A5050957984- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Cancer-related molecular mechanisms research
- Pelvic floor disorders treatments
- Genetic factors in colorectal cancer
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Research and Splicing
- Inflammasome and immune disorders
- Phytoestrogen effects and research
- Prostate Cancer Treatment and Research
Shanghai First People's Hospital
2017-2022
Shanghai Jiao Tong University
2017-2022
Abstract Quaking homolog (QKI) is a member of the RNA‐binding signal transduction and activator proteins family. Previous studies showed that QKI possesses tumour suppressor activity in human cancers by interacting with 3'‐untraslated region (3'‐UTR) various gene transcripts via STAR domain. This study first assessed association QKI‐6 expression clinicopathological survival data from bladder cancer patients then investigated underlying molecular mechanisms. Bladder tissues (n = 223) were...
Complications after a thulium laser resection of the prostate (TmLRP) are related to re-epithelialization prostatic urethra. Since growth and development induced by androgen, aim this study was determine role explore mechanism androgen in wound healing urethra.Beagles that received TmLRPs were randomly distributed into castration group, testosterone undecanoate (TU) control group. The assessed once week using cystoscope. Histological analysis then carried out urethra each inflammatory...
Background Increased prostatic smooth muscle tone and hyperplastic growth contribute to urethral obstruction voiding symptoms in benign hyperplasia (BPH). It has been suggested that different proliferative potential of stromal cells between transition zone (TZ) adjoining regions the prostate plays a significant role development BPH. However, molecular mechanisms this process remain unclear. We found tumor necrosis factor receptor‐associated 6 (TRAF6) highly expressed TZ compared peripheral...
Abstract Objectives 5α‐reductase inhibitor (5‐ARI) is a commonly used medicine in the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Our study mainly focuses on mechanism BPH development after 5ARI treatment. Materials and Methods Prostate specimens from patients were collected. Insulin‐like growth factor 1 (IGF‐1), Beclin‐1, LC3 levels, was analysed by immunohistochemistry. The role IGF‐1 autophagic flux prostate epithelial cells...
Background This study investigated shallow heat injury to prostate stromal fibroblasts and epithelial cells their interaction regulate the wound healing underlying molecular events. Methods Prostate were cultured individually or cocultured subjected for assessments of cell proliferation, migration, apoptosis, cycle distribution, gene expression. The supernatant heat‐injured WPMY‐1 was collected exosome extraction assessments. Furthermore, beagle dogs received thulium laser resection (TmLRP)...
Abstract The sterile inflammation (SI) of the urinary tract is a common problem requiring serious consideration after prostatectomy. This study mainly focuses on role reactive oxygen species–NLR family, pyrin domain‐containing 3 (ROS–NLRP3) signaling pathway in SI thulium laser resection prostate (TmLRP). Urinary cytokines were determined patients who received TmLRP, and heat shock protein 70 (HSP70) was detected resected tissues. involvement ROS HSP70‐induced explored THP‐1 cells with or...