A5101963341- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Atrial Fibrillation Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Research Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cardiac Arrhythmias and Treatments
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Colorectal Cancer Surgical Treatments
- Tryptophan and brain disorders
- Diverticular Disease and Complications
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Acute Ischemic Stroke Management
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac Valve Diseases and Treatments
Nankai University
2022-2025
King University
2025
Peking University
2023-2025
Ningbo Medical Center Lihuili Hospital
2025
Ningbo University
2025
Shanghai Chest Hospital
2018-2024
Shanghai Jiao Tong University
2018-2024
Chinese PLA General Hospital
2023-2024
Huazhong University of Science and Technology
2018-2024
Tongji Hospital
2022
Abstract Background Atrial cardiopathy is a proposed mechanism of embolic stroke undetermined source (ESUS). Left atrial (LA) strain may identify early prior to structural changes. We aim study the associations between LA strain, ESUS, and fibrillation (AF) detection in ESUS. Methods The population included patients with ESUS noncardioembolic (NCE) presenting Rhode Island Hospital Stroke Center January 2016 June 2017 who underwent transthoracic echocardiography. Speckle tracking...
BACKGROUND Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer (GC). A comprehensive review of advancements, current status, and research trends in GC immunotherapy is essential to inform future investigative efforts. AIM To delineate the trends, focal points GC. METHODS We performed bibliometric analysis 2906 articles English concerning published from 2000 December 20, 2023, indexed Web Science Core Collection. Data visualization were facilitated by CiteSpace...
Background Unlike lung adenocarcinoma, patients with advanced squamous carcinoma exhibit a low proportion of driver gene positivity, fewer effective treatment strategies available. Chemoimmunotherapy has now become the standard first-line for individuals diagnosed carcinoma. Serum metabolomics holds significant potential application in predicting responses to chemoimmunotherapy and is capable identifying validating biomarkers. The aim our study was establish model that can predict prognosis...
A significant association between high blood-based tumor mutational burden (bTMB) and improved progression-free survival (PFS) was observed in advanced non-small cell lung cancer (NSCLC) receiving atezolizumab. However, this result unrepeatable a recent prospective study. We hypothesized that there might be non-linear bTMB survival. This study used the clinical genetic data from POPLAR (n = 105, training set) OAK 324, validation trials. The assessed using restricted cubic spline (RCS)....
Primary epidermal growth factor receptor (EGFR) T790M mutation can be occasionally identified in previous untreated nonsmall cell lung cancer (NSCLC) patients. To compare clinical characteristics and outcomes patients with primary acquired EGFR mutation, we collected the data of diagnosed from 2012 to 2017 Shanghai Chest Hospital. was 61 (1.1%; 95% confidence interval (CI): 0.8%–1.3%) 5685 TKI‐naive mutant Acquired detected 98 (50.3%; 95%CI: 43.2%–57.3%) 195 TKI‐treated always coexisted...
The oral multi-targeted tyrosine kinase inhibitor (TKI) anlotinib is effective for non-small cell lung cancer (NSCLC) in clinical trials at 3rd line. However, a fraction of patients remains nonresponsive, raising the need how to identify anlotinib-responsive patients. In present study, we aimed screen potential biomarkers stratification via integrated transcriptome analysis. Comparing with anlotinib-sensitive NCI-H1975, found 1,315 genes were differentially expressed anlotinib-resistant...
Recent studies have shown that deficient mismatch repair (dMMR) rectal cancer may be related to treatment resistance, resulting in a worse prognosis than proficient MMR (pMMR) cancer. The purpose of this study was explore whether surgery plus other treatments (radiotherapy and chemotherapy) can bring more benefits these patients alone.A retrospective 168 with adenocarcinoma who underwent total mesorectal excision conducted using immunohistochemical methods determine status propensity score...
Background Co-mutations was associated with poor response to EGFR-TKIs. First-generation EGFR-TKIs combined chemotherapy reported be more effective than TKIs alone in advanced lung adenocarcinoma patients. Objective This retrospective study aimed explore whether EGFR -mutant patients co-mutations can benefit from plus chemotherapy. Patients and Methods We retrospectively collected data of 137 who underwent next-generation sequencing our hospital 2018. Among them, 96 were treated EGFR–TKIs 41...
The aim of this study is to investigate the association between tumor mutation burden (TMB) and survival in non-small cell lung cancer (NSCLC) patients with anti-programmed death protein 1 death-ligand blockade. Two retrospective cohorts Cancer Genome Atlas NSCLC data set were included study. restricted cubic spline analysis was used explore TMB survival. cutoff values for determined by X-tile software. Primary outcomes overall (OS). associations intratumor heterogeneity, number segments,...
Background: This study aimed to analyze and compare the short-term long-term outcomes of proximal gastrectomy (PG) total (TG) in patients with locally advanced gastric cancer (GC) following neoadjuvant chemotherapy (NACT). Method: A multicenter retrospective cohort propensity score matching (PSM) were employed. We examined 367 GC who received NACT followed by PG (n=164) or TG (n=203) at two Chinese medical institutions between December 2009 2022. Clinical pathological parameters,...
Abstract Objectives While the delay in adjuvant chemotherapy (AC) is known to impact colon cancer outcomes, its effect on rectal less clear. This study aims evaluate influence of AC timing survival stage II and III cancer. Methods retrospective multicenter enrolled 1,144 patients receiving following resection II–III cancers. The delayed was assessed using multivariable Cox models with restricted cubic splines logistic regression. Results Compared initiating within four weeks postsurgery,...
Abstract Background The 9th edition of the TNM Classification for lung cancer delineates M1c into two subcategories: M1c1 (Multiple extrathoracic lesions within a single organ system) and M1c2 involving multiple systems). Existing research indicates that patients with in stage exhibit superior overall survival compared to those M1c2. primary frontline therapy advanced non‐small cell (NSCLC), lacking driver gene mutations, involves use immune checkpoint inhibitors (ICIs) combined...
Background: Biomarkers for chemotherapy efficacy in non–small cell lung cancer (NSCLC) are lacking. This retrospective study assesses the association between blood-based tumor mutational burden (bTMB) and clinical benefit of chemotherapy. Methods: Clinical targeted next-generation sequencing data from OAK trial (training set; n=318) POPLAR (validation n=106) docetaxel arm were analyzed. The cutoff value bTMB outcome prediction was determined based on a time-dependent receiver operating...
Abstract Background Screening recommendations for colorectal cancer (CRC) are mainly based on family history rather than lifestyle risk factors. We aimed to assess and compare factors neoplasm (CRN) evaluate trends in detection rates during the three rounds of screening from 2012 2020 Tianjin, China. Methods This study was 89,535 first-recorded colonoscopies Tianjin CRC program, 2012–2020. Of these, 45,380 individuals with complete were included population attributable fraction (PAF)...
Ascites is a typical symptom of liver cirrhosis that caused by variety diseases. severely affects the life quality patients and needs long-term treatment. 25a specific urea transporter inhibitor with diuretic effect does not disturb electrolyte balance. In this study, we aimed to determine therapeutic on ascites dimethylnitrosamine (DMN)-induced cirrhotic rat model. It was found 100 mg/kg significantly increased daily urine output 60% 97% reduced abdominal circumference change 220% 260% in...