A5091908137- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Estrogen and related hormone effects
- AI in cancer detection
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Advanced Proteomics Techniques and Applications
- Medical Image Segmentation Techniques
- Cancer and Skin Lesions
- Gene expression and cancer classification
- Advanced Biosensing Techniques and Applications
- Cell Image Analysis Techniques
- Genomics and Chromatin Dynamics
- Digital Imaging for Blood Diseases
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Mass Spectrometry Techniques and Applications
- Image Retrieval and Classification Techniques
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
Wuhan University
2022-2025
Peking University
2020-2024
Peking University Cancer Hospital
2021-2024
Wuhan University of Technology
2024
Peking University People's Hospital
2024
Second Xiangya Hospital of Central South University
2018-2021
Central South University
2013-2021
ORCID
2021
King University
2020
Hong Kong University of Science and Technology
2016-2019
Abstract Imaging flow cytometry (IFC) combines the imaging capabilities of microscopy with high throughput cytometry, offering a promising solution for high-precision and high-throughput cell analysis in fields such as biomedicine, green energy, environmental monitoring. However, due to limitations framerate real-time data processing, existing IFC systems has been restricted approximately 1000-10,000 events per second (eps), which is insufficient large-scale analysis. In this work, we...
Histone variants, present in various cell types and tissues, are known to exhibit different functions. For example, histone H3.3 H2A.Z both involved gene expression regulation, whereas H2A.X is a specific variant that responds DNA double-strand breaks. In this study, we characterized H4G, novel hominidae-specific H4 variant. We found H4G expressed variety of human lines tumor-stage dependent overexpression tissues from breast cancer patients. localized primarily the nucleoli nucleus. This...
Breast cancer is one of the most common types and leading cause cancer-related death. Diagnosis breast based on evaluation pathology slides. In era digital pathology, these slides can be converted into whole slide images (WSIs) for further analysis. However, due to their sheer size, WSIs diagnoses are time consuming challenging. this study, we present a lightweight architecture that consists bilinear structure MobileNet-V3 network, (BM-Net), analyze WSIs. We utilized WSI dataset from...
Introduction To evaluates the expression of SIRT7 in UTUC as well predictive value for prognosis patients undergoing radical nephroureterectomy followed platinum-based adjuvant chemotherapy. Methods Pathological samples 146 with clinical stage T2 and above nephrectomy (RNU) were collected. All received cisplatin-based chemotherapy 40 second-line immunotherapy after disease progression. The relationship between level by immunohistochemistry (IHC) clinicopathological characteristics,...
The Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway, which is dysregulated in various cancers, controls the assembly eukaryotic translation initiation factor 4F (eIF4E) complex. However, whether aberrant expression phosphorylated (p-Akt), mTOR (p-mTOR) and eIF4E (p-eIF4E) associated with clinicopathological characteristics surgically resected non-small cell lung cancer (NSCLC) has been rarely reported. Here, we investigated p-Akt, p-mTOR p-eIF4E proteins NSCLC by...
Twenty-two dogs were managed surgically for a single extrahepatic portosystemic shunt; 12 with surgical ligation and 10 an Ameroid constrictor. Utilization of the constrictor significantly decreased surgery time to approximately half that technique. A intraoperative postoperative complication rate was noted group. Follow-up evaluation demonstrated comparable efficacy when comparing techniques. The offered occlusion technique management extra-hepatic shunt equally effective while shortening...
Matching whole slide histopathology images to provide comprehensive information on homologous tissues is beneficial for cancer diagnosis. However, the challenge arises with Giga-pixel (WSIs) when aiming high-accuracy matching. Learning-based methods are difficult generalize well large-size WSIs, necessitating integration of traditional matching enhance accuracy as size increases. In this paper, we propose a multi-size guiding method applicable requirements. Specifically, design learning...
Background: Structural variations (SVs) are common genetic alterations in the human genome that could cause different phenotypes and diseases, including cancer. However, detection of structural using second-generation sequencing was limited by its short read length, which restrained our understanding variations. Methods: In this study, we developed a 28-gene panel for long-read employed it to Oxford Nanopore Technologies Pacific Biosciences platforms. We analyzed 28 breast cancer-related...
Abstract High-plex proteomic technologies have made substantial contributions to mechanism studies and biomarker discovery in complex diseases, particularly cancer. Despite technological advancements, inherent limitations individual approaches persist, impeding the achievement of comprehensive quantitative insights into proteome. In this study, we employed two widely used technologies, Mass Spectrometry (MS) Reverse Phase Protein Array (RPPA) analyze identical samples, aiming systematically...
