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Maria Claudia Burgos Florez

ORCID: 0000-0003-0367-0264
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A5078257989
Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • Influenza Virus Research Studies
  • Respiratory viral infections research
  • Viral gastroenteritis research and epidemiology
  • Herpesvirus Infections and Treatments
  • Viral Infections and Outbreaks Research
  • Viral Infections and Vectors
  • Monoclonal and Polyclonal Antibodies Research
  • Pneumonia and Respiratory Infections
  • HIV Research and Treatment
  • Virus-based gene therapy research
  • vaccines and immunoinformatics approaches
  • Transgenic Plants and Applications

National Institute of Allergy and Infectious Diseases
 2019-2024

National Institutes of Health
 2019-2024

 Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial
OPENALEX - Publications 
Katherine V. Houser Grace Chen Cristina Carter Michelle C. Crank Thuy Nguyen and 69 more Maria Claudia Burgos Florez Nina M. Berkowitz Floreliz Mendoza Cynthia S. Hendel Ingelise J. Gordon Emily E. Coates Sandra Vazquez Judy Stein Christopher L. Case Heather Lawlor Kevin Carlton Martin R. Gaudinski Larisa Strom Amelia R. Hofstetter C. Jason Liang Sandeep Narpala Christian Hatcher Rebecca A. Gillespie Adrian Creanga Masaru Kanekiyo Julie E. Raab Sarah F. Andrews Yi Zhang Eun Sung Yang Lingshu Wang Kwanyee Leung Wing‐Pui Kong Alec W. Freyn Raffael Nachbagauer Peter Palese Robert T. Bailer Adrian B. McDermott Richard A. Koup Jason G. Gall Frank Arnold John R. Mascola Barney S. Graham Julie E. Ledgerwood Joseph P. Casazza LaSonji A. Holman Abidemi O. Ola Pamela Costner Jennifer Cunningham Brenda Larkin Laura Novik Jamie Saunders William Whalen Xiaolin Wang Aba Mensima Eshun Alison Taylor K.-C. Cheng Carolyn M. Laurençot Josephine H. Cox Sandra Sitar Lam Le Iris Pittman Olga Vasilenko Ro Shauna Rothwell Galina V. Yamshchikov Eugenia Burch Somia P. Hickman Olga Trofymenko Catina Boyd Preeti Apte Cora Trelles Cartagena Renunda Hicks Pernell Williams Zana Blaku Colin Tran

10.1038/s41591-021-01660-8 article EN Nature Medicine 2022-02-01
 An influenza hemagglutinin stem nanoparticle vaccine induces cross-group 1 neutralizing antibodies in healthy adults
OPENALEX - Publications 
Alicia T. Widge Amelia R. Hofstetter Katherine V. Houser Seemal F. Awan Grace Chen and 95 more Maria Claudia Burgos Florez Nina M. Berkowitz Floreliz Mendoza Cynthia S. Hendel LaSonji A. Holman Ingelise J. Gordon Preeti Apte C. Jason Liang Martin R. Gaudinski Emily E. Coates Larisa Strom Diane Wycuff Sandra Vazquez Judy Stein Jason G. Gall William C. Adams Kevin Carlton Rebecca A. Gillespie Adrian Creanga Michelle C. Crank Sarah F. Andrews Mike Castro Leonid Serebryannyy Sandeep Narpala Christian Hatcher Bob C. Lin Sarah O’Connell Alec W. Freyn Victoria Rosado Raffael Nachbagauer Peter Palese Masaru Kanekiyo Adrian B. McDermott Richard A. Koup Lesia K. Dropulic Barney S. Graham John R. Mascola Julie E. Ledgerwood Allison Beck Joseph P. Casazza Christopher L. Case John Misasi Abidemi O. Ola Karen Parker Richard Wu Pamela Costner Jamie Saunders Laura Novik William Whalen Xiaolin Wang Aba Mensima Eshun Jennifer Cunningham Anita Arthur Morgan Anderson Justine Jones Brenda Larkin Thuy Nguyen Sandra Sitar Lam Le Iris Pittman Olga Vasilenko Galina V. Yamshchikov Ro Shauna Rothwell Eugenia Burch Olga Trofymenko Sarah H. Plummer Catina Evans Cora Trelles Cartagena Renunda Hicks LaShawn Requilman Pernell Williams Carmencita Graves Shinyi Telscher Gabriela Albright Jessica Bahorich Sashikanth Banappagari Michael Bender Alegria T. Caringal Juliane Guimarães de Carvalho Rajoshi Chaudhuri Mythili Chintamani Jonathan W. Cooper Jacob Demirji Tracey Dinh G Dobrescu Alvenne Goh Deepika Gollapudi Raju Gottumukkala Daniel B. Gowetski Janel Holland-Linn Jin Hong Joe Horwitz Vera B. Ivleva Lisa A. Kueltzo Nadji Lambert

