A5101442725- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Blood groups and transfusion
- Genetic factors in colorectal cancer
- Blood donation and transfusion practices
- Atherosclerosis and Cardiovascular Diseases
- Herpesvirus Infections and Treatments
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Chronic Lymphocytic Leukemia Research
- Blood Coagulation and Thrombosis Mechanisms
- NF-κB Signaling Pathways
- Toxoplasma gondii Research Studies
- Reproductive Biology and Fertility
- Breast Lesions and Carcinomas
- Tryptophan and brain disorders
- Flavonoids in Medical Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Second Affiliated Hospital of Harbin Medical University
2011-2023
Harbin Medical University
2011-2023
Sun Yat-sen University
2023
Peking University
2021
Beijing HuiLongGuan Hospital
2021
Xi'an Jiaotong University
2021
Chinese PLA General Hospital
2021
Kunming Medical University
2020
Yan'an Hospital Affiliated To Kunming Medical University
2020
Cavities are important in clinical diagnosis of pulmonary tuberculosis (TB) infected by Mycobacterium tuberculosis. Although microRNAs (miRNAs) play a vital role the regulation inflammation, relation between plasma miRNA and with cavity remains unknown. In this study, samples were derived from 89 cavitary (CP-TB) patients, non-cavitary (NCP-TB) patients 95 healthy controls. Groups matched for age gender. screening phase, Illumina high-throughput sequencing technology was employed to analyze...
Except host and environmental factors influencing individual human cytokine responses, pre-analytical handling procedures detection methods also affect levels. In this study, we used cytometric bead array (CBA) chemiluminescence (ECL). These two were to test serum plasma samples from 50 healthy adult volunteers rheumatoid arthritis (RA) patients' We evaluated the impact of storage temperature, collection times, additives in tubes on measurement IL-6, IL-8, TNF-α. The finding study first...
Gestational diabetes mellitus (GDM), a heritable metabolic disorder and the most common pregnancy-related condition, remains understudied regarding its genetic architecture potential for early prediction using data. Here we conducted genome-wide association studies on 116,144 Chinese pregnancies, leveraging their non-invasive prenatal test (NIPT) sequencing data detailed records. We identified 13 novel loci GDM 111 five glycemic traits, with minor allele frequencies of 0.01-0.5 absolute...
This study focused on the potential therapeutic effect of baicalin collagen-induced arthritis (CIA) in rats and underlying mechanisms. The CIA were injected with (50, 100, or 200 mg/kg) once daily for 30 days. monitored clinical severity arthritis, joint tissues used radiographic assessment histologic examination. We quantified tumor necrosis factor–<i>α</i> (TNF-<i>α</i>) interleukin-1<i>β</i> (IL-1<i>β</i>) experimental animals Western blots to assess levels protein abundance,...
Due to the increase in prevalence and incidence of allergic diseases, improving sensitivity specificity screening indexes is critical. Total immunoglobulin E (IgE) a traditional index for judging while its relatively poor. Serum-specific IgE (sIgE) an objective with high diagnosis diseases. In present research, total sIgE 3,721 patients diseases were analyzed further illuminate association between them. The data derived from patients. serum-sIgE 14 types common allergens detected. A 2,419...
Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnosed gestational thrombocytopenia (GT), characterized by a more marked decrease in platelet during pregnancy. However, the underlying biological mechanism behind these phenomena remains unclear. Here, we used sequencing data from noninvasive prenatal testing 100 186 Chinese individuals and conducted, our knowledge, hitherto largest-scale genome-wide association studies on counts 5 periods...
The aim of this study was to analyze the changes in complements C3 and C4 C-reactive protein (CRP) patients with systemic lupus erythematosus (SLE) rheumatoid arthritis (RA), evaluate role these indices differential diagnosis SLE RA. first 347 SLE, 382 RA 66 erythema nodosum were selected for measurement complement CRP levels serum, control group. roles disease activity evaluation analyzed SPSS 13.0. Complement significantly reduced compared those However, patients, level increased. In...
Microvesicle biogenesis is a highly regulated process. Aberrant release of microvesicles from cancer cells have been associated with their invasiveness and prognosis. However, the mechanism aberrant remains poorly understood. Herein, we found that hepatocellular carcinoma shed more than normal hepatocytes miR-200a were shown to inhibit in cells. Then, confirmed might target Gelsolin change cytoskeleton regulate secretion. Further may proliferation adjacent by inhibiting microvesicles....
