A5021533125- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Advanced MRI Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- Ultrasonics and Acoustic Wave Propagation
Erasmus MC Cancer Institute
2017-2022
Erasmus MC
2019
Recently, some studies have focused on dendrimer nanopolymers as a magnetic resonance imaging (MRI) contrast agent or vehicle for gene and drug delivery. Considering the suitable properties of these materials, they are appropriate candidates coating iron-oxide nanoparticles which applied in hyperthermia. To best our knowledge, novelty this study is investigation fourth-generation dendrimer-coated (G4@IONPs) hyperthermia MRI.IONPs were synthesized via co-precipitation coated with fourth...
Background: Addition of deep hyperthermia to radiotherapy results in improved local control (LC) and overall survival compared alone cervical carcinoma patients. Based on preclinical data, the time interval between is expected influence treatment outcome. Clinical studies addressing effect are sparse. The repercussions for clinical applications substantial, as should be kept short possible. In this study, we therefore investigated Methods: We analyzed all primary patients treated 1996 2016...
Background: Radiofrequency (RF) mild hyperthermia (40 °C–44 °C for 60 minutes) is an effective adjuvant treatment several types of cancer. To ensure efficacy, quality assurance (QA) necessary. This study presents the first systematic 3D characterisation heating performance commonly used Pyrexar BSD2000-3D MR-compatible applicator using magnetic resonance temperature imaging (MRTI).Methods: A reproducibly positioned phantom was heated with a power 1000 watts during 12.4 min needed to measure...
Clinical outcome of hyperthermia depends on the achieved target temperature, therefore conformal heating is essential. Currently, invasive temperature probe measurements are gold standard for monitoring, however, they only provide limited sparse data. In contrast, magnetic resonance thermometry (MRT) provides unique capabilities to non-invasively measure 3D-temperature. This study investigates MRT accuracy MR-hyperthermia hybrid systems located at five European institutions while a centric...
Purpose The linear change of the water proton resonance frequency shift (PRFS) with temperature is used to monitor based on temporal difference image phase. Here, effect motion‐induced susceptibility artifacts phase was studied in context mild radio hyperthermia pelvis. Methods First, respiratory‐induced field variations were disentangled from digestive gas motion projection onto dipole fields (PDF) as well Laplacian boundary value (LBV) algorithm applied data eliminate artifacts. Both...
Purpose MR temperature monitoring of mild radiofrequency hyperthermia (RF‐HT) cancer exploits the linear resonance frequency shift water with temperature. Motion‐induced susceptibility distribution changes cause artifacts that we correct here using total field inversion (TFI) approach. Methods The performance TFI was compared to two background removal (BFR) methods: Laplacian boundary value (LBV) and projection onto dipole fields (PDF). Data sets spatial change ‐drift were simulated, phantom...
To evaluate the feasibility and efficacy of deep regional hyperthermia with use mobile insulator sheets in a capacitively coupled heating device.The heat was applied using an 8-MHz radiofrequency-capacitive device. The sheet inserted between regular bolus cooled overlay each upper lower side electrode. Several settings were investigated experimental study agar phantom to temperature distributions. specific absorption rate (SAR) distributions several organs also computed for three-dimensional...
Introduction Within the hyperthermia community, consensus exists that clinical outcome of treatment radiotherapy and/or chemotherapy plus (i.e. elevating tumor temperature to 40 − 44 °C) is related applied thermal dose; hence, quality crucial for success prospective multi-institution trials. Currently, applicator assurance (QA) measurements are implemented independently at each institution using basic cylindrical phantoms. A comparison heating magnetic resonance thermometry (MRT) and...