A5100712787- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Lipid metabolism and biosynthesis
- Ubiquitin and proteasome pathways
- Nutrition, Genetics, and Disease
- NF-κB Signaling Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Spine and Intervertebral Disc Pathology
- Cell death mechanisms and regulation
- Curcumin's Biomedical Applications
- Glycogen Storage Diseases and Myoclonus
- Reconstructive Surgery and Microvascular Techniques
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Osteomyelitis and Bone Disorders Research
Tianjin Medical University Eye Hospital
2024
Tianjin Medical University
2024
Nankai University
2024
Capital Medical University
2008-2024
Beijing Tongren Hospital
2007-2024
Beijing Jishuitan Hospital
2024
Peking University
2021-2024
Yan'an Hospital Affiliated To Kunming Medical University
2023
Kunming Medical University
2023
Sun Yat-sen University
2023
HER2 gene amplification generates an enormous number of transcripts, but the global effects on endogenous miRNA targets including HER family members in breast cancer are unexplored. We generated a HER2–3’UTR expressing vector to test tumor-promoting properties low T47D and MCF7 cells. Through microarray analysis real-time PCR we identified genes that were regulated by HER2–3’UTR. Positive negative manipulation expression, response element mutational studies transcript reporter assays...
Ginsenoside Rh2 has been shown to have an antitumor effect on a wide range of cancers.A previous study that ginsenoside can inhibit the proliferation human lung adenocarcinoma A549 cell line in dose-dependent manner by X. Liu et al.Genetics and Molecular Research 15 (3): gmr.15039003activating caspase-8/3 activity promote apoptosis.However, association JNK signaling pathways transcription factors with suppression non-small cancer not yet reported.In this study, we found activate JNK/MAPKs...
The aim of this study was to evaluate the effect mild hypothermia on coagulation-fibrinolysis system and physiological anticoagulants after cardiopulmonary resuscitation (CPR). A total 20 male Wuzhishan miniature pigs underwent 8 min untreated ventricular fibrillation CPR. Of these, 16 were successfully resuscitated randomized into group (MH, n = 8) or control normothermia (CN, 8). Mild (33°C) induced intravascularly, temperature maintained for 12 h before actively rewarmed. CN received...
Hepatocellular carcinoma (HCC), one of the most common malignant cancers, is third leading cause cancer-related mortality worldwide.The etiological factors HCC include alcohol intake, smoking, viral infections, cirrhosis, non-alcoholic steatohepatitis, hemochromatosis, and diabetes.Nowadays, despite much advance in treatment, 5-year survival rate for patients keeps dismal due to recurrence metastases HCC.Cancer stem cells (CSCs), also termed tumor-initiating cells, have capability...
Advances in chemotherapeutic strategies are urgently required to improve antitumor efficiency. Herein, a carboxylated pillar[6]arene (CP6A) was employed load chemotherapy medication, nitrogen mustard (NM), via forming direct host–guest complex, as this helps decrease the cytotoxicity of NM on normal mammary epithelial cells. Attributed stronger complexation ability CP6A for endogenous spermine (SPM) than NM, complexed could be competitively released from cavity replacement with SPM. This...
Drug-eluting microspheres are commonly used as a local drug delivery system for interventional therapy. However, current drug-eluting have poor X-ray visibility, which can hinder tracking and postembolization evaluation. In the study, X-ray-visible poly(acrylic acid) beads loaded with iodized oil (IO-PAA-DEBs) ranging from 100-300 μm were prepared evaluated both in vitro vivo. Iodized served radiopaque agent, computed tomography scanning confirmed that exhibited excellent properties. The...