A5051700958- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Cancer and Skin Lesions
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Reconstructive Surgery and Microvascular Techniques
- Metastasis and carcinoma case studies
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Sarcoma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Cancer survivorship and care
- Colorectal Cancer Surgical Treatments
- Cutaneous Melanoma Detection and Management
- Colorectal and Anal Carcinomas
- COVID-19 and healthcare impacts
- Esophageal and GI Pathology
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Advanced Breast Cancer Therapies
Tehran University of Medical Sciences
2016-2025
Motamed Cancer Institute
2012-2025
Iran University of Medical Sciences
2015-2024
Imam Khomeini Hospital
2008-2023
University of Tehran
2010-2023
Cancer Institute (WIA)
2011-2022
Islamic Azad University Medical Branch of Tehran
2021
Breast Center
2020
Shahid Beheshti University
2014
DKFZ-ZMBH Alliance
2010
Abstract Estrogen receptor α (ERα) upregulation causes abnormal cell proliferation in about two thirds of breast cancers, yet understanding the underlying mechanisms remains incomplete. Here, we show that high expression microRNA miR-375 ERα-positive lines is a key driver their proliferation. overexpression was caused by loss epigenetic marks including H3K9me2 and local DNA hypomethylation, dissociation transcriptional repressor CTCF from promoter, interactions ERα with regulatory regions...
There is a pressing need for further studies to categorize and validate circulating microRNAs (miRs) in breast cancer patients that can be one of the novel strategies screening monitoring. The present study aimed investigate expression candidate after operation, chemotherapy, radiotherapy non-metastatic patients. Tumor tissue plasma samples were collected from 30 with recently diagnosed Luminal A cancer. Control 10 healthy subjects. panel four miRs including miR-21, miR-55, miR-10b, Let-7a...
There is disagreement among studies of health-related quality life (HRQoL) changes in breast cancer patients over time. Reportedly, assessment HRQoL prior to diagnosis may be crucial provide a clear point comparison for later measurements. The aims this study were (1) investigate HRQoL, sense coherence (SOC), spirituality and religious coping group women with from the pre-diagnosis phase 6 months control group, (2) explore predictor role SOC, spirituality, within at 6-month follow-up.A...
Idiopathic Granulomatous Mastitis (IGM) is an uncommon inflammatory disease of the breast, with similar presentations as breast cancer and a relatively high recurrence rate. We reviewed demographics, clinical presentations, treatment modalities large cohort patients in Iran. Most had history pregnancy breastfeeding. The most common finding was pain palpable mass, respectively. received medical treatment, about half surgery. rate 24.8%, skin lesions were associated significantly higher odds...
Circular RNAs (circRNAs) characterize a novel kind of regulatory distinguished by great evolutionary conservation and constancy. Although their exact role in malignancies is not fully understood, they mainly work through specific axes. RNA/miRNA/mRNA axes affect the pathogenesis human cancers including breast cancer. We assessed expression function circ_0009910/miR-145-5p/MUC1 axis Breast Cancer tissues MCF-7 cells. Expression levels circ_0009910 MUC1 were notably increased cancer compared...
<b><i>Background:</i></b> Benefits and harms of screening mammography have been disputed in recent years. This fact, along with the limitations as well its unavailability all our medical centers, tempted us to evaluate accuracy thermography detecting breast abnormalities. <b><i>Patients Methods:</i></b> All patients who were candidates for biopsy examined by both before tissue sampling a referral center between January 2013 2014. We defined...
We aimed to report a large series of idiopathic granulomatous lobular mastitis (IGLM) from Iran and sketch preliminary clinical practice guidelines (CPG) for approaching an inflammatory breast mass.In retrospective records review, 43 consecutive IGLM cases were studied. Data on baseline, clinical, imaging, pathologic characteristics collected.The mean age the women was 33.5 years. All but 1 married had given birth. 16% cancer-like presentation. Inflammatory signs, architectural distortion,...
The goal of this study is to compare the response rate and recurrence available therapeutic modalities in treatment Idiopathic Granulomatous Mastitis (IGM). 374 patients with pathologically confirmed IGM, were included. They subdivided into three levels severity. Close observation had best lowest mild moderate cases. Severe cases mostly treated by prednisolone or underwent surgery. outcome use severe was comparable NSAIDs. Overall 9% resistant surgical intervention still an option among them.
