A5007776098- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Gut microbiota and health
- Retinal Imaging and Analysis
- Nitric Oxide and Endothelin Effects
- Prostate Cancer Diagnosis and Treatment
- Ocular Disorders and Treatments
- Ocular Infections and Treatments
- Electron Spin Resonance Studies
- Nuclear Engineering Thermal-Hydraulics
- Diet and metabolism studies
- Heat Transfer and Boiling Studies
- Connexins and lens biology
- Mycobacterium research and diagnosis
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Heat transfer and supercritical fluids
- Neuroblastoma Research and Treatments
- Anorectal Disease Treatments and Outcomes
- Retinopathy of Prematurity Studies
- Subcritical and Supercritical Water Processes
- Inflammatory Bowel Disease
- Neurological Disease Mechanisms and Treatments
- Time Series Analysis and Forecasting
- Adipose Tissue and Metabolism
Sichuan University
2013-2025
West China Hospital of Sichuan University
2020-2025
State Key Laboratory of Biotherapy
2020-2025
Beijing University of Posts and Telecommunications
2024
Electric Power University
2023
Northeast Electric Power University
2023
Affiliated Hospital of Guizhou Medical University
2022
Guiyang Medical University
2022
Shanghai Jiao Tong University
2019
Shanghai First People's Hospital
2019
Introduction Recently the role of gut microbial dysbiosis in many ocular disorders, including but not limited to uveitis, age-related macular degeneration (AMD), diabetic retinopathy (DR), dry eye, keratitis and orbitopathy is a hot research topic field. Targeting microbiota treat these diseases has become an unstoppable trend. Bibliometric study visualization analysis have essential methods for literature medical We aim depict this area's hotspots future directions by bibliometric software...
This study aims to clarify the disruption of gut barrier and dysbiosis microbiota in an experimental macaque model with 6-year diabetes mellitus (DM), provide evidence for application therapeutic strategies targeting human future. A single intravenous injection high-dose streptozotocin was used induce type 1 (T1D) model. Hematoxylin-Eosin (HE) Periodic Acid Schiff (PAS) staining were conducted observe colon morphological changes. The composition detected using 16S rRNA gene sequencing,...
This study is designed to generalize and depict the research hotspots of endophthalmitis through bibliometric methods software analyze evolutive tendency work on this severe disease over past 30 years. employed a rigorous approach. We identified all endophthalmitis-related literature by conducting comprehensive search Science Citation Index Expanded database under Web Core Collection. The data was then analyzed visualized using CiteSpace VOSviewer, two widely recognized tools in field...
Abstract Objectives 5α‐reductase inhibitor (5‐ARI) is a commonly used medicine in the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Our study mainly focuses on mechanism BPH development after 5ARI treatment. Materials and Methods Prostate specimens from patients were collected. Insulin‐like growth factor 1 (IGF‐1), Beclin‐1, LC3 levels, was analysed by immunohistochemistry. The role IGF‐1 autophagic flux prostate epithelial cells...
Abstract Background: Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy (DR) remain inconclusive. This study aimed to determine whether retinal manifestations abnormal glucose metabolism (AGM) patients differ from those the healthy individuals. Methods: PubMed, Embase, Web of Science were searched between 2000 2021. The eligibility criteria AGM without DR. Primary secondary outcomes measured by optical coherence tomography (OCT) OCT...
Introduction: Chemicals, such as MNU (N-methyl-N-nitrosourea) and NaIO3 (sodium iodate), are widely used to induce retinal degeneration in rodents. Streptozotocin (STZ) is an analog of N-acetyl glucosamine which moiety linked a hexose has special toxic effect on insulin-producing pancreatic β-cells. It commonly hyperglycemia model diabetes. While intracerebroventricular injection STZ can produce Alzheimer's disease independent hyperglycemia, most studies using focus the effects retina, but...
BackgroundDiabetic retinopathy (DR) is a common complication in diabetic patients. DR also neurodegenerative disease. Patients with hyperglycemia, hyperlipidemia, and hypertension are vulnerable to development. While the roles of blood glucose pressure development have been extensively studied, relationship between body fat pathogenesis impact lipid-reducing drugs on has just emerged as research hotspot study. We aim visualize contributions cooperation reporters, organizations, nations,...
Microphthalmos (MCO) is a rare developmental defect characterized by small malformed eyes. Our study aimed to describe the clinical characteristics of posterior microphthalmos syndrome caused novel variant in MFRP gene Chinese patient. Complete ophthalmologic examinations were performed for proband and proband's family members. Whole exon sequencing (WES) Sanger used identify mutated genes, bioinformatic analysis was undertaken predict effect this variant. Clinical showed that had reduced...
To observe the protective effects of L-citrulline on renal I/R injury and elucidate mechanisms involved, 48 rats were randomized into eight groups: Group 1: sham operated; 2: (45 min ischaemia 24 h reperfusion); 3: + (300 mg/kg, i.g.); 4: (600 5: (900 6: normal saline (NS, 7: N sup ω nitro-L-arginine ester (L-NAME, 20 i.p.); 8: i.g.) L-NAME (20 mg/ kg, i.p.). At end reperfusion period, serum was collected kidneys underwent histological biochemical examinations. Our results showed that...
In the LNG regasification process, printed circuit heat exchangers(PCHE) is an ideal choice for vaporizer, with propane as intermediate working medium in hot side of PCHE. this work, numerical simulations condensation flow and transfer at different operating parameters was carried out a semi-circular straight channel The micro-segment analysis method used to present local coefficient pressure drop channel. results indicate that process can be divided into three stages: “constant temperature...
Purpose: Congenital cataract (CC) is a common disease resulting in leukocoria and the leading cause of blindness children worldwide. Approximately 50% congenital inherited. Our aim to identify mutations Chinese family with cataract. Methods: A four-generation diagnosed was recruited West China Hospital Sichuan University. Genomic DNA extracted from peripheral blood these participants. All coding exons flanking regions were amplified sequenced, variants validated using Sanger sequencing....
Objective To observe the clinical effect of surgery combined with traditional Chinese medicine in treatment sacrococcygeal pilonidal sinus. Methods Retrospective analysis characteristics 18 patients sinus was conducted. Results 18 cases recurrent infection, five whom were misdiagnosed other hospitals; treated surgery, pathological diagnosis showed foreign body granuloma, which coincidence diagnostic criteria sinus.All these herbal fumigation and washing clearing away heat,...