A5058589108- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Neuroendocrine regulation and behavior
- Cancer Research and Treatments
- Circular RNAs in diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer Cells and Metastasis
- Graphene and Nanomaterials Applications
- Atrial Fibrillation Management and Outcomes
- Characterization and Applications of Magnetic Nanoparticles
- Nitric Oxide and Endothelin Effects
- Animal Nutrition and Physiology
- Anesthesia and Neurotoxicity Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Cardiac Arrhythmias and Treatments
- Mycotoxins in Agriculture and Food
- Immunotherapy and Immune Responses
- Neuroscience of respiration and sleep
- Diet and metabolism studies
Tehran University of Medical Sciences
2015-2024
Motamed Cancer Institute
2012-2023
University of Tehran
2010-2021
Sharif University of Technology
2017
Abstract Subtle changes in the structure of nanoparticles influence their surface tension and corresponding interaction with cells proteins. Here, single wall carbon nanotube (SWCNT) multiwall (MWCNT) different tau protein was evaluated using a variety techniques including far near circular dichroism, fluorescence spectroscopy, dynamic light scattering, Zeta potential, TEM evaluation. Also cytotoxicity SWCNT MWCNT on PC12 cell line as model nervous system investigated by MTT, LDH, acridine...
There is a pressing need for further studies to categorize and validate circulating microRNAs (miRs) in breast cancer patients that can be one of the novel strategies screening monitoring. The present study aimed investigate expression candidate after operation, chemotherapy, radiotherapy non-metastatic patients. Tumor tissue plasma samples were collected from 30 with recently diagnosed Luminal A cancer. Control 10 healthy subjects. panel four miRs including miR-21, miR-55, miR-10b, Let-7a...
Introduction: Fumonisin B1 (FB1) is a toxic and carcinogenic mycotoxin produced in cereals due to fungal infection. This study was conducted determine FB1 contamination of rice corn samples its relationship with the rate esophageal cancer (EC) high risk area northeastern Iran. Methods: In total, 66 were collected from 22 geographical subdivisions Golestan province The levels measured for each subdivision by thin layer pressure liquid chromatographies. mean level proportions contaminated...
Herein, we have investigated the toxicity of SWCNTs and MWCNTs in vitro vivo, assessed their therapeutic effects on a typical animal model breast cancer order to obtain: first, cytotoxicity CNTs MC4L2 cell mice, second impact ablation tumor. especially were toxic organs induced death at high dosages. In this case, some liver cells showed relative shrinkage which was also confirmed by Annexin test cells. Moreover, decreased tumor volume. BCL2 gene down-regulated, BAX Caspase-3 up-regulated...
Abstract Folate-targeted iron oxide nanoparticles (FA@Fe 3 O 4 NPs) were prepared by a one-pot hydrothermal method and then used as cancer theranostic agents combining magnetic resonance imaging (MRI) hyperthermia therapy (MHT). Crystal structure, morphology, properties, surface functional group, heating efficacy of the synthesized characterized XRD, TEM, VSM, FTIR, analyses. The results indicated that crystal magnetite improved treatment. Toxicity NPs was assessed in vitro vivo on mammary...
Curcumin, a lipid-soluble compound extracted from the plant Curcuma Longa, has been found to exert immunomodulatory effects via macrophages. However, most studies focus on low bioavailability issue of curcumin by nano and microparticles, thus role macrophages in anticancer mechanism received little attention so far. We have previously shown potential biocompatibility, biodegradability anti-cancer dendrosomal (DNC). In this study, twenty-seven BALB/c mice were equally divided into control as...
Recently, some studies have focused on dendrimer nanopolymers as a magnetic resonance imaging (MRI) contrast agent or vehicle for gene and drug delivery. Considering the suitable properties of these materials, they are appropriate candidates coating iron-oxide nanoparticles which applied in hyperthermia. To best our knowledge, novelty this study is investigation fourth-generation dendrimer-coated (G4@IONPs) hyperthermia MRI.IONPs were synthesized via co-precipitation coated with fourth...
Methotrexate (MTX), a folic acid derivative, is potent anticancer used for treatment of different malignancies, but possible initiation drug resistance to MTX by cancer cells has limited its applications. Nanoconjugates (NCs) quantum dots (QDs) may favour the cellular uptake via folate receptors (FRs)-mediated endocytosis that circumvents efflux functions cells. We synthesised MTX-conjugated l-cysteine capped CdSe QDs (MTX-QD nanoconjugates) and evaluated their internalisation cytotoxicity...
We aimed to explore the lncRNA-miR-mRNA network in response Lactobacillus acidophilus (L. acidophilus) consumption rectal cancer patients. The candidate miRs were first taken from GEO and TCGA databases. constructed using high-throughput sequencing data. At last, we created a heatmap based on experimental data show possible correlation of selected targets. expression levels targets measured samples 107 patients undergoing placebo probiotic 10 noncancerous subjects Real-Time PCR. Our analysis...