A5037859249- Optical Imaging and Spectroscopy Techniques
- Heart Rate Variability and Autonomic Control
- Tuberculosis Research and Epidemiology
- Botulinum Toxin and Related Neurological Disorders
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Transcranial Magnetic Stimulation Studies
- Pain Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Physical Performance
- Identification and Quantification in Food
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Musculoskeletal pain and rehabilitation
- Folate and B Vitamins Research
- Thermoregulation and physiological responses
- Antibiotic Resistance in Bacteria
- Muscle metabolism and nutrition
- Bipolar Disorder and Treatment
- Bacillus and Francisella bacterial research
- Growth Hormone and Insulin-like Growth Factors
- Infrared Thermography in Medicine
- Sleep and related disorders
- Neurological disorders and treatments
Shandong Center for Disease Control and Prevention
2022-2024
Tsinghua University
2008-2020
Beijing Hua Xin Hospital
2016-2019
Institute of Infection and Immunity
2017
Harbin Medical University
2014-2017
Neuroscience Institute
2017
Fudan University
2012
Beijing Shijingshan Hospital
2009
Indiana University Bloomington
1998
Background. The Mycobacterium tuberculosis Beijing strains are widespread globally. We aimed to determine whether in China more likely than other spread, and they become drug resistant. also sought different sublineages have distinct phenotypic characteristics. Methods. conducted a population-based molecular epidemiologic study 6 provinces from 2009 2010. analyzed data specimens culture-confirmed pulmonary patients. Each patient's isolate was genotyped using 16-loci variable number of tandem...
Cavities are important in clinical diagnosis of pulmonary tuberculosis (TB) infected by Mycobacterium tuberculosis. Although microRNAs (miRNAs) play a vital role the regulation inflammation, relation between plasma miRNA and with cavity remains unknown. In this study, samples were derived from 89 cavitary (CP-TB) patients, non-cavitary (NCP-TB) patients 95 healthy controls. Groups matched for age gender. screening phase, Illumina high-throughput sequencing technology was employed to analyze...
Background/Objective . Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major disorder (MDD) and MD. Methods The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented 30 MDD, MD, healthy controls (HCs) using verbal fluency task (VFT) near-infrared spectroscopy (NIRS). Results observed a significant Oxy-Hb left...
Purpose: Daytime complaints such as memory and attention deficits failure to accomplish daily tasks are common in insomnia patients. However, objective psychological tests detect cognitive impairment equivocal. Neural function associated with performance may explain the discrepancy. The aim of this study was investigate hemodynamic response patterns patients chronic disorder (CID) using noninvasive low-cost functional neuroimaging technique multichannel near-infrared spectroscopy (NIRS)...
Abstract The dopamine D3 receptor has been implicated in the pathophysiology of schizophrenia (SZ). A glycine‐to‐serine polymorphism at codon 9 gene (DRD3), rs6280, widely studied for its association with SZ, but conflicting results. Altered levels DRD3 mRNA have also reported SZ compared normal controls. Moreover, it suggested that is subject to recent positive selection European populations. To explore potential role from these various aspects, we conducted a threefold study. First, tested...
, a Gram-positive conditional pathogen of
The blood-derived RNA levels of the adenylosuccinate synthase (ADSS) and ataxia telangiectasia mutated (ATM) genes were found to be down- up-regulated, respectively, in schizophrenics compared with controls, ADSS ATM among eight biomarker discriminate from normal controls. catalyzes first committed step AMP synthesis, while kinase serves as a key signal transducer DNA double-strand breaks response pathway. It remains unclear whether these changes result mutations or polymorphisms two...
Background The worldwide emergence and diffusion of extended-spectrum β-lactamase- K. pneumoniae (ESBL-KP) is particular concern. Although ESBL-KP can inhabit the human gut asymptomatically, colonization with associated an increased risk infection mortality. In this study, we investigated prevalence characteristics in fecal samples from healthy persons 12 villages Shandong Province, China. Methods Screening for was performed by selective cultivation. bacterial species were identified using...
Blepharospasm (BSP) has a morbidity of 16 to 133 per million and is characterized by orbicularis oculi spasms. BSP can severely impact daily life. However, date, its pathophysiology not been clearly demonstrated. Near-infrared spectroscopy (NIRS) portable, non-invasive, high time resolution apparatus used measure cerebral blood flow. This study aimed investigate the hemodynamic response patterns patients determine whether alone be an attributional factor influence function prefrontal area...
Objective Exploring the characteristics of prefrontal cortex activation in patients major depressive disorder (MDD) combined with anxiety and obsession through functional near-infrared spectroscopy (fNIRS). Methods Prefrontal hemoglobin concentration exchange 30 MDD was detected by fNIRS under voice fluency task(VFT), then psychological assessment made using Hanmilton Depression Scale(HAMD), Hamilton Anxiety Scale(HAMA) Symptom Checklist 90(SCL-90). The scores were compared....
Objective To construct a prokaryotic expression vector carrying Mycobacterium tuberculosis(MTB)Rv0073 gene and express the recombinant protein in Escherichia coli(E.coli). Methods The Rv0073 from MTB H37Rv strain was amplified by polymerase chain reaction (PCR) cloned into plasmid pET26b(+ ). Then, E.coli BL21 transformed with plasmid. The induced using Isopropyl β-D-1-thiogalactopyranoside (IPTG)at 25 ℃, 28 30 34 ℃ 37 respectively. IPTG induction for 2 h, 4 h 7 also examined....
Qbjective To investigate the effects on mycobacterial interspersed repetitive units-variable-number tandem repeat(MIRU-VNTR)genotyping of loci with same allelic diversity in Mycobacterium tuberculosis Beijing genotype strains. Method R 2.9.1 software was used to construct phylogenetic tree based two 9 and 12 MIRU-VNTR combinations which have except MIRU40/MIRU16 MIRU39/MIRU31 respectively.The Hunter-Gaston index, cluster rate characteristic were analyzed...
<b><i>Objective:</i></b> To determine whether orbitofrontal cortex (OFC) function improves with blepharospasm (BSP) symptom remission using a verbal fluency task and near-infrared spectroscopy (NIRS). <b><i>Methods:</i></b> Nineteen BSP patients 9 healthy controls (HCs) matched by gender education were examined NIRS. The divided into 2 groups based on the onset or of symptoms. A covariance analysis was conducted to analyze differences among 3...
Objective To explore the characteristics of prefrontal cortex activation by near-infrared spectroscopy (NIRS) in depressed patients who also had suicide ideation or committed suicide. Methods Total 23 suffered major depression disorder (MDD) complicated with behavior (suicide group), 28 MDD bearing without and 26 healthy controls, matched gender, age, education, were tested category verbal fluency task (VFT). During task, 52-channel FOIRE-3000 Shimadzu was used to collect relative...
38 Insulin-like growth factor-1(IGF-1) has strong anabolic effects and blood levels are inversely correlated with abdominal visceral fat (AVF) positively free mass (FFM). We investigated the relationships between a DNA microsatellite polymorphism in promoter region of IGF-1 gene body composition phenotypes at baseline (B) following 20-wk endurance training program (Δ) HERITAGE Family Study. B Δ (FM), FFM AVF were measured on 530 Caucasian subjects (98 families; 194 parents 336 adult...