Apocrine carcinoma is a rare subtype of invasive ductal breast cancer that shows apocrine differentiation and largely triple-negative immunohistology. Triple-negative cancers are known to have more aggressive clinical courses. However, unlike most other subtypes, it reported (TNAC) has better prognosis. Due the scarcity studies, our knowledge regarding its behavior, prognosis response therapy very limited. In this study, we retrospectively retrieved 41 cases from database, with an average...
Accurate detection of HER2 expression through immunohistochemistry (IHC) is great clinical significance in the treatment breast cancer. However, manual interpretation challenging, due to interobserver variability among pathologists. We sought explore a deep learning method predict level and gene status based on Whole Slide Image (WSI) IHC section. When applied 228 invasive carcinoma no special type (IBC-NST) DAB-stained slides, our GrayMap+ convolutional neural network (CNN) model accurately...
In estrogen receptor (ER)-positive breast cancer, changes in biomarker expression after neoadjuvant therapy indicate the therapeutic response and are prognostic. However, there is limited information about alteration caused by endocrine ER-positive human epidermal growth factor 2 (HER2)-negative cancer. We recruited ER-positive/HER2-negative cancer patients who received chemotherapy (NCT), (NET), or sequential endocrine-chemotherapy (NECT) at Peking University Cancer Hospital from 2015 to...
Abstract Cisplatin (CDDP) resistance has been established to significantly impact Bladder Cancer (BCa) therapy. On the other hand, crucial regulatory involvement of SIRT7 and EZH2 in bladder cancer development is well known. Herein, collaborative roles underlying mechanisms CDDP were explored. Immunohistochemistry (IHC) Western Blot (WB) analyses used assess expression levels SIRT7/EZH2 RND3 tissues, normal ureteral epithelial cells, cell lines. Furthermore, various treatments on UMUC3...
Abstract Purpose PR loss in ER+/HER2- breast cancer indicates worse prognosis and insensitivity to anti-estrogen therapy, while the mechanisms of remain unrevealed. Methods In this study, ER+/PR+/HER2- ER+/PR-/HER2- cases from TCGA were used. 1387 pathways analyzed used as variables for classifying two groups with LASSO regression. Results can be classified by a combination 13 using their activity score. Among pathways, those involving growth factors ion-channel transporters most significant...
Regulators of histone acetylation are promising epigenetic targets for therapy in breast cancer. In this study, we comprehensively analyzed the expression modulator genes cancer using TCGA data sources. A gene signature composed eight modulators (HAMs) was found to be effective classification and prognosis cancers, especially HER2-enriched basal-like molecular subtypes. The consist two writers (GTF3C4 CLOCK), erasers (HDAC2 SIRT7) four readers (BRD4, BRD7, SP100, BRWD3). Both writer eraser...
Triple-negative breast cancer is a heterogeneous disease with different molecular and histological subtypes. The Androgen receptor expressed in portion of triple-negative cases the activation androgen pathway thought to be subtyping signature as well therapeutic target for cancer. Thus, identification status important both characterization andclinical management. In this study, we investigate expression metaplastic luminal subtypes found that was downregulated compared subtype. Using random...
<sec><b>Objective</b>To explore the application of genetic abnormalities in diagnosis angioimmunoblastic T-cell lymphoma (AITL) and reliable pathological prognostic factors.</sec><sec><b>Methods</b>This study included 53 AITL cases, which were reviewed for morphological patterns, immunophenotypes, presence Hodgkin Reed-Sternberg (HRS)-like cells, co-occurrence B cell proliferation. The Epstein-Barr virus (EBV)-positive cells tissues counted, cases classified into “EBV encoded RNA (EBER)...
Numerous mathematical models and retrospective analyses have been conducted to explore the natural progression of breast cancer, but there is no precise timeline as how long it takes cancer progress from stages 0 IV. Studying history requires follow-up a large cohort patients who received treatment following diagnosis for period, this has become unpractical in modern era. In study, we quantified using Surveillance, Epidemiology, End Results (SEER) database which was collected...
Abstract Background Breast leiomyoma is a rare benign mesenchymal tumor, accounting for less than 1% of all breast neoplasms. Cases atypical even more rarely reported and its diagnostic criteria together with clinical courses not cleared defined. Case presentation We described two patients leiomyomas. One has unilateral leiomyoma, the other one bilateral For case, left-side tumor was diagnosed as while right-side leiomyoma. The morphological features that lead to diagnosis are invasive...