A5060655661- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- Microfluidic and Capillary Electrophoresis Applications
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Surface Modification and Superhydrophobicity
- Racial and Ethnic Identity Research
- Micro and Nano Robotics
- Food Security and Health in Diverse Populations
- Vaccine Coverage and Hesitancy
- Electrical and Bioimpedance Tomography
- Tuberculosis Research and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Immunotherapy and Biomarkers
- 3D Printing in Biomedical Research
- Blood properties and coagulation
- Biochemical and Molecular Research
- Extracellular vesicles in disease
- Characterization and Applications of Magnetic Nanoparticles
- Advanced biosensing and bioanalysis techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mycobacterium research and diagnosis
- COVID-19 Impact on Reproduction
- Bacterial Identification and Susceptibility Testing
- Mobile Health and mHealth Applications
University of California, Los Angeles
2012-2024
California NanoSystems Institute
2014-2015
UCLA Jonsson Comprehensive Cancer Center
2015
Los Angeles City College
2015
Office of Infectious Diseases
2015
Single-cell morphological analysis – gradient antibiotic susceptibility rapid bacterial detection in blood.
Abstract Background Although the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are highly efficacious at preventing disease in general population, current data lacking regarding vaccine efficacy (VE) for individuals with mild immunocompromising conditions. Methods A post hoc, cross-protocol analysis of participant-level from blinded phase four randomized, placebo-controlled, 2019 (COVID-19) 3 trials (Moderna, AstraZeneca, Janssen, and Novavax) was performed. We...
The recent SARS-CoV-2 pandemic underscores the need for rapid and accurate prediction of clinical thrombotic events. Here, we developed nanoengineered multichannel immunosensors detection circulating biomarkers associated with thrombosis, including C-reactive protein (CRP), calprotectin, soluble platelet selectin (sP-selectin), D-dimer. We fabricated using fiber laser engraving carbon nanotubes CO 2 cutting microfluidic channels, along electrochemical deposition gold nanoparticles to...
In this issue we highlight three recent papers that demonstrate new strategies to extend the capabilities of paper microfluidics. Paper (a mesh porous fibers) has a long history as substrate perform biomolecular assays. Traditional lateral flow immunoassays (LFAs) are widely used for rapid diagnostic tests, and well when yes or no answer is required analyte interest at relatively high concentrations. High concentrations because usually only small volume analyte-containing fluid flows past...
Interleukin-6 blockade (IL-6) has become a focus of therapeutic investigation for the coronavirus disease 2019 (COVID-19).We report case 34-year-old with COVID-19 pneumonia receiving an IL-6 receptor antagonist (IL-6Ra) who developed spontaneous colonic perforation. This perforation occurred despite benign abdominal exam and in absence other known risk factors associated perforation.Examination colon by electron microscopy revealed numerous intact severe acute respiratory syndrome 2...
To analyze community experiences involving COVID-19 vaccination access and equity in Black Latina/o/x communities within South Los Angeles, using a socioecological framework.
Microfluidic systems are often dominated by their surfaces because of the high surface area to volume ratios in microchannel flows or drop-based systems. Here we highlight recent work on engineering and exploiting effects control formation motion microdrops. We using precisely microstructured wetting repel all manner liquids even when liquid-air tension is low. In a second paper, selective capillary filling draining used pattern liquid cell-laden gels for 3D culture. A final paper making use...
Magnetic ratcheting cytometry is a promising approach to separate magnetically-labeled cells and magnetic particles based on the quantity of material. We have previously reported ability this technique cells. Here, with new chip design, containing high aspect ratio permalloy micropillar arrays, we demonstrate rapidly concentrate collect superparamagnetic iron oxide particles. The platform consists mechatronic wheel used generate control cycling external field that impinges “ratcheting chip.”...
A 44-year-old woman undergoing therapy for acute promyelocytic leukemia (APL) developed disseminated tuberculosis. Mycobacterium tuberculosis (TB) was isolated from the blood and sputum. Initial drug susceptibility testing (DST) of isolate revealed resistance to isoniazid ethambutol but sputum showed no resistance. Due concerns, patient treated with multiple second third-line drugs, suffered side effects. To further investigate DST discrepancies, whole genome sequencing (WGS) performed on...