A5020143656- Chronic Obstructive Pulmonary Disease (COPD) Research
- Smoking Behavior and Cessation
- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Energy and Environment Impacts
- Respiratory Support and Mechanisms
- Health and Lifestyle Studies
- Climate Change and Health Impacts
- Respiratory and Cough-Related Research
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protease and Inhibitor Mechanisms
- Air Quality Monitoring and Forecasting
- Genetic Associations and Epidemiology
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Pneumonia and Respiratory Infections
- School Health and Nursing Education
- Long-Term Effects of COVID-19
- Viral gastroenteritis research and epidemiology
Instituto Nacional de Enfermedades Respiratorias
2016-2025
Fundación Con Vida
2022
National Institute of Cardiovascular Diseases
2011
Secretaria de Salud
2002
Dartmouth College
1997
In late March 2009, an outbreak of a respiratory illness later proved to be caused by novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in Mexico. We describe the clinical and epidemiologic characteristics persons hospitalized for pneumonia at national tertiary hospital illnesses Mexico City who had laboratory-confirmed S-OIV infection, also known as swine flu.We used retrospective medical chart reviews collect data on patients. infection confirmed specimens with use...
The efficacy and safety of benralizumab, an interleukin-5 receptor alpha–directed cytolytic monoclonal antibody, for the prevention exacerbations in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) are not known.
Rationale: Women exposed chronically to biomass develop airflow limitation, as tobacco smokers do, but their clinical profile and survival have not been described in detail.Objective: To determine the profile, survival, prognostic factors of chronic obstructive pulmonary disease associated with exposure smoking.Methods: During a 7-yr period (1996–2003), consecutive series 520 patients were recruited followed up at COPD Clinic National Institute Respiratory Diseases. Prognostic evaluated...
We hypothesised that biomass smoke exposure is associated with an airway-predominant chronic obstructive pulmonary disease (COPD) phenotype, while tobacco-related COPD emphysema-predominant phenotype. In this cross-sectional study, female never-smokers and (n=21) ex-cigarette smokers without (n=22) completed computed tomography (CT) at inspiration expiration, function, blood gas, exercise tolerance, quality of life measures. Two radiologists scored the extent emphysema air trapping on CT....
Biomass exposure is an important risk factor for chronic obstructive pulmonary disease (COPD). However, the time-course behavior of FEV1 in subjects exposed to biomass unknown.We undertook this study determine rate decline biomass.Pulmonary function was assessed every year a Mexican cohort patients with COPD associated or tobacco during 15-year follow-up period.The mean significantly lower group (BE-COPD) than smoke (TS-COPD) (23 vs. 42 ml, respectively; P < 0.01). Of TS-COPD group, 11% were...
Effective therapeutics for respiratory viruses are needed. Early data suggest that nitazoxanide (NTZ) may be beneficial treating acute viral illness.
Background: Air pollution is a problem, especially in developing countries. We examined the association between personal exposure to particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) on respiratory health group of adults chronic obstructive pulmonary disease (COPD). Methods: All participants resided Mexico City and during follow-up, PM2.5, symptoms, medications, daily activity were registered daily. Peak expiratory flow (PEF) was measured twice daily, from February...
Background Hypercytokinemia is the main immunopathological mechanism contributing to a more severe clinical course in influenza A (H1N1) virus infections. Most patients infected with pdm09 had increased systemic levels of pro-inflammatory cytokines; including interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). We propose that single-nucleotide polymorphisms (SNPs) promoter regions genes are associated severity infection. Methods 145 (pA/H1N1), 133 influenza-like illness (ILI),...
Background This study assessed the adherence profiles to inhaled therapies and agreement between two patient self-report methods in stable COPD lpatients from seven Latin American countries. Methods observational, cross-sectional, multinational, multicenter involved 795 patients (post-bronchodilator forced expiratory volume 1 second/forced vital capacity [FEV1/FVC] <0.70). Adherence therapy was using specific Test of Inhalers (10-item TAI) generic 8-item Morisky Medication Scale (MMAS-8)...
