A5085630104- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Viral Infections and Vectors
- Pneumonia and Respiratory Infections
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Infectious Diseases and Tuberculosis
- Influenza Virus Research Studies
- HIV Research and Treatment
- Advanced Causal Inference Techniques
- Immunodeficiency and Autoimmune Disorders
- Malaria Research and Control
- Autoimmune and Inflammatory Disorders Research
- Gut microbiota and health
- COVID-19 Impact on Reproduction
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Diet and metabolism studies
- HIV-related health complications and treatments
- Viral Infections and Outbreaks Research
- Statistical Methods and Bayesian Inference
- Complement system in diseases
National Institute of Allergy and Infectious Diseases
2019-2025
National Institutes of Health
2018-2024
National Institutes of Health Clinical Center
2024
Cancer Research And Biostatistics
2022
Clinical Research Management
2022
Division of Cancer Epidemiology and Genetics
2019
National Cancer Institute
2017-2019
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016-2017
Virginia Tech
2016
Abstract Background The natural history of anti-interferon-γ (IFN-γ) autoantibody-associated immunodeficiency syndrome is not well understood. Methods Data 74 patients with anti-IFN-γ autoantibodies at Srinagarind Hospital, Thailand, were collected annually (median follow-up duration, 7.5 years). Annual data for 19 and initial 4 the US National Institutes Health 4.5 Anti-IFN-γ autoantibody levels measured in plasma samples. Results Ninety-one percent Southeast Asian descent; there was a...
Idiopathic CD4 lymphocytopenia (ICL) is a clinical syndrome that defined by lymphopenia of less than 300 cells per cubic millimeter in the absence any primary or acquired cause immunodeficiency. Some 30 years after its original identification, ICL has remained disease obscure cause, with limited evidence respect to prognosis management, despite diagnostic and therapeutic innovations. We evaluated clinical, genetic, immunologic, prognostic characteristics 108 patients who were enrolled during...
Facial palsy is the most common manifestation of Lyme neuroborreliosis (LNB) in United States. This study aimed to describe features patients with early LNB presenting facial and determine if corticosteroids addition antibiotic therapy was associated unfavorable outcome.
Emerging evidence suggests that bacteria residing in colorectal tissue are plausibly associated with cancer (CRC). Prior studies investigated the effects of dietary interventions on fecal microbiome, but few assessed microbiome endpoints. We a high-fiber, high-fruit and -vegetable, low-fat intervention rectal Polyp Prevention Trial (PPT). PPT is 4-year randomized clinical trial goals consuming: 1) ≥ 18 g fiber per 1,000 kcal/day; 2) ≥3.5 servings fruits vegetables 3) <20% kcal/day from fat....
Abstract Background People with HIV and mycobacterial infections can develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy (ART). Severe IRIS has an overlapping clinical phenotype hemophagocytic lymphohistiocytosis (HLH). We evaluated the pathophysiologic similarities between HLH to identify predictors of severity. Methods criteria were applied a longitudinal cohort 80 patients (CD4 &lt;100 cells/µL) infections. Participants subdivided into...
Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people (IDP) has focused cancer and organ transplantation populations. In a prospective cohort of 195 IDP 35 healthy volunteers (HV), antispike immunoglobulin G (IgG) was detected 88% after dose 2, increasing to 93% by 6 months 3. Despite high seroconversion, median IgG levels for never surpassed one-third that HV. binding Omicron BA.1 lowest among variants. Angiotensin-converting enzyme 2 pseudo-neutralization...
People with HIV (PWH) have a higher age-adjusted mortality due to chronic immune activation and age-related comorbidities. PWH also rates of clonal hematopoiesis (CH) than age-matched non-HIV cohorts, however, risk factors influencing the development expansion CH in remain incompletely explored. We investigated relationship between CH, biomarkers, HIV-associated (CD4, CD8 T-cells, nadir CD4 count, opportunistic infections [OIs], reconstitution inflammatory syndrome [IRIS]) diverse cohort...
