A5063759257- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and genetic disorders
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Moyamoya disease diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Neurological and metabolic disorders
- Cardiovascular Function and Risk Factors
- Renal and Vascular Pathologies
- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Cervical and Thoracic Myelopathy
- Migraine and Headache Studies
- Cardiovascular Issues in Pregnancy
- Epilepsy research and treatment
- Receptor Mechanisms and Signaling
- Health and Conflict Studies
Brown University
2022-2025
Michigan United
2025
Providence College
2022-2024
University of Utah
2003-2024
John Brown University
2023-2024
Yahoo (United Kingdom)
2024
National Institute of Neurological Disorders and Stroke
2024
Instituto Nacional de Neurología y Neurocirugía
2024
University of British Columbia
2024
Cornell University
2024
Lacunar infarcts and vascular dementia are important phenotypic characteristics of cerebral autosomal dominant arteriopathy with subcortical leukoencephalopathy, the most common inherited small vessel disease. Individuals disease show variability in nature onset symptoms rates progression, which only partially explained by differences pathogenic mutations NOTCH3 gene. Recognizing early its course securing a molecular diagnosis clinical goals, despite lack proven disease-modifying treatments....
Abstract Background Atrial cardiopathy is a proposed mechanism of embolic stroke undetermined source (ESUS). Left atrial (LA) strain may identify early prior to structural changes. We aim study the associations between LA strain, ESUS, and fibrillation (AF) detection in ESUS. Methods The population included patients with ESUS noncardioembolic (NCE) presenting Rhode Island Hospital Stroke Center January 2016 June 2017 who underwent transthoracic echocardiography. Speckle tracking...
Background: Intracranial Atherosclerosis carries a high recurrence rate. Single center studies have shown that impaired distal perfusion is driver of early recurrence. In this study, we aim to identify predictors 30-day ischemic stroke in multicenter cohort. Methods: This pooled analysis individual patient data from four comprehensive centers hospitalized patients with symptomatic intracranial arterial stenosis (50-99%) the ICA and proximal middle cerebral artery (M1 or M2). The study...
A consistent management algorithm for subjective tinnitus remains to be elucidated. Chronic yields approximately US$2110 in annual health care costs per patient. However, it is unclear whether spending more the of equates with greater patient satisfaction. Thus, aim this study correlate satisfaction demographics, provider recommendations, and total care-related expenditures.A retrospective chart review a questionnaire.All data were collected from large Midwestern hospital.Patients included...
Ample evidence suggests continued racial disparities once listed for liver transplantation, though few studies examine in the selection process listing. The objective of this study, via retrospective chart review, was to determine whether listing transplantation influenced by socioeconomic status and race/ethnicity. We identified 1968 patients with end-stage disease who underwent evaluation at a large, Midwestern center from January 1, 2004 through December 31, 2012 (72.9% white, 19.6%...
Background: Treatment of uncontrolled arterial hypertension reduces the risk cerebral small vessel disease (CSVD) progression, although it is unclear whether this reduction occurs due to blood pressure control or class-specific pleiotropic effects, such as improved beat-to-beat variability with calcium channel blockers. The goal study was investigate influence antihypertensive medication class, particularly blocker, on accumulation white matter hyperintensities (WMH), a radiographic marker...
Objective: Increased visit-to-visit blood pressure variability (vvBPV) has negative effects on multiple organ systems. Prior research suggested that dihydropyridine calcium channel blockers (CCB) may reduce vvBPV, which we attempted to verify in a high-quality dataset with robust statistical methodology. Methods: We performed post hoc analysis of the SPRINT trial and included participants who were CCB either 0 or 100% follow-up study visits. The primary outcome was defined as residual...
Vessel recanalization after cerebral venous thrombosis (CVT) is associated with favorable outcomes and lower mortality. Several studies examined the timing predictors of CVT mixed results. We aimed to investigate CVT. used data from multicenter, international AntiCoagulaTION in Treatment Cerebral Venous Thrombosis (ACTION-CVT) study consecutive patients January 2015 December 2020. Our analysis included that had undergone repeat neuroimaging more than 30 days initiation anticoagulation...
Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich toxic metals. A Pithomyces sp. isolated from the yielded three tyrosine derivatives (1−3), one of which acts as a 5-HT(2a) receptor ligand. This type activity has been associated with migraine preventative and antihypertensive drugs. The isolation characterization compounds 1−3 sesquiterpenes (5−7) that have previously higher plants are reported here.
Abstract Objective Carotid artery web is a possible cause of ischemic stroke, especially in young patients who lack conventional risk factors. The immediate and long‐term outcomes are not well studied. We aimed to determine the association between an ipsilateral carotid in‐hospital stroke recurrence. Methods analyzed data from adult admitted with acute anterior circulation large vessel occlusion at Comprehensive Stroke Center July 2015 March 2023. primary outcome was recurrence secondary...
Background/Objectives: Left ventricular diastolic dysfunction (LVDD) and elevated left filling pressure (LVFP) are strong predictors of clinical outcomes across various populations. However, their diagnostic utility in embolic stroke undetermined source (ESUS) remains unclear. We hypothesized that LVDD with LVFP (based on echocardiography) was more likely to be prevalent ESUS compared non-cardioembolic (NCE) associated atrial fibrillation (AF) follow-up monitoring. Methods: This is a...
To reduce door-to-angiographic reperfusion (DTR) time to 120 minutes for patients presenting with acute ischemic stroke attributed anterior circulation large-vessel occlusion amenable endovascular mechanical thrombectomy.Patients treated thrombectomy before (April 10, 2015, through April 11, 2016) and after 12, 2016, May 2017) implementation of a multitiered notification system were studied. Lean process mapping was used assess inefficiencies multidisciplinary triage. A 3-tiered paging...