A5085381042- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrowetting and Microfluidic Technologies
- Advanced Sensor and Energy Harvesting Materials
- Cell Image Analysis Techniques
- Orbital Angular Momentum in Optics
- Electrohydrodynamics and Fluid Dynamics
- Laser Material Processing Techniques
- Micro and Nano Robotics
- Single-cell and spatial transcriptomics
- Digital Holography and Microscopy
- Cellular Mechanics and Interactions
- Biosensors and Analytical Detection
- Modular Robots and Swarm Intelligence
- Neuroscience and Neural Engineering
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanopore and Nanochannel Transport Studies
- Optical Coherence Tomography Applications
- Conducting polymers and applications
- Advanced MEMS and NEMS Technologies
- Force Microscopy Techniques and Applications
- Dielectric materials and actuators
- Innovative Energy Harvesting Technologies
Nara Institute of Science and Technology
2018-2025
RIKEN Center for Biosystems Dynamics Research
2018-2023
RIKEN
2016-2022
German BioImaging – Gesellschaft für Mikroskopie und Bildanalyse
2020
Materials Science & Engineering
2019
Northwest African American Museum
2018-2019
National Archives and Records Administration
2019
Osaka University
2013-2018
Quantitative Biology Center
2016-2018
Nitto RIKEN (Japan)
2017
Combining the strength of flow cytometry with fluorescence imaging and digital image analysis, is a powerful tool in diverse fields including cancer biology, immunology, drug discovery, microbiology, metabolic engineering. It enables measurements statistical analyses chemical, structural, morphological phenotypes numerous living cells to provide systematic insights into biological processes. However, its utility constrained by requirement fluorescent labeling for phenotyping. Here we present...
Ocean wave energy is a promising clean and renewable source to mitigate the global crisis environmental issues. Here, guided-liquid-based isotropic triboelectric–electromagnetic-hybrid nanogenerator (iTEHG) developed for efficient sustainable harvesting of omnidirectional ocean energy. The fully-enclosed iTEHG based on triboelectric (TENG) electromagnetic generator (EMG), with structure design unique concentric circular electrode pair built tilted satellite-dish-inspired plate gravity-guided...
Abstract The monitoring of currents in the abyssal ocean is an essential foundation deep-sea research. state-of-the-art current meter has limitations such as requirement a power supply for signal transduction, low pressure resistance, and narrow measurement range. Here, we report fully integrated, self-powered, highly sensitive system which ultra-sensitive triboelectric nanogenerator harvests energy self-powered sensing tiny motions down to 0.02 m/s. Through unconventional magnetic coupling...
Abstract Imaging flow cytometry (IFC) combines the imaging capabilities of microscopy with high throughput cytometry, offering a promising solution for high-precision and high-throughput cell analysis in fields such as biomedicine, green energy, environmental monitoring. However, due to limitations framerate real-time data processing, existing IFC systems has been restricted approximately 1000-10,000 events per second (eps), which is insufficient large-scale analysis. In this work, we...
Human iPS cell (iPSC)-derived cardiomyocytes (CMs) hold promise for drug discovery heart diseases and cardiac toxicity tests. To utilize human iPSC-derived CMs, the establishment of three-dimensional (3D) tissues from CMs other cells, a sensitive bioassay system to depict physiological function are anticipated. We have developed heart-on-a-chip microdevice (HMD) as novel consisting dynamic culture-based 3D microtissues derived iPSCs microelectromechanical (MEMS)-based microfluidic chips. The...
Microfluidics has become recognized as a powerful platform technology with wide range of applications in various fields, such biology, biomedicine, chemistry and environment. To achieve higher performance, microfluidic devices are required to have superior optical transparency; mechanical, chemical thermal stability; well easy design fabrication. All these requirements make glass an attractive ideal material for the fabrication due its excellent characteristics optical, thermal, electrical...
Building change detection (BCD) is essential for urban dynamic measurement. Deep learning has demonstrated significant potential in image processing, providing powerful feature extraction capabilities BCD tasks. However, existing methods do not adequately mine multiscale information and ignore the importance of alignment, leading to an inadequate representation internal structure. Therefore, we propose a hybrid attention-aware Transformer network (HATNet) designed effectively extract...
Abstract The development of reliable, sustainable, and economical sources alternative fuels to petroleum is required tackle the global energy crisis. One such microalgal biofuel, which expected play a key role in reducing detrimental effects warming as microalgae absorb atmospheric CO 2 via photosynthesis. Unfortunately, conventional analytical methods only provide population‐averaged lipid amounts fail characterize diverse population cells with single‐cell resolution non‐invasive...
Efficient and reliable manipulation of biological particles is crucial in medical diagnosis chemical synthesis. Inertial microfluidic devices utilizing passive hydrodynamic forces the secondary flow have drawn considerable attention for their high throughputs, low costs, harmless particle manipulation. However, as dominant mechanism, inertial lift force difficult to quantitatively analyze because uncertainties its magnitude direction. The equilibrium position varies along migration process,...
The drug susceptibility of leukemia cells in whole blood is evaluated by using extreme-throughput imaging flow cytometry with deep learning.
Here, we achieve the separation and enrichment of Escherichia coli clusters from its singlets in a viscoelastic microfluidic device. E. coli, an important prokaryotic model organism widely used microbial factory, can aggregate clusters, leading to biofilm development that be detrimental human health industrial processes. The ability obtain high-purity populations is significance for biological, biomedical, applications. In this study, polystyrene particles two different sizes, 1 4.8 μm, are...
The use of ocean sensors is crucial for exploration the and harnessing potential its resources. However, conventional are limited by their fabrication techniques, which result in that large size, have high-power consumption requirements, involve complex deployment processes. fulfilling observation requirements harsh marine environment presents a formidable challenge these devices. Microelectromechanical system (MEMS) technologies offer promising solution will enable development new...
We investigated and established a method, using femtosecond laser processing, to fabricate 100%-glass-based 12-μm ultra-thin flexible micro-fluidic chip.
Cell rotation is one of the most important techniques for cell manipulation in modern bioscience, as it not only permits observation from any arbitrary angle, but also simplifies procedures analyzing mechanical properties cells, characterizing physiology, and performing microsurgery. Numerous approaches have been reported rotating cells a wide range academic industrial applications. Among them, popular are micro-robot-based direct contact field-based non-contact methods (e.g., optical,...
Over the past two decades, inertial microfluidics, which works at an intermediate range of Reynolds number (∼1 < Re ∼100), has been widely used for particle separation due to its high-throughput and label-free features. This work proposes a novel method continuous particles by size using with assistance symmetrical sheath flows in straight microchannel. Here, larger (>3 μm) are arranged close channel sidewalls, while smaller (<2 remain flowing along centerline. conclusion is supported...