Sandra Vazquez
A5040048678- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- History of Education in Spain
- Educator Training and Historical Pedagogy
- Influenza Virus Research Studies
- Computational Drug Discovery Methods
- Public Health and Social Inequalities
- HIV Research and Treatment
- Travel-related health issues
- Herpesvirus Infections and Treatments
- Tissue Engineering and Regenerative Medicine
- Transgenic Plants and Applications
- COVID-19 Impact on Reproduction
- Hepatitis Viruses Studies and Epidemiology
- Maternal and Neonatal Healthcare
- Respiratory viral infections research
- Memory, violence, and history
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Research on Leishmaniasis Studies
National Institute of Allergy and Infectious Diseases
2019-2024
National Institutes of Health
2019-2024
Frederick National Laboratory for Cancer Research
2024
Universidade de Santiago de Compostela
2024
Peking University
2022
New approaches for the prevention and elimination of malaria, a leading cause illness death among infants young children globally, are needed.We conducted phase 1 clinical trial to assess safety pharmacokinetics L9LS, next-generation antimalarial monoclonal antibody, its protective efficacy against controlled human malaria infection in healthy adults who had never or received vaccine malaria. The participants L9LS either intravenously subcutaneously at dose mg, 5 20 mg per kilogram body...
Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed impedes induction neutralizing stem-directed antibodies. A vaccine without variable HA domain has potential to focus immune response on conserved stem. This first-in-human dose-escalation open-label phase 1 clinical trial (NCT03814720) tested an stabilized stem ferritin nanoparticle (H1ssF) based H1 A/New Caledonia/20/1999....
BackgroundSubcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether administered subcutaneously can protect children from P. region where this organism is endemic unclear.MethodsWe conducted 2 trial Mali to assess safety and efficacy subcutaneous 6 10 years age over 6-month malaria season. In part A trial, was assessed at three dose levels adults, followed by assessment two children. B were...
Additional interventions are needed to reduce the morbidity and mortality caused by malaria.
Advances in therapeutic drugs have increased life-expectancies for HIV-infected individuals, but the need an effective vaccine remains. We assessed safety and immunogenicity of HIV-1 vaccine, Trimer 4571 (BG505 DS-SOSIP.664) adjuvanted with aluminum hydroxide (alum), HIV-negative adults.We conducted a phase I, randomized, open-label, dose-escalation trial at National Institutes Health Clinical Center Bethesda, MD, USA. Eligible participants were HIV-negative, healthy adults between 18-50...
Este trabajo lleva a cabo un estudio de caso descriptivo en aula 4º la ESO que se aborda, desde Geografía e Historia, cuestión problemática memoria histórica partir dictadura franquista. La experiencia didáctica orientó transformar los contenidos programados el libro texto y promover diálogo reflexión. El objetivo era observar si alumnado capaz entender, asumir reivindicar, una perspectiva crítica, período histórico presentado, aplicándolo posteriormente otros aprendizajes. metodología...
Este trabajo lleva a cabo un estudio de caso descriptivo en aula 4º la ESO que se aborda, desde Geografía e Historia, cuestión problemática memoria histórica partir dictadura franquista. La experiencia didáctica orientó transformar los contenidos programados el libro texto y promover diálogo reflexión. El objetivo era observar si alumnado capaz entender, asumir reivindicar, una perspectiva crítica, período histórico presentado, aplicándolo posteriormente otros aprendizajes. metodología...
Background: Human monoclonal antibodies (mAb) may offer an important new tool to reduce malaria morbidity and mortality. The antimalarial mAb CIS43LS confers high level protection at doses of 20 or 40 mg/kg intravenously (IV) following controlled human infection (CHMI). ability mediate lower by subcutaneous (SC) route is unknown.Methods: Malaria-naïve participants aged 18-50 years received 1 (n = 7), 5 4), 10 3) IV 4) SC. Pharmacokinetic (PK) assessments safety analysis were performed....