A5027179151- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Brain Metastases and Treatment
- Pregnancy and preeclampsia studies
- Lung Cancer Research Studies
- IL-33, ST2, and ILC Pathways
- Glioma Diagnosis and Treatment
- Gestational Diabetes Research and Management
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- NF-κB Signaling Pathways
- Cancer-related cognitive impairment studies
- Advanced Radiotherapy Techniques
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic Associations and Epidemiology
- Platelet Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Gene expression and cancer classification
- Thyroid Disorders and Treatments
- Chemokine receptors and signaling
Shenzhen Children's Hospital
2020-2024
Guangdong 999 Brain Hospital
2018-2024
Areté Associates (United States)
2023
Sun Yat-sen University
2023
Shenzhen University
2022
Shenzhen Blood Center
2013-2021
Maternal and Child Health Care Hospital of Bao'an
2016-2019
Jinan University
2018
Shenzhen Maternity and Child Healthcare Hospital
2017
Southern Medical University
2013-2014
Abstract Aims/hypothesis Gestational diabetes mellitus (GDM) is the most common disorder in pregnancy; however, its underlying causes remain obscure. This study aimed to investigate genetic and molecular risk factors contributing GDM glycaemic traits. Methods We collected non-invasive prenatal test (NIPT) sequencing data along with four 55 biochemical measurements from 30,699 pregnant women during a 2 year period at Shenzhen Baoan Women’s Children’s Hospital China. Genome-wide association...
Abstract Human natural killer (NK) cells are essential for controlling infection, cancer, and fetal development. NK cell functions modulated by interactions between polymorphic inhibitory immunoglobulin-like receptors (KIR) HLA-A, -B, -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand contribute to reproduction immunity. In contrast, only some HLA-A -B they focus By high-resolution analysis of genes, we show that the Chinese Southern Han (CHS) significantly enriched...
Explicitly sharing individual level data in genomics studies has many merits comparing to summary statistics, including more strict QCs, common statistical analyses, relative identification and improved power GWAS, but it is hampered by privacy or ethical constraints. In this study, we developed encG-reg, a regression approach that can detect relatives of various degrees based on encrypted genomic data, which immune The encryption properties encG-reg are the random matrix theory masking...
Gestational diabetes mellitus (GDM), a heritable metabolic disorder and the most common pregnancy-related condition, remains understudied regarding its genetic architecture potential for early prediction using data. Here we conducted genome-wide association studies on 116,144 Chinese pregnancies, leveraging their non-invasive prenatal test (NIPT) sequencing data detailed records. We identified 13 novel loci GDM 111 five glycemic traits, with minor allele frequencies of 0.01-0.5 absolute...
Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnosed gestational thrombocytopenia (GT), characterized by a more marked decrease in platelet during pregnancy. However, the underlying biological mechanism behind these phenomena remains unclear. Here, we used sequencing data from noninvasive prenatal testing 100 186 Chinese individuals and conducted, our knowledge, hitherto largest-scale genome-wide association studies on counts 5 periods...
The interaction of natural killer (NK) cell inhibitory receptors with polymorphic HLA class I molecules educates NK cells for immune surveillance against tumor cells. KIR A haplotype, which encodes distinct that bind certain HLA-A, -B and -C allotypes, is unusually frequent in East Asians. Focusing on Chinese southern Han, we analyzed 472 acute lymphoblastic leukemia (ALL), 433 myeloid (AML), 193 chronic (CML) patients, 745 healthy controls. We observed a higher frequency homozygosity the...
Abstract Background & Aims Intrahepatic cholestasis of pregnancy (ICP) is the most common and high-risk liver disorder during critical period human reproduction. Despite varying prevalence across populations, a mechanistic understanding this phenomenon lacking. This study delves into genetic etiology ICP in East Asians, drawing comparisons with Europeans to comprehend context background evolution. Methods We conducted hitherto largest-scale genome-wide association studies (GWAS) on total...
Emerging evidence indicated that changes in DNA methylation early breast cancer (BC) development might be clinically relevant for therapeutic decisions. Through analysis of whole-genome gene expression microarray and microarray, we explored genes with abnormal BC detection. Firstly, human tissues adjacent non-cancerous were collected from nine patients. Gene sequencing was conducted identifying differentially expressed methylated BC. Differentially further using the Cancer Genome Atlas...
Apart from presenting peptides to T cells, class I HLA molecules serve as ligands for killer cell immunoglobulin-like receptor (KIRs) and regulate the response of natural (NK) cells. The role played by KIR in acute rejection (AR) following liver transplantation has been controversial. In this retrospective study, we assessed influence alleles, matching between donor-recipient pairs, recipient donor on AR southern Chinese. total, 143 recipients 78 donors obtained a single transplant center...
To study the genetic polymorphisms of human leukocyte antigen (HLA)- A, B, C, DRB1, DQA1, DQB1, DPA1and DPB1among ethnic Hans from southern China.481 randomly selected individuals were genotyped using a polymerase chain reaction (PCR) sequence-based typing (SBT) method for above genes. Their allele frequencies determined by direct counting.In total, 28 HLA-A, 57 HLA-B, HLA-C, 40 HLA-DRB1, 18 HLA-DQA1, 17 HLA-DQB1, 6 HLA-DPA1and 21 HLA-DPB1alleles identified. Among these, common alleles (with...
The novel HLA‐DPB1 *166:01 allele differs from the closest DPB1 *152:01 by a single missense mutation at CDS nt 315G>A in exon 2.
Abstract HLA ‐ C*04:162 differs from the closely matching allele C*04:01:01:01 by one nucleotide substitution in exon 4 at position 883 A/G.
A novel allele HLA-A*11:188 differs from HLA-A*11:01:01 by a single mutation at position 439 in exon 3.
Abstract KIR2DL2 and KIR2DL3 segregate as alleles of the same killer cell immunoglobulin‐like receptor (KIR) gene locus. They have been associated with viral infectious diseases certain cancers their allelic information may help to better comprehend mechanisms. The polymorphism KIR2DL2/2DL3 has shown influence binding specificity affinity HLA‐C1 ligands. present study aims investigate distribution in a southern Chinese population using sequence‐specific primer polymerase chain reaction...
HLA-C*03:240 differs from HLA-C*03:42 by a single nucleotide substitution that results in missense mutation Tyr 99 Cys (TAT to TGT).
HLA-A*02:431 differs from the closest allele HLA-A*02:03:01 by a nonsynonymous mutation at nucleotide 317 in exon 2.
Abstract Human natural killer (NK) cells are essential for controlling infection, cancer and fetal development. NK cell functions modulated by interactions between polymorphic inhibitory immunoglobulin-like receptors (KIR) HLA-A, -B -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand contribute to reproduction immunity. In contrast, only some HLA-A they focus By high-resolution analysis of , genes, we show that the Chinese Southern Han significantly enriched -B. This...
The novel KIR2DL1*00308 allele differs from the closest KIR2DL1*00302 by a single sense mutation.