A5101513576- Wastewater Treatment and Nitrogen Removal
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Respiratory viral infections research
- Nerve injury and regeneration
- Heavy metals in environment
- Microbial Fuel Cells and Bioremediation
- MicroRNA in disease regulation
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Pneumonia and Respiratory Infections
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Microbial Community Ecology and Physiology
- SARS-CoV-2 and COVID-19 Research
- Water Treatment and Disinfection
- Neuroscience and Neuropharmacology Research
- Microbial infections and disease research
- interferon and immune responses
- Asthma and respiratory diseases
- Water Quality Monitoring and Analysis
- Cannabis and Cannabinoid Research
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
Anhui University of Traditional Chinese Medicine
2025
Medtronic (China)
2024
Southwest University
2024
Harbin Medical University
2013-2023
Second Affiliated Hospital of Harbin Medical University
2013-2023
Capital Institute of Pediatrics
2002-2023
X-Fab (Germany)
2021
Ninghai First Hospital Medicare and Health Group
2020
Center for Clinical Research (United States)
2018
Shenyang Jianzhu University
2010-2017
Although previous studies have reported the use of metabolomics for infectious diseases, little is known about potential function plasma metabolites in children infected with Mycoplasma pneumoniae (MP). Here, a combination liquid chromatography-quadrupole time-of-flight mass spectrometry and random forest-based classification model was used to provide broader range applications MP diagnosis. In training cohort, from 63 pneumonia (MPPs), 37 healthy controls (HC) 29 disease (IDC) collected....
To control the ongoing coronavirus disease-2019 (COVID-19) pandemic, CoronaVac (Sinovac), an inactivated vaccine, has been granted emergency use authorization by many countries. However, underlying mechanisms of COVID-19 vaccine-induced immune response remain unclear, and little is known about its features compared to (Severe acute respiratory syndrome 2) SARS-CoV-2 infection. Here, we implemented single-cell RNA sequencing (scRNA-seq) profile longitudinally collected PBMCs (peripheral blood...
Community-acquired pneumonia (CAP) is the primary cause of death for children under five years age globally. Hence, it essential to investigate new early biomarkers and potential mechanisms involved in disease severity.Proteomics combined with metabolomics was performed identify suitable diagnosis severe CAP. In training cohort, proteomics were on serum samples obtained from 20 CAPs (S-CAPs), 15 non-severe (NS-CAPs) healthy controls (CONs). verification selected their combinations validated...
J. Neurochem. (2012) 120 , 842–849. Abstract Endocannabinoids are neuromodulatory lipids that mediate the central and peripheral neural functions. have demonstrated their anti‐proliferative, anti‐angiogenic pro‐apoptotic properties in a series of studies. In present study, we investigated levels two major endocannabinoids, anandamide 2‐arachidonylglycerol (2‐AG), receptors, CB1 CB2, human low grade glioma (WHO I‐II) tissues, high III‐IV) non‐tumor brain tissue controls. We also measured...
Cavities are important in clinical diagnosis of pulmonary tuberculosis (TB) infected by Mycobacterium tuberculosis. Although microRNAs (miRNAs) play a vital role the regulation inflammation, relation between plasma miRNA and with cavity remains unknown. In this study, samples were derived from 89 cavitary (CP-TB) patients, non-cavitary (NCP-TB) patients 95 healthy controls. Groups matched for age gender. screening phase, Illumina high-throughput sequencing technology was employed to analyze...
CoronaVac (Sinovac), an inactivated vaccine for SARS-CoV-2, has been widely used immunization. However, analysis of the underlying molecular mechanisms driving CoronaVac-induced immunity is still limited. Here, we applied a systems biology approach to understand behind adaptive immune response in cohort 50 volunteers immunized with 2 doses CoronaVac. Vaccination led integrated that included several effector arms system including specific IgM/IgG, humoral and other response, as well innate...
Wilson's disease (WD) liver damage is caused by abnormal copper deposition in the liver. Whether degree of hepatic impairment correlates with severity involvement on ultrasound imaging remains unclear. This study aimed to categorize echo patterns WD according B-ultrasound and correlated injury different based Transient elastography (TE) Sound Touch Viscoelastography (STVi). A retrospective was conducted 106 patients. consistency analysis performed stiffness measurement (LSM) through TE STVi....
Two highly heavy metal resistant indigenous bacterial strains, DX-T3-01 and DX-T3-03, were isolated from the biggest tailing in Asia-Dexing copper mine 4# tailing. The strain exhibited high tolerance to cadmium: 10 mM Cd2+ with yeast tryptophan peptone glucose (YTPG) agar plates 18 liquid medium. DX-T3-03 was zinc could endure 35 Zn2+ with YTPG 40 They also showed other metals, such as copper, lead nickel. morphology, physiological biochemical characteristics of two strains examined by...