Influenza vaccines could be improved by platforms inducing cross-reactive immunity. Immunodominance of the influenza hemagglutinin (HA) head in currently licensed impedes induction neutralizing stem-directed antibodies. A vaccine without variable HA domain has potential to focus immune response on conserved stem. This first-in-human dose-escalation open-label phase 1 clinical trial (NCT03814720) tested an stabilized stem ferritin nanoparticle (H1ssF) based H1 A/New Caledonia/20/1999....

10.1126/scitranslmed.ade4790 article EN Science Translational Medicine 2023-04-19
 Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study
OPENALEX - Publications 
Martin R. Gaudinski Emily E. Coates Laura Novik Alicia T. Widge Katherine V. Houser and 57 more Eugeania Burch LaSonji A. Holman Ingelise J. Gordon Grace Chen Cristina Carter Martha Nason Sandra Sitar Galina V. Yamshchikov Nina M. Berkowitz Charla Andrews Sandra Vazquez Carolyn M. Laurençot John Misasi Frank Arnold Kevin Carlton Heather Lawlor Jason G. Gall Robert T. Bailer Adrian B. McDermott Edmund V. Capparelli Richard A. Koup John R. Mascola Barney S. Graham Nancy J. Sullivan Julie E. Ledgerwood Cynthia S. Hendel Sarah H. Plummer Pamela Costner Jamie Saunders Floreliz Mendoza Aba Mensima Eshun Joseph P. Casazza Abidemi Ola William Whalen Xiaolin Wang Jennifer Cunningham Olga Vasilenko Catina Boyd Olga Trofymenko Maria Claudia Burgos Florez Somia P. Hickman Ro Shauna Rothwell Iris Pittman Lam Le Brenda Larkin Josephine H. Cox Preeti Apte Renunda Hicks Cora Trelles Cartagena Pernell Williams LaShawn Requilman Thuy Nguyen Colin Tran Sandra Vazquez Michelle Conan-Cibotti Judy Stein Tatiana Beresnev

10.1016/s0140-6736(19)30036-4 article EN The Lancet 2019-01-26
 Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial
OPENALEX - Publications 
Joseph P. Casazza Evan M. Cale Sandeep Narpala Galina V. Yamshchikov Emily E. Coates and 82 more Cynthia S. Hendel Laura Novik LaSonji A. Holman Alicia T. Widge Preeti Apte Ingelise J. Gordon Martin R. Gaudinski Michelle Conan-Cibotti Bob C. Lin Martha Nason Olga Trofymenko Shinyi Telscher Sarah H. Plummer Diane Wycuff William C. Adams Janardan P. Pandey Adrian B. McDermott Mario Roederer Avery N. Sukienik Sijy O’Dell Jason G. Gall Britta Flach Travis L. Terry Misook Choe Wei Shi Xuejun Chen Florence Kaltovich Kevin O. Saunders Judy Stein Nicole A. Doria‐Rose Richard Schwartz Alejandro B. Balazs David Baltimore Gary J. Nabel Richard A. Koup Barney S. Graham Julie E. Ledgerwood John R. Mascola Charla Andrews Anita Arthur Seemal F. Awan Allison Beck Eugeania Burch Maria Claudia Burgos Florez Nina M. Berkowitz Eli Boritz Kevin Carlton Cora Trelles Cartagena Christina Carter Grace Chen Pamela Costner Jennifer Cunningham Daniel C. Douek Aba M. Eshun Catina Evans Renunda Hicks Katherine V. Houser Justine Jones Brenda Larkin Lam Le Floreliz Mendoza Stephen A. Migueles John Misasi Thuy A. Nguyen Abidemi Ola Karen Parker Iris Pittman La’ Shawn Requilman Ro Shauna Rothwell Gretchen L. Schieber Jamie Saunders Sandra Sitar Colin Tran Olga Trofymenko Olga Vasilenko Sana Waheed Lingshu Wang Xiaolin Wang William Whalen Pernell Williams Richard L. C. Wu Kathy Zephir