Background CD28 is one of a number costimulatory molecules that play crucial roles in immune regulation and homeostasis. Accumulating evidence indicates factors influence breast carcinogenesis. To clarify the relationships between polymorphisms gene carcinogenesis, case-control study was conducted women from Heilongjiang Province northeast China. Methodology/Principal Findings Our research subjects consisted 565 female patients with sporadic cancer 605 age- sex-matched healthy controls. In...
Patients with anti-β2GPI antibodies display significantly higher platelet activation/aggregation and vascular endothelial cell damage. The mechanism underlying the correlation between activation, dysfunctions remains unknown.In this study, we derived miR-96 -26a from platelets activated by anti-β2GPI/β2GPI complex explored their role in modulating human umbilical vein (HUVEC) migration tube formation.Anti-β2GPI/β2GPI induces release of platelet-derived microparticles (p-MPs). amounts these...
As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several members, thus HVEM plays different roles in T cell immunity. and its ligands have been involved the pathogenesis of various autoimmune, inflammatory diseases tumors. In current study, we conducted case-control study comparing polymorphisms breast cancer. Subjects included 575 females cancer 604 age-matched healthy controls. Six SNPs (rs2281852, rs1886730, rs2234163, rs11573979, rs2234165, rs2234167) were...
OX40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction OX40-OX40L involved pathogenesis multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease cancer. genetic variants can increase risk SLE, atherosclerosis, sclerosis show gender-specific effects some studies. Accordingly, we performed case-control study including 557 breast cancer patients 580 age-...
The aim of this study was to investigate the effect different heparin concentrations in course sexed vitro fertilization (IVF), on bovine embryonic development and term following embryo transfer (ET). With a total 9156 oocytes for IVF, sorted as well unsorted sperm from four bulls had requirements achieving highest rate vitro. However, when optimal were used (40 80 µg/ml), performance X-sorted (0.3 × 106/ml/IVF droplet) all bulls, judged by blastocyst (Bulls A, B, C, D: 25.2, 19.7, 25.1,...
Background: Studies have suggested retinal nerve fiber layer (RNFL) involvement in the pathogenesis of schizophrenia. Additionally, research has shown that vascular endothelial growth factor (VEGF) potentially contributes to pathophysiology psychiatric disorders. Therefore, this study aimed investigate VEGF, RNFL, and correlations with cognitive impairments schizophrenia patients. Methods: Patients (n = 138) were compared healthy controls 160). RNFLs measured optical coherence tomography...
// Yupeng Liu 1 , Yibaina Wang Fulan Hu Hongru Sun Zuoming Zhang Xuan Xiang Luo Lin Zhu Rong Huang Yan Li Guangxiao Xia Shangqun Fan Yanhong 2 Jiesheng 3 Huiping Yuan 4 and Yashuang Zhao Department of Epidemiology, Public Health College, Harbin Medical University, 150081, Heilongjiang Province, The People's Republic China Clinical Laboratory, Second Affiliated Hospital Orthopedics Surgery, Key Laboratory Ophthalmology, Correspondence to: Zhao, email: zhao_yashuang@263.net Keywords:...
Abstract Given that E3 ubiquitin ligases (E3) regulate specific protein degradation in many cancer-related biological processes. copy number variation (CNV) may affect the development and prognosis of colorectal cancer (CRC). Therefore, we detected CNVs five genes 518 CRC patients age, gender residence matched controls China estimated association between gene risk prognosis. We also their interactions with environmental factors risk. find a significant MDM2 (amp v.s. wt: odds ratio = 14.37,...
An expedient and cost-effective diagnostic tool is needed to complement galactography exfoliative cytology for detection of benign or malignant breast diseases with nipple discharge. The aim this prospective study explore the utility carcinoembryonic antigen, cancer antigen 15-3 125 levels in discharge diagnosis various diseases. We evaluated pre-operative tumor marker 153 samples collected from one both breasts 142 women undergoing surgery. Patients underwent auxiliary examination...
Trace elements (TEs) are essential for the treatment of rheumatoid arthritis (RA). This study aimed to prepare a TEs solution enriched with various organic states evaluate its preventive, therapeutic effects, and mechanism action in RA provide method treatment. The natural ore were extracted added 0.5% (W/V) L-alanyl-L-glutamine (LG) obtain (LG-WLYS), which was examined concentration quality. antioxidant properties effects LG-WLYS on cell behavior evaluated at cellular level. preventive rats...