Abstract Background Although the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are highly efficacious at preventing disease in general population, current data lacking regarding vaccine efficacy (VE) for individuals with mild immunocompromising conditions. Methods A post hoc, cross-protocol analysis of participant-level from blinded phase four randomized, placebo-controlled, 2019 (COVID-19) 3 trials (Moderna, AstraZeneca, Janssen, and Novavax) was performed. We...
Abstract Introduction. Emerging evidence suggests that the bacteria residing in colon and rectal tissue are plausibly associated with colorectal cancer (CRC). Prior studies investigated effects of dietary interventions on fecal microbiome but few assessed endpoints. We a high-fiber, high-fruit -vegetable, low-fat intervention Polyp Prevention Trial (PPT). Methods. PPT is 4-year randomized clinical trial, specific goals including consuming: 1) ≥ 18g fiber per 1,000 kcal/day; 2) 3.5 servings...
Dengue and Zika infections cause illnesses with overlapping clinical manifestations. The aim of this study was to explore the association each these single or grouped laboratory parameters.
To characterize the association of longitudinal changes in maternal anthropometric measures with neonatal anthropometry and to assess what extent late-gestational are associated body composition.In a prospective cohort pregnant women, was measured at six study visits across pregnancy after birth, neonates were fat lean mass calculated. We estimated trajectories separately assessed rate change second (15-28 weeks) third trimester (28-39 relation anthropometry. investigated which tertiles...
In environmental epidemiology, it is of interest to assess the health effects exposures. Some exposure analytes present values that are below laboratory limit detection (LOD). There have been many methods proposed for handling this issue incorporate exposures subject LOD in risk modeling using logistic regression. We a fresh look at handle LOD.We performed comparisons through an extensive simulation study and cancer epidemiology example. The we considered were maximum-likelihood approach,...
Zika has been associated with a variety of severe neurologic manifestations including meningitis and encephalitis. We hypothesized that it may also cause mild to subclinical neurocognitive alterations during acute infection or over the long term. In this observational cohort study, we explored whether alterations, estimate its frequency duration, compare other illnesses in people suspected infection, region Tapachula Chiapas, Mexico 2016–2018. enrolled patients who were at least 12 years old...
In matched case‐crossover studies, it is generally accepted that the covariates on which a case and associated controls are cannot exert confounding effect independent predictors included in conditional logistic regression model. This because any stratum removed by conditioning fixed number of sets stratum. Hence, model not able to detect effects with matching However, some such as time often play an important role modification leading incorrect statistical estimation prediction. Therefore,...
Abstract COVID-19 vaccine research in immune-deficient/disordered people (IDP) has primarily focused on cancer and organ transplantation populations. We followed 195 IDP with varied immune disorders 35 healthy volunteers (HV) from April 2021-April 2022. Anti-spike IgG angiotensin-converting enzyme 2 pseudo-neutralization were measured though six months post-dose 3. was detected 93% of by dynamics HV similar, median levels for < 33% at all timepoints. concentrations lower against Omicron...
Clinical trials initiated during emerging infectious disease outbreaks must quickly enroll participants to identify treatments reduce morbidity and mortality. This may be at odds with enrolling a representative study population, especially when the population affected is undefined. We evaluated utility of Centers for Disease Control Prevention's COVID-19-Associated Hospitalization Surveillance Network (COVID-NET), COVID-19 Case System (CCSS), 2020 United States (US) Census data determine...
Human Bocaviruses (HBoV) can cause acute respiratory tract infections. High coinfection rates cloud its pathogenicity. This study sought to describe the clinical features of HBoV1 disease in children and adults with Influenza-like illness (ILI), exploring associations between viral load, features, seasonality.
Human rhinoviruses (HRVs) are a common cause of influenza-like illness, with the ability to infect upper and lower respiratory tracts. In this study we aim describe clinical molecular features HRV infection in Mexican children adults. We performed hospital-based, 4-year multicenter prospective observational cohort patients illness. Participants who tested positive for were included. described demographic, clinical, laboratory characteristics association between types, illness severity,...