A5011731095- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Nanoplatforms for cancer theranostics
- Characterization and Applications of Magnetic Nanoparticles
- Advanced X-ray and CT Imaging
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Lung Cancer Diagnosis and Treatment
- Acute Kidney Injury Research
- Liver physiology and pathology
- Magnetic Properties of Alloys
- Organ Transplantation Techniques and Outcomes
- Micro and Nano Robotics
- Virus-based gene therapy research
- Angiogenesis and VEGF in Cancer
Soochow University
2011-2025
First Affiliated Hospital of Soochow University
2011-2025
Soochow University
2020-2024
Second Affiliated Hospital of Soochow University
2014
BackgroundAccurate lymph nodes (LNs) assessment is important for rectal cancer (RC) staging in multiparametric magnetic resonance imaging (mpMRI). However, it incredibly time-consumming to identify all the LNs scan region. This study aims develop and validate a deep-learning-based, fully-automated node detection segmentation (auto-LNDS) model based on mpMRI.MethodsIn total, 5789 annotated (diameter ≥ 3 mm) mpMRI from 293 patients with RC single center were enrolled. Fused T2-weighted images...
Abstract Hyperthermia induced by the alternating magnetic field (AMF) to heat nanomaterials localized within tumor has attracted wide attention due its ability in effective ablation, low side effects, and deep tissue penetration. However, rather strong AMFs are often needed realize hyperthermia of tumors. Herein, it is discovered that nonmagnetic gallium–indium liquid metal (GaIn LM) above certain sizes prepared shearing force could be effectively heated up under AMF with a intensity owing...
Magnetic hyperthermia therapy (MHT) is able to ablate tumors using an alternating magnetic field (AMF) heat up magnetocaloric agents (e.g. nanoparticles) administered into the tumors. For clinical applications, there still a demand find new with strong AMF-induced heating performance and excellent biocompatibility. As kind of biocompatible biodegradable material, magnesium (Mg) its alloys have been extensively used in clinic as implant metal. Herein, we discovered that eddy thermal effect...
Purpose: To compare the safety and efficacy of hepatic arterial infusion chemotherapy followed by transarterial embolization (HAIC+TAE) to chemoembolization (TACE) for treatment unresectable hepatocellular carcinoma (uHCC). Materials methods: The clinical data patients who received HAIC+TAE or TACE between April 2020 2022 was collected. Propensity score-matching used balance baseline characteristics two groups. Tumor response according mRECIST, median time progression (TTP) overall survival...
Objective: To compare the outcomes of transarterial chemoembolization (TACE) combined with sorafenib versus TACE alone for treating patients unresectable hepatocellular carcinoma (HCC).Methods: This retrospective analysis included all receiving either plus therapy or HCC between February 2008 and August 2015 at First Affiliated Hospital Soochow University, China.Propensity score matching (PSM) was carried out to reduce bias due confounding variables.The primary outcome overall survival (OS),...
Bioinformatics provides a valuable tool to explore the molecular mechanisms underlying pathogenesis of hepatocellular carcinoma (HCC). To improve prognosis patients, identification robust biomarkers associated with pathogenic pathways HCC remains an urgent research priority.We employed Robust Rank Aggregation method integrate nine qualified datasets from Gene Expression Omnibus. A set differentially expressed genes (DEGs) between tumor and normal tissue samples were screened. Weighted gene...
Transarterial chemoembolization (TACE) is recommended as the first-line approach for intermediate hepatocellular carcinoma (HCC), and it most widely applied method advanced HCC in real-world clinical practice.[1,2] According to China Liver Cancer (CNLC) staging system, TACE therapy stages IIb IIIa, while also a major Ib, IIa, IIIb.[3] Despite its confirmed treatment efficacy safety, repeated sometimes unbeneficial some patients due high heterogenicity of HCC, manifesting liver function...
