A5043364648- Medical Imaging and Analysis
- Microfluidic and Bio-sensing Technologies
- Dental Radiography and Imaging
- 3D Printing in Biomedical Research
- Spinal Fractures and Fixation Techniques
- Cellular Mechanics and Interactions
- Biosensors and Analytical Detection
- Maternal and Perinatal Health Interventions
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Neural Networks and Applications
- Image Processing and 3D Reconstruction
- Innovative Microfluidic and Catalytic Techniques Innovation
- Algal biology and biofuel production
- Micro and Nano Robotics
- Assisted Reproductive Technology and Twin Pregnancy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Management of metastatic bone disease
- Cell Adhesion Molecules Research
- Medical Imaging Techniques and Applications
- Spaceflight effects on biology
- Alkaline Phosphatase Research Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Respiratory viral infections research
- Advanced Fiber Laser Technologies
VIR Biotechnology (United States)
2025
Vir Biotechnology (Switzerland)
2025
University of California, Los Angeles
2014-2023
German BioImaging – Gesellschaft für Mikroskopie und Bildanalyse
2020
University of California System
2016
Los Angeles City College
2016
National Institutes of Health Clinical Center
2013-2015
National Institutes of Health
2012-2014
California NanoSystems Institute
2014
Abstract Euglena gracilis ( E. ) has been proposed as one of the most attractive microalgae species for biodiesel and biomass production, which exhibits a number shapes, such spherical, spindle-shaped, elongated. Shape is an important biomarker , serving indicator biological clock status, photosynthetic respiratory capacity, cell-cycle phase, environmental condition. The ability to prepare uniform shape at high purities significant implications various applications in research industrial...
To design and validate a fully automated computer system for the detection anatomic localization of traumatic thoracic lumbar vertebral body fractures at computed tomography (CT).This retrospective study was HIPAA compliant. Institutional review board approval obtained, informed consent waived. CT examinations in 104 patients (mean age, 34.4 years; range, 14-88 32 women, 72 men), consisting 94 with positive findings (59 fractures) 10 control (without fractures), were performed. There 141...
Purpose To design and validate a computer system for automated detection quantitative characterization of sclerotic metastases the thoracolumbar spine on computed tomography (CT) images. Materials Methods This retrospective study was approved by institutional review board HIPAA compliant; informed consent waived. The data set consisted CT examinations in 49 patients (14 female, 35 male patients; mean age, 57.0 years; range, 12–77 years), demonstrating total 532 lesions greater than 0.3 cm3...
The asthma-obesity syndrome represents a major public health concern that disproportionately contributes to asthma severity and induces insensitivity therapy. To date, no study has shown an intrinsic difference between human airway smooth muscle (HASM) cells derived from nonobese subjects those obese subjects. objective of this was address whether there is greater response agonist-induced calcium mobilization, phosphorylation myosin light chain (MLC), shortening in HASM were age sex matched....
<title>Abstract</title> <bold>For nearly 30 years, Goose/Guangdong (Gs/Gd)-derived highly pathogenic avian influenza (HPAI) H5N1 viruses have posed significant risks to economic stability, food security, and public health. Virus evolution has resulted in various clades, including the panzootic subclade 2.3.4.4b, recognized for its pandemic potential. Here we present potent vitro activity of FNI9, a pan-influenza NA-inhibiting monoclonal antibody, against range pseudoparticles with NA...
We study the behaviors of ellipsoidal microalgal cells with varying aspect ratios using inertial microfluidics for biofuels and environmental applications.
Nucleic acid amplification assays including loop-mediated isothermal (LAMP) are routinely used in diagnosing diseases and monitoring water food quality. The results of these commonly measured with an analog fluorescence readout, which requires specialized optical equipment can lack quantitative precision. Digital analysis small fluid compartments based on exceeding a threshold level enhance the precision nucleic (i.e., digital assays), but still systems for readout inclusion fluorescent dye....
The emergence of epigenetic gene regulation and its role in disease have motivated a growing field diagnostics for risk assessment screening. In particular, irregular cytosine DNA base methylation has been implicated several diseases, yet the methods detecting these marks are limited to lengthy protocols requiring bulky costly equipment. We demonstrate simple workflow methylated CpG dinucleotides synthetic genomic samples using methylation-sensitive restriction enzyme digestion followed by...
Imaging flow cytometry is a powerful tool by virtue of its capability for high-throughput cell analysis. The advent high-speed optical imaging methods on microfluidic platform has significantly improved throughput and brought many degrees freedom to instrumentation applications over the last decade, but it also poses predicament chips. Specifically, as increases, speed increases (currently reaching 10 m/s): consequently, increased hydrodynamic pressure chip deforms wall microchannel produces...
Microalgal biofuels and biomass have ecofriendly advantages as feedstocks. Improved understanding utilization of microalgae require large-scale analysis the morphological metabolic heterogeneity within populations. Here, with Euglena gracilis a model microalgal species, we evaluate how fluorescence- brightfield-derived-image-based descriptors vary during environmental stress at single-cell level. This is achieved new multiparameter fluorescence-imaging cytometric technique that allows...
We present a detailed study on the generation of widely tunable visible light through four wave mixing in specifically designed micro-structured fibers. The fiber's properties are optimized for an efficient conversion to and near infrared with combined tunability from 620 910 nm picosecond Yb-doped source biomedical applications.
Twin vaginal deliveries (VDs) are often performed in the operating room (OR) given risk of conversion to cesarean delivery (CD) for aftercoming twin. We aim investigate rates CD planned twin VDs and identify predictors outcomes conversion.A retrospective cohort study all women who underwent a VD at two large academic medical centers over 4 years. Demographic outcome data were chart abstracted. Various statistical tests used evaluate influence perinatal variables on mode possible...
Degenerative disc disease (DDD) can be identified as hyperdense regions of bone and osseous spur formation in the spine that become more prevalent with age. These act confounding factors search for alternative foci such neoplastic processes. We created a preliminary CAD system detects DDD on CT images. After is segmented, cortical shell each vertebral body unwrapped onto 2D map. Candidates are detected from map based their intensity gradient. The detections remapped into 3D space level set...
Degenerative disc disease (DDD) develops in the spine as vertebral discs degenerate and osseous excrescences or outgrowths naturally form to restabilize unstable segments of spine. These excrescences, osteophytes, may progress stabilize size reaches a new equilibrium point. We have previously created CAD system that detects DDD. This paper presents determine severity DDD individual levels. will be useful monitor developing DDD, rapid growth indicate there is greater stabilization problem...
Abstract Mechanical measurements of cells can provide unique insights into cell state and disease processes. The overall mechanical properties be heavily affected by the stiffest organelle, nucleus. However, it is challenging to fully characterize internal nuclear structures in most measurement platforms. Here, we demonstrate single-cell deformability whole stained nuclei a fluorescence imaging flow cytometry platform. We also introduce bending energy derived metrics as way normalize...
Magnetic ratcheting cytometry is a promising approach to separate magnetically-labeled cells and magnetic particles based on the quantity of material. We have previously reported ability this technique cells. Here, with new chip design, containing high aspect ratio permalloy micropillar arrays, we demonstrate rapidly concentrate collect superparamagnetic iron oxide particles. The platform consists mechatronic wheel used generate control cycling external field that impinges “ratcheting chip.”...