A5059085634- Parkinson's Disease Mechanisms and Treatments
- Sulfur Compounds in Biology
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- Viral Infections and Immunology Research
- Glutathione Transferases and Polymorphisms
- Neurological disorders and treatments
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Spinal Fractures and Fixation Techniques
- Cancer, Hypoxia, and Metabolism
- Hip and Femur Fractures
- Medical Imaging and Analysis
- Carcinogens and Genotoxicity Assessment
- Vascular Procedures and Complications
- Eicosanoids and Hypertension Pharmacology
- Respiratory Support and Mechanisms
- HIV Research and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Molecular Biology Techniques and Applications
- Pharmacogenetics and Drug Metabolism
- Heart Failure Treatment and Management
- Salivary Gland Disorders and Functions
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
Central South University
2024-2025
Second Xiangya Hospital of Central South University
2024-2025
National Clinical Research
2025
Chengde Medical University
2025
Sichuan University
2009-2024
West China Hospital of Sichuan University
2009-2024
Beijing Haidian Hospital
2024
Tianjin Medical University
2024
Dali University
2024
Second Hospital of Hebei Medical University
2024
Objectives To explore the differences in features and impact on quality of life (QOL) non-motor symptoms (NMS) tremor dominant (TD) postural instability gait disorder (PIGD) phenotypes early Parkinson's disease (PD), as well determinants poor QOL for TD PIGD phenotypes. Methods This cross-sectional study recruited 301 patients with PD 101 healthy controls. Specific assessments used NMS included scale (NMSS), Hamilton Rating Scale Depression (HRSD-24), Anxiety (HAMA), Mini-Mental state...
The objective of this study is to develop an automated method for segmenting spleen computed tomography (CT) images using a deep learning model. This approach intended address the limitations manual segmentation, which known be susceptible inter-observer variability. Subsequently, prediction model gastric cancer (GC) serosal invasion was constructed in conjunction with radiomics and features, nomogram generated explore clinical guiding significance. enrolled 311 patients from two centers...
The present study was designed to investigate whether endogenous sulphur dioxide (SO2) controlled pulmonary inflammation in a rat model of oleic acid (OA)-induced acute lung injury (ALI). In this model, adenovirus expressing aspartate aminotransferase (AAT) 1 delivered the lungs, and levels SO2 proinflammatory cytokines tissues were measured. human alveolar epithelial cell line A549, nuclear translocation DNA binding activities wild-type (wt) C38S (cysteine-to-serine mutation at p65 Cys38)...
The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined screening with functional characterizations identify novel loci and candidate genes for CAD.We performed genome-wide followed by multicenter validation in 8 cohorts consisting of 21 828 participants Han ethnicity identified 3 intragenic SNPs (single nucleotide polymorphisms), rs9486729 (SCML4 [Scm polycomb group protein-like 4]; odds ratio, 1.25; 95% CI, 1.17-1.34; P=3.51×10-11), rs17165136 (THSD7A...
Management of salivary gland hypofunction caused by irradiation (IR) therapy for head and neck cancer remains lack effective treatments. Salivary glands, especially the parotid gland, actively uptake dietary nitrate secrete it into saliva. Here, we investigated effect on prevention treatment IR-induced in miniature pigs, elucidated underlying mechanism human cells. We found that administration prevented damage a dose-dependent manner, maintaining function irradiated tissue. Nitrate could...
The study was designed to explore the role and possible mechanisms of hydrogen sulfide (H2S) in regulation myocardial collagen remodeling spontaneously hypertensive rats (SHRs). We treated nine-week-old male SHRs age- sex-matched Wistar-Kyoto (WKYs) with NaHS (90 µmol/kg−1-day−1) for 9 wks. At 18 wks, plasma H2S, tail arterial pressure, morphology heart, ultrastructure volume fraction (CVF), expressions I III protein procollagen mRNA, transforming growth factor-β1 (TGF-β1), TGF-β type...
Background It has been noticed that the patients with multiple system atrophy (MSA) can accompany depression and anxiety. This study aimed to establish incidence determinants of anxiety symptoms in Chinese MSA patients. Methods A total 237 were enrolled study. Neuropsychological assessment was performed using Hamilton Depression Rating Scale-24 items Anxiety Scale. Results We found 62.0% 71.7% had at least mild symptoms, respectively. The severity associated lower educational years (P=.024),...
The prevalence of “vaping” has recently seen significant increases in North America, especially adolescents. However, the behavioral correlates vaping are largely unexplored. uptake existing technologies meant for rodent vapor inhalation remains limited because a lack affordability and versatility (ability to be used with variety vaporizers). OpenVape (OV) offers an open-source, low-cost solution that can research contexts. Here, we present specific use case, combining OV apparatus JUUL...
Among non-smokers, the factors resulting in lung carcinogenesis are poorly understood. We conducted a hospital-based case-control analysis of 294 Chinese women, whom 217 were to evaluate role polymorphic N-acetyltransferase (NAT2) as susceptibility factor for disease. The proportion slow acetylator genotypes among non-smoking cases (n = 92) and controls 125) was 38.0 24.0%, respectively [odds ratio (OR) 2.0, 95% confidence interval (CI) 1.1–3.7]. No effect NAT2 genotype seen smokers. marked...
There is increasing evidence for the role of heterocyclic and other arylamines in carcinogenesis, including lung carcinogenesis. Chinese women have a high rate cancer despite low smoking prevalence, studies this population may provide useful information on risk factors than smoking. Hepatic CYP1A2 NAT2 are involved metabolism carcinogenic arylamines, also catalyzes detoxification pathway these compounds. In study, we examined effect activity using urinary caffeine metabolic ratio assay 54...