10.1038/s41591-022-01762-x article EN Nature Medicine 2022-04-11
 Safety, tolerability, and immunogenicity of the respiratory syncytial virus prefusion F subunit vaccine DS-Cav1: a phase 1, randomised, open-label, dose-escalation clinical trial
OPENALEX - Publications 
Tracy J. Ruckwardt Kaitlyn M. Morabito Emily Phung Michelle C. Crank Pamela Costner and 74 more LaSonji A. Holman Lauren A. Chang Somia P. Hickman Nina M. Berkowitz Ingelise J. Gordon Galina V. Yamshchikov Martin R. Gaudinski Bob C. Lin Robert T. Bailer Man Chen Ana M Ortega-Villa Thuy Nguyen Azad Kumar Richard Schwartz Lisa A. Kueltzo Judith A. Stein Kevin Carlton Jason G. Gall Martha Nason John R. Mascola Grace Chen Barney S. Graham Anita Arthur Jennifer Cunningham Aba Mensima Eshun Brenda Larkin Floreliz Mendoza Laura Novik Jamie Saunders Xiaolin Wang William Whalen Cristina Carter Cynthia S. Hendel Sarah H. Plummer Abidemi Ola Alicia T. Widge Maria Claudia Burgos Florez Lam Le Iris Pittman Ro Shauna Rothwell Olga Trofymenko Olga Vasilenko Preeti Apte Renunda Hicks Cora Trelles Cartagena Pernell Williams LaShawn Requilman Colin Tran Shufeng Bai Elizabeth J. Carey Amy L. Chamberlain Ya-Chen Chang Mingzhong Chen Peifeng Chen Jonathan M. Cooper Colleen Fridley Mridul Ghosh Deepika Gollapudi Janel Holland-Linn Joe Horwitz Althaf I. Hussain Vera B. Ivleva Florence Kaltovich Kristin Leach Christopher Lee Amy Liu Xun Liu Slobodanka D. Manceva Amritha Menon Attila Nagy Sarah O’Connell Rahul Ragunathan Jennifer Walters Zhong Zhao

10.1016/s2213-2600(21)00098-9 article EN The Lancet Respiratory Medicine 2021-04-15
 Phase 1 dose-escalation trial evaluating a group 2 influenza hemagglutinin stabilized stem nanoparticle vaccine
OPENALEX - Publications 
Joseph P. Casazza Amelia R. Hofstetter Pamela Costner LaSonji A Holman Cynthia S. Hendel and 44 more Alicia T. Widge Richard L Wu William R Whalen Jennifer Cunningham Anita Arthur Xiaolin Wang Abidemi Ola Jamie Saunders Floreliz Mendoza Laura Novik Maria Claudia Burgos Florez Ana M Ortega-Villa Preeti Apte Larisa Strom Lu Wang Marjaan Imam Manjula Basappa Mursal Naisan Mike Castro Jessica F Trost Sandeep Narpala Hillary A. Vanderven Galina V. Yamshchikov Nina M. Berkowitz Ingelise J. Gordon Sarah H. Plummer Diane Wycuff Sandra Vazquez Rebecca A. Gillespie Adrian Creanga William C. Adams Kevin Carlton Jason G. Gall Adrian B. McDermott Leonid Serebryannyy Katherine V. Houser Richard A. Koup Barney S. Graham Julie E Ledgerwood John R. Mascola Theodore C. Pierson Sarah F. Andrews Masaru Kanekiyo Lesia K. Dropulic

10.1038/s41541-024-00959-0 article EN cc-by npj Vaccines 2024-09-17
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