Background: Cancer-associated fibroblasts (CAFs) play an important role in the initiation and progres- sion of tumor cells. These cells can trigger signaling pathways involved progression. HOTAIR, increased long non-coding RNA (lncRNA) breast cancer, has a vital tumorigenesis development cancer Methods: In this study, fibroblast cell culture medium was used to investigate its possible inducing HOTAIR expression PI3K/Akt/mTOR pathway CAFs normal (NFs) were isolated from tumors 6 patients with...
Idiopathic Granulomatous Mastitis (IGM) is an inflammatory and benign breast disease that can mimic a wide range of diseases (from infection to cancer (BC)). IGM affects women in the childbearing age more prevalent Asia. According similarity BC presentation different treatment pathways, it important distinguish between these two diseases. We present three cases; first one 42-year-old woman with 2 years after stage carcinoma; second third 46-year-old 41 old ladies 4 13 being diagnosed IGM....
Background: Idiopathic granulomatous mastitis (IGM) is a chronic breast disease with unknown pathophysiological and clinical aspects. Therefore, we designed this multi-center prospective case-control study to explore clarify the risk factors an acceptable sample size. Methods: From March 2021 December 2023, five hundred-four women histologically proven IGM were entered into group 504 healthy breasts included in control across nine centers. Participants' information was obtained by trained...
One of the limitations in treatment cancer patients with chemotherapy is development multidrug resistance (MDR). A well-known mechanism responsible for drug over-expression ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports many hydrophobic substrates and anti-cancer drugs out cell. MDR1 polymorphisms could alter expression level P-gp consequently result resistance. We investigated possible association between C3435T...
CD4+ and CD8+ T cells are the main types of lymphocytes in cell-mediated immunity play a central role induction efficient immune responses against tumors. The frequencies cell subtypes peripheral blood tumor tissues, draining lymph nodes (dLN) can be considered as useful markers for evaluation system cancers.In this study, blood, dLN samples breast cancer patients were compared with each other similar tissues from normal individuals. Immunophenotyping was carried out by flow cytometry...
Abstract Endocrine disrupting chemicals (EDCs) are organic compounds that have estrogenic activity and can interfere with the endocrine system. Bisphenol-A (BPA) is one of these which possess a potential risk for breast cancer. The aim this research was to evaluate BPA concentration in both urine adipose tissue samples cancer mastectomy mammoplasty patients study correlations levels groups. Urine from 41 11 were taken. concentrations detected using an ELISA assay. Urinary significantly...
<h3>Purpose:</h3> The aims of this study were to determine the incidence, clinicopathologic features, and prognostic factors ovarian involvement in primary colorectal cancer (CRC) also clear role prophylactic oophorectomy. <h3>Methods:</h3> Data from women with CRC treated between 1990 2004 retrieved, clinical pathologic features those who had undergone oophorectomy during surgery reviewed. <h3>Results:</h3> One hundred eighty cases (mean age, 48 years) included. In 120 cases, ovaries...
Skin Sparing Mastectomy (SSM) and immediate breast reconstruction has become increasingly popular as an effective treatment for patients with carcinoma. The aim of this study was to evaluate the clinical outcome skin sparing mastectomy in early cancer at a single population-based institution.Records ninety-five consecutive operable who had skin-sparing reconstructions between 1995 2003 were reviewed. Patient tumor characteristic, type reconstruction, postoperative complications, aesthetic...
Delayed presentation of symptomatic breast cancer is a public health issue in Iran, making major contribution to low survival. Despite the importance this problem, current knowledge insufficient inform interventions shorten patient delay. The aim study was explore factors influencing delay Iranian women with self-discovered symptom.This qualitative conducted during 2012-2013. Purposeful sampling used recruit 20 symptoms who attended Cancer Institute Tehran University Medical Sciences,...
Background: The true association between breast cancer and vitamin D is currently under investigation. We compared serum 25-hydroxy-vitamin levels in women with benign malignant masses controls. Materials Methods: Levels of were measured by electrochemiluminescense. Serum >35 ng/ml, 25-35 12.5-25 ng/ml <12.5 considered as normal, mild, moderate severe deficiency, respectively. Results: Overall, 364 included the control, 172 136 groups. median level was significantly lower cancers than also...
Late relapses of testicular germ cell tumor are uncommon. We report a case cervical mature teratoma appeared 17 years after treatment teratocarcinoma. A 20- year- old patient underwent left sided orchiectomy followed by systemic therapy and retroperitoneal residual mass resection in 1989. He remained complete remission for 200 months. In 2005 huge supraclavicular neck with extension to anterior mediastinum appeared. Radical surgical the was performed pathologic examination revealed teratoma....