A5100358957- Mesenchymal stem cell research
- NF-κB Signaling Pathways
- Pancreatic function and diabetes
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Natural product bioactivities and synthesis
- Toxoplasma gondii Research Studies
- Liver Disease Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Metabolism, Diabetes, and Cancer
- Advanced Drug Delivery Systems
- Mycotoxins in Agriculture and Food
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Parasitic Infections and Diagnostics
- Alcohol Consumption and Health Effects
- Neurological Disease Mechanisms and Treatments
- Nanocomposite Films for Food Packaging
- Medicinal Plant Extracts Effects
- Gastrointestinal motility and disorders
- Cytomegalovirus and herpesvirus research
Yanbian University
2014-2024
Fudan University
2013-2024
Jiangxi University of Traditional Chinese Medicine
2024
Gansu Agricultural University
2023-2024
Luye Pharma (China)
2014-2023
Affiliated Hospital of North Sichuan Medical College
2023
Harbin Medical University
2010-2022
Kunming Institute of Botany
2022
Chinese Academy of Sciences
2021-2022
Kunming Medical University
2021-2022
Taraxasterol, a pentacyclic‐triterpene compound, is one of the main active components isolated from traditional Chinese medicinal herb Taraxacum . The objective this study to evaluate protective effects taraxasterol and its possible underlying mechanisms against ethanol‐induced liver injury in mice. ICR mice were fed with Lieber‐DeCarli diet containing 5% ethanol for 10 d then challenged single dose 20% (5 g/kg BW) by intragastric administration. intragastrically treated daily (2.5, 5,...
Aflatoxin B1 (AFB1) is the most dangerous and abundant mycotoxin, which toxic to almost all animals, poultry more sensitive AFB1 toxicity. Ingesting AFB1-contaminated feed can cause significant liver damage brings serious harm poultry, greatly restricts development of industry. The present research was implemented explore intervention effect its mechanism taraxasterol on induced by in broiler chickens. model chickens established feeding 0.5 mg/kg feed, (25, 50 100 BW, respectively) given...
This study aimed to evaluate the diagnostic value of acoustic radiation force impulse (ARFI) elasticity imaging for differentiating between benign and malignant thyroid lesions.Hospitalized patients needing surgery were evaluated. After routine sonography, underwent ARFI imaging. Virtual Touch tissue (VTI) quantification (VTQ; Siemens Medical Solutions, Mountain View, CA) used qualitatively quantitatively analyze hardness nodules. For statistical analysis, Student t test, analysis variance,...
Abstract Lipopolysaccharide (LPS) can induce mouse macrophages to produce a number of cytokines and other inflammatory mediators. Immunopharmacological studies provide new information on the immunomodulatory activities some drugs, including their effect cytokine productions. For this reason, we first investigated efficacy avermectin levels induced by LPS in vitro, found that significantly regulate tumor necrosis factor alpha, interleukin (IL)‐1β IL‐10, but has no significant IL‐6. We further...
Abstract Hepatocyte growth factor (HGF) and glial cell line‐derived neurotrophic (GDNF) are strong factors. However, their potentials in neurogenesis, angiogenesis, synaptogenesis, antifibrosis have not been compared. Therefore, we investigated these effects of HGF GDNF cerebral ischemia the rat. Wistar rats were subjected to 90 min transient middle artery occlusion (tMCAO). Immediately after reperfusion, or was given by topical application. BrdU injected intraperitoneally twice daily 1, 2,...
The present work was performed aiming to develop a new solid self-emulsifying system (SMEDDS) for poorly water-soluble drug Lornoxicam and evaluate the bioavailability in Wister rats by oral gavage. Liquid SMEDDS of formulated with Labrafil M 1944 CS as oil phase, Kolliphor HS 15 surfactant Transcutol HP cosurfactant after screening various vehicles. microemulsion selected from phase diagram optimized central composite design (CCD) response surface method transformed into solid-SMEDDS...
Immune hepatic injury is a liver disease closely related to an immune imbalance of T cells and macrophages. Our previous series studies have demonstrated that taraxasterol isolated from Taraxacum possesses great anti-inflammatory immunomodulatory effects in vivo vitro. In this study, we explored the preventive its underlying mechanisms on concanavalin A (Con A)-induced acute mice. It was found treatment with significantly decreased Con A-induced increase index, serum alanine aminotransferase...
Astragali Radix has long been used to improve immune function in traditional Chinese medicine. However, its main active components and potential immunomodulatory or anti-inflammatory activities have not elucidated. In the present study, of total flavonoids Astragalus (TFA) isolated from were evaluated by using vivo animal models vitro cell models.The Immunomodulatory TFA assessed measuring macrophage phagocytic index, delayed type hypersensitivity, serum hemolysin level organ index mice, ear...
Background: Rotigotine is a potent and selective D 1 , 2 3 dopaminergic receptor agonist. Due to an extensive first-pass effect, it has very low oral bioavailability (approximately 0.5% in rats). Purpose: The present investigation aimed develop microemulsion-based hydrogel for transdermal rotigotine delivery with lower application site reactions. Methods: Pseudoternary phase diagrams were constructed determine the region of oil water (o/w)-type microemulsion. Central composite design was...
Bergenin (BGN) is a C-glycoside of 4-O-methylgallic acid with anti-inflammatory, antioxidant, and tissue-repairing abilities. Here, we probed the roles mechanisms BGN in ischemic stroke-mediated cerebral injury.The middle artery occlusion (MCAO) model was established mice, which were injected intraperitoneally varying concentrations (10, 20, 40 mg/kg). The modified neurological severity score (mNSS) water maze experiment adopted to evaluate mice's neural functions (movement memory). brain...
Taraxasterol, a pentacyclic-triterpene, was isolated from the Chinese medicinal herb Taraxacum officinale. In present study, we investigated protective effect of taraxasterol on murine model endotoxic shock and mechanism its action. Mice were treated with 2.5, 5 10 mg/kg prior to lethal dose lipopolysaccharide (LPS) challenge. Survival mice monitored twice day for 7 days. To further understand mechanism, serum levels inflammatory cytokine tumor necrosis factor-α (TNF-α), interferon-γ...
Background/Aims: Ischemic stroke is a major cause of disability and mortality worldwide, while effective restorative treatments are limited at present. Stem cell transplantation holds therapeutic potential for ischemic vascular diseases may provide an opportunity neural regeneration. Dental pulp stem cells (DPSCs) origin from crest have neuro-ectodermal features including proliferation multilineage differentiation potentials. Methods: The rat model middle cerebral artery occlusion (MCAO) was...
The brain is now recognized as an insulin-sensitive tissue; however, the role of changing insulin concentrations in peripheral circulation gene expression largely unknown. Here, we performed a hyperinsulinemic-euglycemic clamp on 3-month-old male C57BL/6 mice for 3 h. We show that, comparison with results saline-infused controls, increases within physiological range regulate broad network genes brain. Insulin regulates distinct pathways hypothalamus (HTM), hippocampus, and nucleus accumbens....