Summary Purpose: Genetically epileptic WAG/Rij rats develop spontaneous absence‐like seizures after 3 months of age. We used to examine whether absence are associated with changes in the expression type‐1 cannabinoid (CB 1 ) receptors. Methods: Receptor was examined by situ hybridization and western blot analysis various brain regions “presymptomatic” 2‐month old “symptomatic” 8‐month‐old relative age‐matched nonepileptic control rats. Furthermore, we pharmacologic activation CB receptor...
N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme involved in biological deactivation of N-palmitoylethanolamide (PEA), which exerts anti-inflammatory and analgesic effects through the activation nuclear receptor peroxisome proliferator-activated receptor-alpha (PPAR-α). To develop selective potent NAAA inhibitors, we designed synthesized series derivatives 1-pentadecanyl-carbonyl pyrrolidine (compound 1), general inhibitor. Structure activity relationship (SAR)...
Celastrol, a major active ingredient of Chinese herb Tripterygium wilfordii Hook. f. (thunder god vine), has exhibited broad spectrum pharmacological activities, including anti-inflammation, anti-cancer and immunosuppression. In the present study, we used animal models inflammatory pain neuropathic pain, generated by carrageenan injection spared nerve injury (SNI), respectively, to evaluate effect celastrol address mechanisms underlying processing. Intraperitoneal (i.p.) produced...
Dental pulp stem cells (DPSCs) are considered as an ideal cell source for the treatment of neurological diseases. In this study, we evaluated therapeutic potency DPSCs and brain-derived neurotrophic factor (BDNF) in focal cerebral ischemia using animal models. Following middle artery occlusion (MCAO), rats were randomized into four groups: BDNF, DPSCs, DPSCs+BDNF controls injected with saline. transplanted BDNF was group via tail vein. The fate rat brains immunofluorescence,...
Background/Aims: Ischemic stroke is a major cause of disability and mortality worldwide, while effective restorative treatments are limited at present. Stem cell transplantation holds therapeutic potential for ischemic vascular diseases may provide an opportunity neural regeneration. Dental pulp stem cells (DPSCs) origin from crest have neuro-ectodermal features including proliferation multilineage differentiation potentials. Methods: The rat model middle cerebral artery occlusion (MCAO) was...
Dental pulp stem cells are dental pulp-derived mesenchymal that originate from the neural crest. They exhibit greater potential for treatment of nervous system diseases than other types because their neurogenic differentiation capability and ability to secrete multiple neurotrophic factors. Few studies have reported Alzheimer’s disease using cells. Rat models were established by injecting amyloid-β1–42 into hippocampus. Fourteen days later, 5 × 106 injected Immunohistochemistry western blot...
// Deling Luo 1 and Jin Fu Department of Neurology, The Second Affiliated Hospital Harbin Medical University, Nangang District, 150086, China Correspondence to: Fu, email: fujindoctor@163.com Keywords: miRNAs; multiple sclerosis; peripheral blood mono-nuclear cells; susceptibility gene; therapy Received: February 18, 2017 Accepted: December Published: January 02, 2018 ABSTRACT Multiple sclerosis is a chronic autoimmune disorder the central nervous system. In MS, genetic high currently there...
Spinal cord injury (SCI) is one of the most severe central nervous system injuries. Currently, transplanting bone marrow mesenchymal stem cells (BMSCs) considered a therapeutic option for SCI. Tanshinone IIA (TIIA) extracts obtained from Salvia miltiorrhiza Bunge, which has been shown to have some protective effects against The present research was aimed explore whether TIIA would influence fate transplanted BMSCs in rat model SCI, especially with regard their differentiation into neuronal...
Hair follicle stem cells (HFSCs) are considered as a promising cell type in the transplantation treatment of neurological diseases because their rich sources, easy access, and same ectoderm source nervous system. Hepatocyte growth factor (HGF) is pleiotropic cytokine that shows neuroprotective function ischemic stroke. Here we assessed therapeutic effects HFSCs on stroke injury synthetic effect HGF along with HFSCs.Rat were intravenously transplanted into middle cerebral artery...
Several studies demonstrate that neurogenesis may be induced or activated following vascular insults, which important for neuronal regeneration and functional recovery. Understanding the cellular mechanism underlying stroke-associated is of neurobiological as well neurological/clinical relevance. The present study attempted to explore potential homing early development transplanted bone marrow stem cells in mouse forebrain after focal occlusion middle cerebral artery, an experimental model...
Bone marrow mononuclear cell (BMMC) transplantation is a promising therapy for cerebral ischemia; however, little known if its therapeutic efficacy may be improved by co-administration of potential modulatory factors in vivo. To explore this possibility, the present study examined effect BMMCs and G-CSF on proliferation, early neuronal development neurological function recovery experimental ischemia relative to controls that received neither treatment.Ischemia/infarct area was significantly...