A5036503576- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Electrochemical sensors and biosensors
- Quantum Dots Synthesis And Properties
- Plant tissue culture and regeneration
- Electrochemical Analysis and Applications
- Analytical chemistry methods development
- Photochemistry and Electron Transfer Studies
- Nanoparticle-Based Drug Delivery
- Advanced Biosensing Techniques and Applications
- Graphene and Nanomaterials Applications
- bioluminescence and chemiluminescence research
- Free Radicals and Antioxidants
- Nanoparticles: synthesis and applications
- Analytical Chemistry and Sensors
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- Gold and Silver Nanoparticles Synthesis and Applications
- Adenosine and Purinergic Signaling
- SARS-CoV-2 detection and testing
- Tryptophan and brain disorders
- Conducting polymers and applications
- Supramolecular Self-Assembly in Materials
- Microbial Fuel Cells and Bioremediation
- Carbon and Quantum Dots Applications
Ardabil University of Medical Sciences
2016-2024
Tabriz University of Medical Sciences
2012-2017
University of Tabriz
2014-2017
A gold electrode decorated with nanoparticles, CdSe quantum dots and anti-CA-125 antibody (MPA|AuNP@SiO<sub>2</sub>|QD|mAb immunosensor) sensitively specifically detects the CA-125 oncomarker.
Targeted delivery of anticancer chemotherapeutics such as mitoxantrone (MTX) can significantly intensify their cytotoxic effects selectively in solid tumors breast cancer. In the current study, folic acid (FA)-armed and MTX-conjugated magnetic nanoparticles (MNPs) were engineered for targeted eradication folate receptor (FR)-positive cancerous cells. Polyethylene glycol (PEG), FA MTX covalently conjugated onto MNPs to engineer PEGylated FA-MTX-MNPs. The internalization studies performed...
Development of biocompatible antioxidant nanoparticles for xenobiotic-induced liver disease treatment by oral or parenteral administration is great interest in medicine. In the current study, we demonstrate protective effects coenzyme Q10 (CoQ10-NPs) on hepatotoxicity induced dichlorvos (DDVP) as an organophosphate. Although CoQ10 efficient antioxidant, its poor bioavailability has limited applications this useful agent. First, CoQ10-NPs were prepared then characterized using dynamic light...
Nanoscaled quantum dots (QDs), with unique optical properties have been used for the development of theranostics. Here, InP/ZnS QDs were synthesised and functionalised folate (QD-FA), D-glucosamine (QD-GA) or both (QD-FA-GA). The bi-functionalised further conjugated doxorubicin (QD-FA-GA-DOX). Optimum Indium to fatty acid (In:MA) ratio was 1:3.5. Transmission electron microscopy (TEM) micrographs revealed spherical morphology (11 nm). Energy-dispersive spectroscopy (EDS) spectrum confirmed...
Methotrexate (MTX), a folic acid derivative, is potent anticancer used for treatment of different malignancies, but possible initiation drug resistance to MTX by cancer cells has limited its applications. Nanoconjugates (NCs) quantum dots (QDs) may favour the cellular uptake via folate receptors (FRs)-mediated endocytosis that circumvents efflux functions cells. We synthesised MTX-conjugated l-cysteine capped CdSe QDs (MTX-QD nanoconjugates) and evaluated their internalisation cytotoxicity...
Electrochemical impedance spectroscopy (EIS) is a simple and highly sensitive technique that can be used for evaluation of the aptamer-target interaction even in label-free approach.To pursue effectiveness EIS, current study, folding properties specific aptamer methamphetamine (METH) (i.e., aptaMETH) were evaluated presence METH amphetamine (Amph). Folded unfolded aptaMETH was mounted on gold electrode surface electron charge transfer measured by EIS.The Ret methamphetamine-aptaMETH...
The detection of <sc>l</sc>-tryptophan (Trp) in the extracellular matrix (ECM) solid tumors is important, particularly metastatic tumors, which catabolize Trp to kynurenine escape from host immune system-mediated recognition.
Hazelnut is one of the most important nut plants recently suggested as a sustainable source for paclitaxel. In present study, effect concentration and combination PGRs, different basal medium ultrasonic waves on callus induction growth, physiological characteristics, taxol baccatin III production in hazelnut cultures were investigated. The results indicated that combining 2,4-D (2 mg/L) Kin (0.2 with sonication explants 1 min provides an optimized condition growth. exhibited biochemical...
Galega officinalis L. is an herbaceous legume used to treat symptoms associated with hyperglycemia or diabetes mellitus because of its dominant alkaloid, galegine. In this study, we induced hairy roots in plant using Rhizobium rhizogenes strain A4, and investigated the effect type, concentration, duration elicitor application on galegine content some phytochemical characteristics roots. Hence, best growing root line terms growth rate was selected subcultured for treatment elicitors. Then, at...
Quantum dots (QDs), as a new class of fluorescent tags, have been widely used for biomedical applications. Despite their various advantages, QDs do not efficiently enter cells on own, and aggregation often occurs following internalization. In the present study, we designed three QD–cell-penetrating peptide (CPP) complexes to increase uptake QD into cells. The results demonstrated that R9 R5W3R4 form relatively stable noncovalent with QDs, considerably increasing rate efficiency by A549 These...