Abstract Background To detect the right atrial (RA) functions in hypertrophic cardiomyopathy (HCM) patients by using volume-derived values and two-dimensional strain. Methods Thirty-two HCM 34 age gender matched normal controls were enrolled for this study. RA measured 2D ultrasonic images. strain (S-reservoir, S-conduit, S-booster pump) rate (SR-reservoir, SR-conduit, SR-booster pump), representing reservoir, conduit booster pump functions, respectively, EchoPAC. Results Total emptying...
It is known that Lnc712 plays an important role in the pathogenesis of breast cancer. However, whether it involved hepatocellular carcinoma (HCC) remains unknown. In this study, we aimed to investigate and underlying mechanism HCC.Sixty-four HCC patients were enrolled followed up for 5 years analyze prognostic value HCC. cells transfected with expression vector, Bach-1 vector (or siRNA) miR-142-3p mimic inhibitor) explore interactions among Lnc712, Bach-1. Cell proliferation, migration,...
Epidermal growth factor-like domain-containing protein 7 (EGFL7) is an endothelial cell-derived secreted factor that regulates vascular tube formation. In human cancer, the specificity of expression lost as EGFL7 has been detected in tumor cells, addition to cells. This study evaluated intricate relationship between hypoxia-inducible 1-alpha (HIF-1α) and under both hyperoxia hypoxia states.In present study, immunohistochemical staining ELISA were applied examine relative level 182 cases...
Interferon‑stimulated gene 15 (ISG15) serves a crucial role in hepatocellular carcinoma (HCC) progression. The present study explored the effect of ISG15 knockdown on sensitivity HCC cells to norcantharidin. expression tissues and cell lines was assessed by reverse transcription‑quantitative polymerase chain reaction immunohistochemistry. Pearson's χ2 test conducted analyze correlation between clinicopathological features patients with HCC. In addition, were transfected small interfering RNA...
Long noncoding RNAs (lncRNAs) can promote hepatocellular carcinoma (HCC) initiation and progression. In this report, we examined the role of lncRNA LINC02476 in HCC.The expression levels different lncRNAs HCC were explored using TCGA database was selected for further study. The tissues determined by real-time PCR. clinicopathological characteristics patients analyzed relative to LINC02476. downregulated cells a lentiviral vector assays performed study cell growth, proliferation, invasion,...
Intracarotid cold saline infusion (ICSI) brings about neuroprotective effects in ischemic stroke. However, the involvement of serum and glucocorticoid‑regulated kinase 1 (SGK1) underlying mechanism ICSI is not fully understood; therefore, we used rat middle cerebral artery occlusion (MCAO) model to investigate on stroke rats, as well SGK1 these effects. decreased infarct size brain swelling, determined by 2,3,5‑triphenyltetrazolium chloride staining dry‑wet weight method, respectively. The...
Purpose The aim of this paper is to provide a novel, publicly available standard image dataset with useful evaluation framework for assessing nonrigid two‐/three‐dimensional (2D/3D) registration algorithms. Acquisition and validation methods A pig lung model was used obtain the dataset. Inflated different amounts oxygen, sequence 3D volume data acquired computed tomography ( CT ), which ideally simulated respiratory phases. With inflated kept in certain states, , 2D scout x‐ray were same...
Background: Epidermal growth factor-like domain multiple 7 (EGFL7), recently identified as a secreted protein regulated by oxygen exposure, plays critical role in promoting metastasis of hepatocellular carcinoma (HCC). Transcatheter arterial embolization (TAE) is widely used for treatment HCC, resulting hypoxia tumors and surrounding liver tissues. Accordingly, we proposed the hypothesis that there could be relationship between expression EGFL7 response to TAE. Materials Methods: We...
Accurate surgical planning and guidance plays an important role in successful implementation of image guided intervention. In interventional lung cancer diagnosis treatments, precise segmentation airway trees from CT images provides crucial visualization for preoperative intraoperative to avoid major trachea injury. While 3D region growing can segment main the parts tree (trachea, left right bronchus, as well bronchi), method fails at bronchiole is not robust. Mathematical morphology...