Sarah Mackie
A5107303443- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Systemic Sclerosis and Related Diseases
- Urticaria and Related Conditions
- Atherosclerosis and Cardiovascular Diseases
- Autoimmune and Inflammatory Disorders Research
- Glaucoma and retinal disorders
- Renal Diseases and Glomerulopathies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Retinal Diseases and Treatments
- Delphi Technique in Research
- Adrenal Hormones and Disorders
- Retinal Imaging and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Cell Adhesion Molecules Research
- Autoimmune Bullous Skin Diseases
- Retinal and Optic Conditions
- Acute Kidney Injury Research
- Osteoarthritis Treatment and Mechanisms
- Clinical practice guidelines implementation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Corneal surgery and disorders
NIHR Leeds Musculoskeletal Biomedical Research Unit
2016-2025
University of Leeds
2016-2025
Leeds Teaching Hospitals NHS Trust
2015-2025
King's College London
2024-2025
Blood Cancer UK
2025
Chapel Allerton Hospital
2011-2024
Jena University Hospital
2024
Medizinische Hochschule Hannover
2024
HNO Bad Bramstedt
2024
National Institute for Health Research
2013-2024
Abstract Recent evidence suggests a role for natural killer (NK) cells in the control of multiple myeloma. We show that expression NK cell receptor DNAM-1 (CD226) is reduced on CD56dim from myeloma patients with active disease compared remission and healthy controls. This suggested this might play NK-myeloma interactions. The ligands Nectin-2 (CD112) poliovirus (PVR; CD155) were expressed by most patient samples analyzed. killing patient-derived myelomas expressing PVR and/or was dependent,...
Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis eye diseases systemic disorders 1 . However, development AI models requires substantial annotation are usually task-specific with limited generalizability to different clinical applications 2 Here, we present RETFound, a foundation model that learns generalizable representations from unlabelled provides basis label-efficient adaptation...
Abstract Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) management PMR. We used Grading Recommendations, Assessment, Development and Evaluation (GRADE) methodology a framework project. Accordingly, direction strength based on quality evidence, balance between desirable...
Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) management PMR. We used Grading Recommendations, Assessment, Development and Evaluation (GRADE) methodology a framework project. Accordingly, direction strength based on quality evidence, balance between desirable undesirable...
Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical replacement and the treatment of choice for patients at high operative risk. The role TAVI in lower risk unclear.To determine whether noninferior surgery moderately increased risk.In this randomized clinical trial conducted 34 UK centers, 913 aged 70 years or older with severe, symptomatic stenosis due age comorbidity were enrolled between April 2014 2018 followed up through 2019.TAVI using any CE mark...
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), prevalent PD subsequently assessed association these markers development a prospective research cohort.
We conducted a large-scale genetic analysis on giant cell arteritis (GCA), polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control from six different countries of European ancestry, was genotyped by the Immunochip array. also imputed HLA data previously validated imputation method to perform more comprehensive this genomic region. The strongest association signals were observed in region, rs477515 representing highest...
Abstract Background Acute kidney injury (AKI) is common among patients hospitalised with COVID-19 and associated worse prognosis. The aim of this study was to investigate the epidemiology, risk factors outcomes AKI in a large UK tertiary centre. Methods We analysed data consecutive adults admitted laboratory-confirmed diagnosis across two sites hospital London, UK, from 1st January 13th May 2020. Results Of 1248 inpatients included, 487 (39%) experienced (51% stage 1, 13% 2, 36% 3). weekly...
To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity giant cell arteritis (GCA) and evaluate its metric properties.The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise conducted using images bilateral common temporal arteries, parietal frontal branches as well axillary arteries from 16 patients with...
Objectives To determine whether whole-body MRI defines clinically relevant subgroups within polymyalgia rheumatica (PMR) including glucocorticoid responsiveness. Methods 22 patients with PMR and 16 rheumatoid arthritis (RA), untreated diagnosed by consultant rheumatologists, underwent whole-body, multiple-joint MRI, scored two experts. Patients reported they felt ‘back to normal’ on therapy were followed for a median of 2 years. Results All deemed respond glucocorticoids clinically. A...
The extent of inflammatory infiltrates in arteries from patients with giant-cell arteritis (GCA) have been described using different terms and definitions. Studies investigating the relationship between GCA histological features clinical manifestations produced controversial results. aims this study were to characterize validate patterns temporal artery biopsies (TABs) patients, explore additional features, including coexistence patterns, also investigate laboratory features. We performed...