Hemalatha Srinivasalu
A5061603335- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Patient-Provider Communication in Healthcare
- Delphi Technique in Research
- Ocular Diseases and Behçet’s Syndrome
- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Acute Lymphoblastic Leukemia research
- Pericarditis and Cardiac Tamponade
- Mechanical Circulatory Support Devices
- Parvovirus B19 Infection Studies
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Coronary Artery Anomalies
- Diabetes and associated disorders
- Retinal and Optic Conditions
- Spinal Hematomas and Complications
- Neurogenetic and Muscular Disorders Research
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders
- Congenital Heart Disease Studies
- Clinical Reasoning and Diagnostic Skills
National Institutes of Health
2022-2025
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2021-2025
George Washington University
2013-2025
Children's National
2013-2024
National Hospital
2022-2024
Duke University
2024
Izaak Walton Killam Health Centre
2022
University of Alabama at Birmingham
2022
Dalhousie University
2022
Hospital for Special Surgery
2021
Significance In this report we identify genetic susceptibility variants for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome, the most common fever syndrome in children. PFAPA shares risk loci at IL12A , STAT4, IL10 CCR1-CCR3 with Behçet’s disease recurrent defining a family of spectrum disorders. Differential HLA associations along may determine where individual phenotypes fall among
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever in children. There considerable heterogeneity management strategies a lack of evidence-based treatment guidelines. Consensus plans (CTPs) are standardized regimens that derived based upon best available evidence current practices way to enable comparative effectiveness studies identify optimal therapy less costly execute than randomized, double blind placebo controlled...
Abstract Objective Sjögren syndrome in children is a poorly understood autoimmune disease. We aimed to describe the clinical and diagnostic features of diagnosed with explore how 2016 ACR/EULAR classification criteria apply this population. Methods An international workgroup retrospectively collected cases under 18 years age from 23 centres across eight nations. analysed patterns symptoms, workup, applied criteria. Results identified 300 syndrome. The majority patients n = 232 (77%) did not...
Objective To evaluate the influence of pelvic magnetic resonance imaging (MRI) findings on axial disease assessment in juvenile spondyloarthritis (JSpA). Methods This was a cross-sectional study patients with JSpA suspected disease. Three experts reviewed each case and rated their confidence (–3 to +3) presence disease, first clinical data second MRI data. Agreement defined as ≥ 2/3 rating ≤ –1 or 1, high agreement –2 2. The association features both global assessments tested modified...
The goal was to develop and validate classification criteria for axial juvenile spondyloarthritis (SpA; AxJSpA).
Objective Magnetic resonance imaging (MRI) is pivotal in the assessment of early sacroiliitis children. We aimed to evaluate agreement between local radiology reports and central reviewers for active inflammation structural damage at sacroiliac (SI) joints. Methods Eight hospitals each contributed up 20 cases consecutively imaged children adolescents with juvenile idiopathic arthritis suspected sacroiliitis. Studies were independently reviewed by 3 experienced musculoskeletal pediatric...
Abstract Background: A novel paediatric disease, multi-system inflammatory syndrome in children, has emerged during the 2019 coronavirus disease pandemic. Objectives: To describe short-term evolution of cardiac complications and associated risk factors patients with children. Methods: Retrospective single-centre study confirmed children treated from 29 March, 2020 to 1 September, 2020. Cardiac acute phase were defined as decreased systolic function, coronary artery abnormalities, pericardial...
Objective To validate the Juvenile Spondyloarthritis Disease Activity Index (JSpADA), and modified versions thereof, in a North American cohort of patients with enthesitis-related arthritis (ERA). Methods We utilized Childhood Arthritis Rheumatology Research Alliance Registry database ERA to JSpADA its modifications (JSpADA6-no Schober, no C-reactive protein [CRP]/erythrocyte sedimentation rate [ESR]; JSpADA7-no Schober; CRP/ESR) using Outcome Measures principles face validity,...
To describe an atypical presentation of Tubulointerstitial Nephritis and Uveitis (TINU), with challenges in treatment course. A 12-year-old Hispanic female presented to the National Eye Institute's clinic bilateral blurred vision, red eyes photophobia, not responsive topical steroids. On exam, she had severe panuveitis areas subretinal fluid. During her evaluation, was noted have elevated serum creatinine. kidney biopsy confirmed presence tubulointerstitial nephritis interstitial fibrosis....
Abstract Background and objective Evidence for the treatment of multisystem inflammatory syndrome in children (MIS-C) is lacking. Anakinra, which targets IL-1-mediated inflammation, reserved refractory cases MIS-C; however, its use MIS-C not clearly established. Patients methods To examine a role anakinra MIS-C, we performed single center observational cohort study all patients diagnosed at our children’s hospital from May 15 to November 15, 2020. Demographics, clinical features, diagnostic...
Erythema of the ear lobe in context Lyme disease is caused by either borrelial lymphocytoma or localized erythema migrans. Here we present a case chondritis limited to cartilage disease. The patient was treated with ceftriaxone complete resolution symptoms.
Purpose of review This summarizes latest developments in treatment juvenile spondyloarthritis (JSpA), specifically enthesitis-related arthritis (ERA) and psoriatic (JPsA). Recent findings There has been addition biologic disease modifying antirheumatic drugs (bDMARDs) beyond tumor necrosis factor inhibitors (TNFi) for JSpA such as IL-17 blockers, IL-23 janus activating kinase with favorable safety profile. Conducting robust clinical trials this subpopulation JIA remains a challenge;...