To investigate the short-term effects of inhaled salmeterol on perception dyspnea and lung function in patients with COPD.Double-blind, crossover, randomized trial comparing placebo over 4 h.Pulmonary laboratory at university medical center.Sixteen symptomatic COPD least 200-mL increase FEV1 after inhalation two puffs (180 microg) albuterol.Visit 1 was used for familiarization. At visits 2 3 (2 to days apart), either (42 or placebo.Lung were measured 0.5, 2, h study medication. Dyspnea by -5...
Aims: Data on differences in clinical characteristics and management of COPD different countries settings are limited. We aimed to characterize the profile patients with a number their treatment order evaluate adherence recommendations international guidelines. Method: This was an observational, international, cross-sectional study physician-diagnosed COPD. Demographic characteristics, risk factors, were collected by physician via internet web-based questionnaire developed for study....
Tobacco smoking is the primary risk factor for chronic obstructive pulmonary disease (COPD). However, recent epidemiological studies have established domestic exposure to wood smoke and other biomass fuels as additional important factors, characteristic in developing countries. Oxidative stress one of mechanisms concerned with pathogenesis COPD. molecular involved onset progress COPD associated specifically that derived from remain unknown. We analyzed relationship between forced expiratory...
Matrix metalloproteinases (MMPs) and C-reactive protein (CRP) are involved in chronic obstructive pulmonary disease (COPD) pathogenesis. The aim of the present work was to determine plasma concentrations MMPs CRP COPD associated biomass combustion exposure (BE) tobacco smoking (TS). Pulmonary function tests, levels MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 were measured BE (n = 40) TS =40) patients, healthy non-smoking (NS) women (controls, n 40). Plasma higher than NS (p <0.01). An inverse...
Introduction: Biomass smoke exposure (BSE) is a recognized cause of COPD particularly in rural areas. However, little research has been focused on BSE suburban Objective: The aim this study was to determine the prevalence COPD, respiratory symptoms (RS) and women living area Mexico City exposed BSE. Methods: A cross-sectional epidemiological survey female population aged >35 years performed using multistage cluster sampling strategy. participants completed questionnaires RS risk factors....
Background . The influenza A H1N1/09 pandemic infected a small number of exposed individuals, which suggests the involvement genetic factors. There are scarce data available on classical HLA class I association with pandemic. Methods We analyzed frequency alleles and haplotypes in case-control study including 138 patients (INF-P) 225 asymptomatic healthy contacts (INF-C) simultaneously recruited. typing was performed by high-resolution sequence-based method. Results Our analysis revealed...
Introduction Health care workers are at high risk of being infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our aim is to evaluate efficacy and safety hydroxychloroquine (HCQ) for prophylaxis disease 19 (COVID-19) in health personnel exposed patients by SARS-CoV-2. Methods Double-blind randomized, placebo-controlled single center clinical trial. Included subjects were caring COVID-19 patients. Main outcome was time symptomatic SARS-CoV-2 infection. Results 127...
Despite the proven benefits of inhaled corticosteroid (ICS)-containing triple therapy for chronic obstructive pulmonary disease (COPD), clinicians limit patient exposure to ICS due risk pneumonia. However, there are multiple factors associated with pneumonia in patients COPD. This post hoc analysis IMPACT trial data aims set risks into a context specific patient-related that contribute The 52-week, double-blind randomized symptomatic COPD and ≥1 exacerbation prior year 2:2:1 once-daily...
Particulate matters (PM) produce adverse effects on the respiratory system and cause COPD. These are thought to involve intrinsic generation of ROS which present in ambient PM (transition metals aromatic organic compounds). Here, we examined chemical composition ultra-microscopic structure PM2.5. The effect this was studied red blood cell (RBC) membranes (ghosts) from healthy volunteers (n = 11) COPD patients 43). were compared with that produced by a Fenton metal-catalytic generator....