A5005767728- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Calpain Protease Function and Regulation
- Inflammasome and immune disorders
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Medicinal Plant Pharmacodynamics Research
- Inflammation biomarkers and pathways
- Biological and pharmacological studies of plants
- Barrier Structure and Function Studies
- Traditional Chinese Medicine Studies
- Mitochondrial Function and Pathology
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Oral microbiology and periodontitis research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and biosynthesis
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Adenosine and Purinergic Signaling
- Fatty Acid Research and Health
- Circular RNAs in diseases
Guiyang Medical University
2019-2025
Guizhou Provincial People's Hospital
2021
Stomatology Hospital
2012
Tianjin Medical University
2012
Douglas College
2010
Douglas Mental Health University Institute
2010
Background: Glioblastoma (GBM) is considered a clinically refractory malignant tumor due to its high recurrence and malignancy, invasiveness, poor prognosis. The ethnomedicine Huafengdan (HFD) prepared using several Chinese herbs by complex fermentation process that has long history. Previous studies have reported the inhibitory effect of HFD on GBM both in vitro vivo; however, mechanism action unclear. Methods: effects growth, migration, invasion cells were determined MTT assay, EdU...
Cisplatin resistance is a major cause of poor prognosis in patients with cervical cancer. Dysregulation long noncoding RNAs (lncRNAs) plays key role chemoresistance. Our results reveal that the lncRNA UCA1 upregulated cisplatin (DDP)-resistant cancer tissues and HeLa cells. Mechanistically, acts as sponge for miR-195-5p, targeting IKBKB. enhances proliferation, migration, invasion while reducing apoptosis DDP-resistant cells via miR-195-5p/IKBKB axis. Additionally, upregulates BNIP3Δex2...
Abstract Background Ischemic cerebrovascular disease (ICVD) is one of three fatal diseases in humans, along with heart and malignant tumors. Cerebral ischemia/reperfusion injury (CI/RI) the primary cause ICVD. Recently, seipin was reported to be crucial for lipid droplet formation, hepatic steatosis, axonal atrophy. However, function mechanism CI/RI has not been explicitly stated. Methods Oxygen–glucose deprivation/reoxygenation (OGD/R) hippocampal neuron cell line (HT‐22) middle cerebral...
Intracarotid cold saline infusion (ICSI) brings about neuroprotective effects in ischemic stroke. However, the involvement of serum and glucocorticoid‑regulated kinase 1 (SGK1) underlying mechanism ICSI is not fully understood; therefore, we used rat middle cerebral artery occlusion (MCAO) model to investigate on stroke rats, as well SGK1 these effects. decreased infarct size brain swelling, determined by 2,3,5‑triphenyltetrazolium chloride staining dry‑wet weight method, respectively. The...
Objective To investigate fluoride-induced inflammation and nuclear factor-κB (NF-κB) signaling pathway in cultured human acute monocytic leukemia cells (THP-1). Methods In vitro THP-1 were used as a model of microglia. After with different concentrations [0 (negative control group), 10, 50, 100, 500, 1 000 5 μmol/L] sodium fluoride (NaF) for 48 h, the survival was detected by CCK8. divided into 3 groups: group, low dose high groups according to results CCK8 assay, then treated (0,...
In neurodegenerative diseases, the activation of microglia and ensuing neuroinflammation are pivotal in regulating disease progression. Attenuating inflammation induced by microglial cells is considered a key strategy for slowing progression diseases. γ‐glutamylcysteine (γ‐GC) has exhibited significant antioxidative anti‐inflammatory effects; nevertheless, its potential role modulating neuroinflammatory responses remains incompletely explored. The current investigation aimed to establish...
Accurate diagnosis of major depressive disorder (MDD) remains difficult, and one the key challenges in diagnosing MDD is lack reliable diagnostic biomarkers. The objective this study was to explore gene networks identify potential biomarkers for MDD.In present study, we performed a comprehensive analysis mRNA expression profiles using blood samples four patients with controls by RNA sequencing. Differentially expressed genes (DEGs) were screened, functional pathway enrichment analyses...
Objective To explore the role of apoptosis-inducing factors (AIF) mediated non-apoptosis classic pathway involved in neuron apoptosis rats with chronic fluorosis. Methods Sixty Sprague Dawley (SD) (body weight 100-120 g) were divided into two groups (30 each group, half male and female) by random number table according to body weight. Control group was fed tap water fluoride content< 0.5 mg/L fluorine content 50.0 mg/L. Both standard food mg/kg. After 10 months, all animals sacrificed...
Unscheduled reinitiation of cell cycle in post-mitotic cells (such as neurons) preceds their death some paradigms neurodegeneration, including Alzheimer's disease (AD). We used a transgenic TgCRND8 mouse model to explore whether induction the molecule, cylcin D1, may serve an early marker AD-associated neuronal death. Cyclin D1 expression was analyzed soluble protein extracts obtained from vulnerable (cortex and hippocampus) relatively spared (striatum cerebellum) brain regions coming 4, 6 9...
Objective To explore the relationship between diabetic nephropathy(DN) and periodontal disease.Methods 200 new hospitalized patients with type 2 diabetes were enrolled.Subjects further divided into three groups according to level of microalbuminuria(MAU):group A (normal albuminuria group):MAU ＜30 mg/24 h,group B (early-stage DN 30 ～300 C (clinical ＞300 h.The clinical data kidney function markers including serum creatinine (Scr),blood urea nitrogen(BUN) collected,estimated glomerular...