forms AD therapy. Objectives: present study described use Poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs), effective vehicles,...