A5003020992- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Viral Infections and Vectors
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Viral Infections and Outbreaks Research
- Virus-based gene therapy research
Walter Reed Army Institute of Research
2023
National Cancer Institute
2022
Center for Cancer Research
2022
Abstract Background: Alveolar soft part sarcoma (ASPS) is a rare, highly vascular tumor with few effective treatment options. Cediranib (C) and sunitinib (S) are potent oral inhibitors of all 3 VEGF receptors. showed substantial single-agent activity (objective response rate [ORR] = 35%) in our previous trial patients (pts) metastatic ASPS (NCT00942877). Here we report phase 2 randomized multicenter single agent C or S pts (NCT01391962). Methods: We conducted an optimal 2-stage design...