A5006528074- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Sphingolipid Metabolism and Signaling
- Synthesis and Biological Evaluation
- RNA and protein synthesis mechanisms
- Plant Disease Resistance and Genetics
- RNA Research and Splicing
- Fungal Plant Pathogen Control
- Protein Kinase Regulation and GTPase Signaling
- Toxin Mechanisms and Immunotoxins
- Radiopharmaceutical Chemistry and Applications
- Plant-Microbe Interactions and Immunity
- Synthesis and bioactivity of alkaloids
Shandong Agricultural University
2024
Wenzhou Medical University
2015-2020
First Affiliated Hospital of Wenzhou Medical University
2015-2020
Soochow University
2020
First Affiliated Hospital of Soochow University
2020
Hunan Provincial People's Hospital
2019
Juglans regia has been found to exhibit significant anticancer activity against various human cancer cell lines. This study was undertaken isolate the active chemical constituent (Juglone) and investigate its cytotoxic along with analogs different lines.Isolation of juglone, a napthoquinone, from chloroform extract root part executed by flash chromatography using silica gel as stationary phase. The isolated Juglone used starting material for further synthesis novel series triazolyl click...
Abstract We here tested expression and potential functions of circular RNA PRKCI (circPRKCI) in human glioma. Our results show that circPRKCI is upregulated glioma tissues cells, correlating with downregulation its target, microRNA-545 (miR-545). In A172 primary shRNA-mediated silencing inhibited cancer cell growth, survival, proliferation, migration. Conversely, ectopic overexpression promoted progression. miR-545 the target cells. Forced mimicked shRNA-induced actions, inhibiting survival...
Ninjurin 2 (NINJ2) is a novel adhesion molecule. Its expression and potential function in human colorectal cancer (CRC) cells are studied. We show that NINJ2 overexpressed established (HT-29) primary CRC colon tissues. level low epithelial normal shRNA or knockout (by CRSIPR/Cas9) potently inhibited cell survival proliferation, while significantly inducing apoptosis. Conversely, lentivirus-mediated overexpression promoted proliferation. co-immunoprecipitated with multiple RTKs (EGFR,...
Abstract Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related human mortality with clear need for new therapeutic intervention. GDC-0349 potent and selective ATP-competitive mTOR inhibitor. In A549 cells primary NSCLC cells, inhibited growth, proliferation, cycle progression, migration invasion, while inducing significant apoptosis activation. Although blocked Akt-mTORC1/2 activation in it also exerted cytotoxicity Akt1-knockout cells. Furthermore, restoring Akt-mTOR by...
Long non-coding RNAs (lncRNAs) serve important roles in colorectal cancer. The aim of the present study was to investigate expression and role cervical carcinoma expressed PCNA regulatory (CCEPR) lncRNA cancer progression. results demonstrated that CCEPR significantly higher tissues when compared with paired adjacent normal tissues. In addition, patients advanced (stage III/IV) than those early-stage I/II). High associated poor differentiation, clinical stage, positive lymph node metastasis...
Several studies have demonstrated that long non-coding RNA can act as crucial roles during the progression of various tumors, including prostate cancer (PCa). We aimed to determine lncRNA LINC01194(LINC01194) expression in (PCa) and examine its influence on tumor behaviors PCa cells.RT-PCR was performed LINC01194 PAX5's levels tissues cell lines. Luciferase reporter chromatin immunoprecipitation (ChIP) assays were explore whether PAX5 could activate transcription LINC01194. Cell viability,...
Long noncoding RNAs (lncRNAs) can promote hepatocellular carcinoma (HCC) initiation and progression. In this report, we examined the role of lncRNA LINC02476 in HCC.The expression levels different lncRNAs HCC were explored using TCGA database was selected for further study. The tissues determined by real-time PCR. clinicopathological characteristics patients analyzed relative to LINC02476. downregulated cells a lentiviral vector assays performed study cell growth, proliferation, invasion,...
Potato common scab, an economically important disease worldwide, is caused by pathogenic Streptomyces strains mainly through the effects of thaxtomin. The cello-oligosaccharides binding protein CebE proposed as a gateway to development scabiei. In this study, two functional encoding genes, GEO5601 and GEO7671, were identified in sp. AMCC400023. With higher affinity towards signal molecules, deletion severely impaired thaxtomin-producing capacity reduced strain’s pathogenicity....