A5024273045- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Immune Response and Inflammation
- Cancer Research and Treatments
- NF-κB Signaling Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Natural product bioactivities and synthesis
- Angiogenesis and VEGF in Cancer
- Parasites and Host Interactions
- Ion channel regulation and function
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Helminth infection and control
- Spinal Cord Injury Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Essential Oils and Antimicrobial Activity
- Ion Transport and Channel Regulation
- Thermal Regulation in Medicine
- Seed and Plant Biochemistry
- interferon and immune responses
- Pain Mechanisms and Treatments
- Esophageal Cancer Research and Treatment
Shaanxi University of Chinese Medicine
2025
Jilin University
2008-2024
Ministry of Agriculture and Rural Affairs
2021-2024
Chengdu University
2021-2024
State Key Laboratory on Integrated Optoelectronics
2024
Shaanxi Provincial People's Hospital
2023
Shanxi Medical University
2018-2023
Soochow University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2023
Northeast Agricultural University
2023
Abstract Lipopolysaccharide (LPS) can induce mouse macrophages to produce a number of cytokines and other inflammatory mediators. Immunopharmacological studies provide new information on the immunomodulatory activities some drugs, including their effect cytokine productions. For this reason, we first investigated efficacy avermectin levels induced by LPS in vitro, found that significantly regulate tumor necrosis factor alpha, interleukin (IL)‐1β IL‐10, but has no significant IL‐6. We further...
Diabetic encephalopathy (DE) is one of the severe complications in patients with diabetes mellitus. Paeonol, an active compound isolated from root bark Paeonia suffruticosa, has significant antidiabetic activity vivo. However, its underlying beneficial effects on DE were unclear. In present study, protective paeonol was evaluated streptozotocin (STZ)-induced diabetic rats. Paeonol at 50 and 100 mg/kg significantly increased body weight decreased blood glucose levels, glycosylated serum...
Abstract Posttraumatic growth (PTG) is defined as positive psychological change in the wake of highly challenging circumstances. Healthcare workers particular are more vulnerable to stressors and trauma than general population. The current study examined use effectiveness a novel intervention based on Chinese traditional culture improve PTG hospital healthcare workers. was provided 579 at hospitals Guilin, Shenzhen Xiangtan. Scores Growth Inventory (PTGI) its subscales were significantly...
Salidroside is a major component extracted from Rhodiola rosea. In this study, we investigated protective effects of salidroside on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. the mouse model, found that pretreatment with single 120 mg/kg dose prior to administration intratracheal LPS induced significant decrease W/D ratio and myeloperoxidase activity lung, reduction protein concentration, number total cells, neutrophils macrophages bronchoalveolar lavage fluid....
Esculin is a derivative of coumarin, which also an active ingredient ash bark, and has antibacterial, anti-inflammatory, anti‑allergy skin protective effects. The underlying mechanism effects esculin on cognitive impairment in experimental diabetic nephropathy (DN) was investigated the present study. Male C57BL/6J 6‑week‑old mice were injected intravenously with single dose streptozotocin (STZ; 30 mg/kg). At 2 weeks after STZ injection, received intravenous injection 5, 10 or 20 mg/kg for...
The prevalence of lipid metabolism diseases, mainly obesity, fatty liver, and hyperlipidemia, is increasing in the world. Tartary buckwheat a kind medicinal edible crop, clinical experiments have also confirmed that dietary can effectively regulate disorders. protein (TBP), as main active ingredient buckwheat, has an effect blood reduction been widely reported. In this paper, we investigated constituents TBP then evaluated hypolipidemic hyperlipidemia rats. Male Sprague-Dawley rats were fed...
Background: Glioblastoma (GBM) is considered a clinically refractory malignant tumor due to its high recurrence and malignancy, invasiveness, poor prognosis. The ethnomedicine Huafengdan (HFD) prepared using several Chinese herbs by complex fermentation process that has long history. Previous studies have reported the inhibitory effect of HFD on GBM both in vitro vivo; however, mechanism action unclear. Methods: effects growth, migration, invasion cells were determined MTT assay, EdU...
Endothelial cells (EC) are sensitive to changes in the microenvironment, including hypoxia and ischemia. Disruption of microtubular network has been reported cases However, signaling pathways involved hypoxia-induced disruption unknown. The purpose this study was investigate molecular mechanisms disassembly human umbilical vein endothelial (HUVECs). HUVECs were cultured under normoxic or hypoxic conditions pretreated with without colchicine paclitaxel. MTT assay, Transwell trans-endothelial...
The objective of this study was to evaluate the immunomodulatory effects cinobufagin (CBG) isolated from Chan Su (Venenum Bufonis) in vitro. In paper, our results show that CBG significantly stimulated cell proliferation splenocytes and peritoneal macrophages (PMΦ) markedly enhanced phagocytic activation PMΦ. also increased CD4(+)CD8(+) double-positive T-cell populations percentage S-phase cells splenic lymphocytes. levels several Th1 cytokines, including interferon-γ tumor necrosis...
Abstract Bridging strategies are essential for spinal cord repair in order to provide a physical substrate allowing axons grow across the site of lesions. In this study, we have evaluated therapeutic effects adding amniotic epithelial cells unidirectionally oriented acellular muscle scaffold and compared with effect alone. Chemically extracted muscles, or without cells, were implanted into lateral hemisected adult rat thoracic cord. Control rats similarly injured. After 4 weeks, scaffolds...
The aim of this study was to identify the active anti-ischemic components Pterocypsela elata (P. elata) using a network pharmacology approach construct an effective component anti-cerebral ischemic target and systematically analyze medicinal material.Pharmacological studies have shown that P. has obvious effect against cerebral ischemia. To potential targets, 14 were docked each structural element targets in DRAR-CPI database by reverse docking technology. We then compared identified with...
Abstract Many traditional Chinese medicines have been used as immunomodulators that act either immunosuppressants or immunostimulators. Recently, our lab successfully isolated a monomer telocinobufagin (TCB) from the chloroform extract of Chan Su ( Venenum Bufonis ). In present paper, we evaluated immunomodulatory effects this compound in vitro. We found TCB significantly stimulates splenocyte proliferation when administered alone combination with polyclonal T‐cell mitogens concanavalin A...