A5027817508- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Orthopedic Infections and Treatments
- Pneumonia and Respiratory Infections
- Viral Infections and Immunology Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Inflammasome and immune disorders
- Innovations in Medical Education
- Rabies epidemiology and control
- Bacterial biofilms and quorum sensing
- Child and Adolescent Health
- Dermatological and COVID-19 studies
- Infective Endocarditis Diagnosis and Management
- Viral gastroenteritis research and epidemiology
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- Fungal Infections and Studies
- Food Allergy and Anaphylaxis Research
- Kawasaki Disease and Coronary Complications
- Antibiotic Use and Resistance
- Neonatal and Maternal Infections
- Dermatology and Skin Diseases
- Clinical Reasoning and Diagnostic Skills
- COVID-19 Clinical Research Studies
Children's National
2018-2025
George Washington University
2018-2025
Foundation for the National Institutes of Health
2021
Children's Hospital of Pittsburgh
2021
University of Arkansas for Medical Sciences
2007-2016
Arkansas Children's Hospital
2008-2014
University of Washington
2007
University School
1996
Case Western Reserve University
1996
Despite worldwide spread of severe acute respiratory syndrome coronavirus-2, few publications have reported the potential for disease in pediatric population. We report 177 infected children and young adults, including 44 hospitalized 9 critically ill patients, with a comparison patient characteristics between nonhospitalized cohorts, as well noncritically cohorts. Children <1 year adolescents adults >15 years age were over-represented among patients (P = .07). Adolescents cohort .02).
Postdischarge treatment of acute osteomyelitis in children requires weeks antibiotic therapy, which can be administered orally or intravenously via a peripherally inserted central catheter (PICC). The catheters carry risk for serious complications, but limited evidence exists on the effectiveness oral therapy.To compare and adverse outcomes postdischarge therapy PICC route.We performed retrospective cohort study comparing osteomyelitis. Among hospitalized from January 1, 2009, through...
ABSTRACT Recently, cholesterol was identified as a physiologically important nutrient for Mycobacterium tuberculosis survival in chronically infected mice. However, it remained unclear precisely when is available to the bacterium and what additional bacterial functions are required its metabolism. Here, we show that igr locus, which previously found be essential intracellular growth virulence of M . , While -deficient strains grow identically wild type presence short- long-chain fatty acids,...
We demonstrate that the purified Staphylococcus aureus extracellular proteases aureolysin, ScpA, SspA, and SspB limit biofilm formation, with aureolysin having greatest impact. Using protease-deficient derivatives of LAC, we confirmed this is due to individual themselves. Purified a lesser extent ScpA SspB, also promoted dispersal an established biofilm. Mutation genes encoding these only partially restored formation in FPR3757 sarA mutant had little impact on restoring virulence murine...
Abstract Background Children and young adults were initially reported as largely spared from severe complications of SARS-CoV-2 infection, but the impact to this population has been significant. Methods This observational retrospective cohort study includes 420 symptomatic children with lab confirmed infection treated between March 15 June 16, 2020 at Children’s National Hospital in Washington DC. We identified compared cohorts non-hospitalized (N=324) hospitalized (N=96) patients, including...
Mycobacterium tuberculosis lives intracellularly, and many facets of its interactions with host cells are not well understood. We screened an M. transposon library for mutants exhibiting reduced ability to kill eukaryotic cells. Four the identified had insertions in 3 adjacent genes: single each 2 acyl-coenzyme A dehydrogenases (fadE) plus unique a cytochrome P450 homolog. mutant which these genes were replaced by allelic exchange was powerfully attenuated our macrophage viability assay,...
Central line-associated bloodstream infections (CLABSIs) and surgical site (SSIs) are major healthcare-associated that can be prevented by consistently applying evidence-based infection prevention practices. To assess equity in preventing CLABSIs SSIs pediatric patients at a free-standing hospital, where practices implemented. This observational study evaluated 2 cohorts of under 18 years. The CLABSI cohort included inpatients with central line between 1/1/2016 12/31/2022, the SSI undergoing...
Abstract Background Human parechovirus (PeVA) typically causes self-limiting respiratory and gastrointestinal infections. However, in infants, it can cause severe sepsis-like illness CNS disease. In 2022, a CDC Health Advisory reported PeVA infections young infants multiple states. Our aim was to describe the clinical features, laboratory characteristics, outcomes with infection during 2022 multistate outbreak. Methods A multicenter retrospective chart review conducted at 7 children’s...
Background Despite the high burden of rheumatic heart disease in sub-Saharan Africa, diagnosis with acute fever (ARF) is exceedingly rare. Here, we report results first prospective epidemiologic survey to diagnose and characterize ARF at community level Africa. Methods Results A cross-sectional study was conducted Lira, Uganda, inform design a broader survey. Key messages were distributed community, children aged 3 17 years included if they had either (1) joint pain, (2) suspicion carditis,...
Objective Despite substantial variation of streptococcal antibody titres among global populations, there is no data on normal values in sub-Saharan Africa. The objective this study was to establish for antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies Uganda. Design This an observational cross-sectional study. Setting conducted at Mulago National Referral Hospital, which located the capital city, Kampala, includes Uganda Heart Institute. Patients Participants (aged 0–50...
Urinary tract infections (UTIs) are a common diagnosis within the pediatric emergency department (ED). Because of necessary delay in obtaining urine culture results, clinicians must decide whether to prescribe antibiotics for suspected UTI before results. The primary objective this study was identify proportion children given empiric who subsequently did not meet consensus definition an UTI. secondary factors associated with return visits ED after index visit We also attempted predictors...
Secondary skin infection with Staphylococcus aureus is a significant problem in atopic dermatitis (AD) patients.This study evaluated antimicrobial resistance patterns of S isolates from lesions AD patients and empiric prescribing patterns.Resistance positive cultures obtained the Allergy/Immunology clinic May 1, 2006, to December 31, 2008, were compared all outpatient wound over same period.Fifty-nine 38 patients. was most common pathogen cultured (53/59 cultures). clindamycin methicillin...