A5039676506- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Ocular Surface and Contact Lens
- Heat Transfer and Boiling Studies
- Advancements in Transdermal Drug Delivery
- Nanofluid Flow and Heat Transfer
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Heat Transfer and Optimization
- Heat Transfer Mechanisms
Tabriz University of Medical Sciences
2015-2017
Isfahan University of Technology
2009
Background: Sumatriptan succinate is a 5-HT1 receptor agonist which used in the treatment of migraine. It shows low bioavailability (15%) due to high hepatic first pass metabolism. The present work intended formulate mucoadhesive sublingual films sumatriptan combined with metoclopramide and sumatriptan alone objective of improving therapeutic efficacy, patient compliance, and bioavailability. Methods: were formulated by solvent casting technique using mucoadhesive polymer...
Purpose: The objective of this study was to develop, characterize, and comparatively investigate the ketotifen fumarate (KF) nanosuspensions (NSS) enhance permeability KF. Methods: In present work, NSP NSE were prepared by double-emulsion solvent evaporation/nanoprecipitation methods with poly (D,Llactide-co-glycolide) Eudragit RL100 polymers, respectively. loading efficiency, particle size, polydispersity index different NSs evaluated scanning electron microscopy (SEM), X-ray diffraction,...
Ergotamine tartrate (ET), a serotonin 5-HT1 receptor agonist, is an anti-migraine drug. Due to high first-pass metabolism, ET shows very low bioavailability in oral administrations (<1%). Caffeine (CA) increases the rate and extent of water solubility ET. The present study intended investigate possibility developing fast dissolving thin films for drug dissolution cavity, thus bypassing first pass metabolism providing quick onset action Methods: (ET CA) were prepared according solvent casting...
Sumatriptan succinate (Sum) is a Serotonin 5- HT1 receptor agonist, used in the treatment of migraine. It absorbed rapidly but incompletely when taken orally and underwent first - pass metabolism, resulting low bioavailability about 15%. The aim was to design mucoadhesive buccal discs sublingual films Sum metoclopramide (Met) combined improve their bioavailability.In current study, microparticles were prepared by emulsion solvent diffusion (ESD) casting methods, respectively....